Harmonizome 3.0

histone deacetylase 1

Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. [provided by RefSeq, Jul 2008]

From NURSA Protein Complexes

proteins in the BL2607 (HDAC1) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the E2f5-Rbl2-Hdac1 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the SKI-NCOR1-SIN3A-HDAC1 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the HDAC1-associated core complex cI protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the pRb2/p130-multimolecular complex (RB2, E2F4, HDAC1, SUV39H1, P300) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the SMAD3-cSKI-SIN3A-HDAC1 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the HDAC1-associated core complex cII protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the pRb2/p130-multimolecular complex (DNMT1, E2F5, SuV39H1, HDAC1, RBL2) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the TIP5-DNMT-HDAC1 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the HDAC1-associated protein complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the p33ING1b-HDAC1 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the NCOR-SIN3-HDAC1 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the RB1-HDAC1-BRG1 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Rb-HDAC1 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the mSin3A-HDAC1-HDAC2 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Tis7-Sin3-Hdac1-Ncor1-Sap30 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the pRb2/p130-multimolecular complex (DNMT1, E2F4, SuV39H1, HDAC1, RBL2) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Sin3-Hdac1-Sds3 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the BRCA1-HDAC1-HDAC2 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the CBF1-HDAC1-SMRT complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Hdac1-Mecp2-Rcor1-Sin3a complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the DNMT1-RB1-HDAC1-E2F1 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the NK-3-Groucho-HIPK2-SIN3A-RbpA48-HDAC1 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the FE65-TSHZ3-HDAC1 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the pRb2/p130-multimolecular complex (RB2, E2F5, HDAC1, SUV39H1, P300) protein complex from the CORUM Protein Complexes dataset.

From ENCODE Transcription Factor Targets

target genes of the HDAC1 transcription factor in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term hdac1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Hub Proteins Protein-Protein Interactions

interacting proteins for hub protein HDAC1 from the curated Hub Proteins Protein-Protein Interactions dataset.

From MSigDB Cancer Gene Co-expression Modules

co-expressed genes for HDAC1 from the MSigDB Cancer Gene Co-expression Modules dataset.

From NURSA Protein Complexes

proteins in the SC-8410 (HDAC1) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From NURSA Protein Complexes

proteins in the BL2608 (HDAC1) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for HDAC1 from the Pathway Commons Protein-Protein Interactions dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the HDAC1 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From Reactome Pathways 2024

proteins participating in the Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 pathway from the Reactome Pathways 2024 dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the HDAC1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.