Harmonizome 3.0

AXL receptor tyrosine kinase

The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. The encoded protein acts as a host cell receptor for multiple viruses, including Marburg, Ebola and Lassa viruses and is a candidate receptor for the SARS-CoV2 virus. [provided by RefSeq, Sep 2021]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term axl in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From KEA Substrates of Kinases

substrates of the kinase AXL from the curated KEA Substrates of Kinases dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for AXL from the Pathway Commons Protein-Protein Interactions dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the AXL gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From Kinase Library Tyrosine Kinome Atlas

substrates of the kinase AXL from the Kinase Library Tyrosine Kinome Atlas dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the AXL gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From CellMarker Gene-Cell Type Associations

genes associated with the Axl+ CD123+ Plasmacytoid dendritic cell (CD123+ Axl+DC)_Blood_Human cell type from the CellMarker Gene-Cell Type Associations dataset.

From CellMarker Gene-Cell Type Associations

genes associated with the Axl+ CD11c+ Plasmacytoid dendritic cell (CD11c+ Axl+DC)_Blood_Human cell type from the CellMarker Gene-Cell Type Associations dataset.

From CORUM Protein Complexes

proteins in the AXL homodimer complex protein complex from the CORUM Protein Complexes dataset.

From NURSA Protein Complexes

proteins in the BL1152 (AXL) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From HuBMAP Azimuth Cell Type Annotations

genes associated with the Human - PBMC - L2 - AXL+ Dendritic Cell cell type from the HuBMAP Azimuth Cell Type Annotations dataset.

From HuBMAP Azimuth Cell Type Annotations

genes associated with the Human - PBMC - L3 - AXL+ myeloid dendritic cell cell type from the HuBMAP Azimuth Cell Type Annotations dataset.

From HuBMAP Azimuth Cell Type Annotations

genes associated with the Human - PBMC - L3 - AXL+ plasmacytoid dendritic cell cell type from the HuBMAP Azimuth Cell Type Annotations dataset.

From HuBMAP Azimuth Cell Type Annotations

genes associated with the Human - Bone Marrow - L2 - AXL+ Dendritic Cell cell type from the HuBMAP Azimuth Cell Type Annotations dataset.

From CellMarker Gene-Cell Type Associations

genes associated with the AXL+SIGLEC6+ dendritic cell_Blood_Human cell type from the CellMarker Gene-Cell Type Associations dataset.

From CellMarker Gene-Cell Type Associations

genes associated with the AXL+ SIGLEC6+ dendritic cell_Undefined_Human cell type from the CellMarker Gene-Cell Type Associations dataset.