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CDC6 Genecell division cycle 6 The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins. [provided by RefSeq, Jul 2008] |
cdc6 Gene SetFrom GeneRIF Biological Term Annotations genes co-occuring with the biological term cdc6 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. |
CDC6 Gene SetFrom Pathway Commons Protein-Protein Interactions interacting proteins for CDC6 from the Pathway Commons Protein-Protein Interactions dataset. |
CDC6 Gene SetFrom LINCS L1000 CMAP CRISPR Knockout Consensus Signatures genes differentially expressed following the CDC6 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset. |
CDC6 Gene SetFrom CM4AI KOLF21J CRISPRi Gene Perturbation Atlas genes differentially expressed following the CDC6 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas. |
MCM8-ORC2-CDC6 complex Gene Setproteins in the MCM8-ORC2-CDC6 complex protein complex from the CORUM Protein Complexes dataset. |
CDC6, C-terminal domain Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the CDC6, C-terminal domain protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
Cell division protein Cdc6/18 Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the Cell division protein Cdc6/18 protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
BL9062 (CDC6) Gene Setproteins in the BL9062 (CDC6) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset. |
CDC6 association with the ORC:origin complex Gene Setproteins participating in the CDC6 association with the ORC:origin complex pathway from the Reactome Pathways dataset. |
CDT1 association with the CDC6:ORC:origin complex Gene Setproteins participating in the CDT1 association with the CDC6:ORC:origin complex pathway from the Reactome Pathways dataset. |
CDK-mediated phosphorylation and removal of Cdc6 Gene Setproteins participating in the CDK-mediated phosphorylation and removal of Cdc6 pathway from the Reactome Pathways dataset. |
CDC6 association with the ORC:origin complex Gene Setproteins participating in the CDC6 association with the ORC:origin complex pathway from the Reactome Pathways 2024 dataset. |
CDK-mediated phosphorylation and removal of Cdc6 Gene Setproteins participating in the CDK-mediated phosphorylation and removal of Cdc6 pathway from the Reactome Pathways 2024 dataset. |