Harmonizome 3.0

spleen tyrosine kinase

This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

From NURSA Protein Complexes

proteins in the BL2371 (SYK) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the PLC-gamma-2-Syk-LAT-FcR-gamma complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the LAT-GRB2 complex, Fyn-mLck(KA) or Syk kinase activated protein complex from the CORUM Protein Complexes dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term syk in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Hub Proteins Protein-Protein Interactions

interacting proteins for hub protein SYK from the curated Hub Proteins Protein-Protein Interactions dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Tyrosine-protein kinase SYK/ZAP-70, inter-SH2 domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Tyrosine-protein kinase, non-receptor SYK/ZAP-70 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From KEA Substrates of Kinases

substrates of the kinase SYK from the curated KEA Substrates of Kinases dataset.

From NURSA Protein Complexes

proteins in the SC-10771 (SYK) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From NURSA Protein Complexes

proteins in the BL2370 (SYK) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for SYK from the Pathway Commons Protein-Protein Interactions dataset.

From Phosphosite Textmining Biological Term Annotations

proteins co-occuring with the biological term syk in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.

From PhosphoSitePlus Substrates of Kinases

substrates of the kinase SYK from the curated PhosphoSitePlus Substrates of Kinases dataset.

From Kinase Library Tyrosine Kinome Atlas

substrates of the kinase SYK from the Kinase Library Tyrosine Kinome Atlas dataset.

From DGIdb Drug Targets 2026

interacting proteins for the SYK INHIBITOR III drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the SYK INHIBITOR drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the SYK INHIBITOR II drug from theDGIdb Drug Targets 2026 dataset.