Harmonizome 3.0

lipopolysaccharide binding protein

The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that the encoded protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). [provided by RefSeq, Apr 2012]

upstream binding protein 1 (LBP-1a)

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of viral transcription and positive regulation of transcription by RNA polymerase II. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Mar 2025]

transcription factor CP2-like

transcription factor CP2-like 1

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in regulation of transcription by RNA polymerase II. Predicted to be located in chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Mar 2025]

transcription factor CP2

This gene encodes a transcription factor that binds the alpha-globin promoter and activates transcription of the alpha-globin gene. The encoded protein regulates erythroid gene expression, plays a role in the transcriptional switch of globin gene promoters, and it activates many other cellular and viral gene promoters. The gene product interacts with certain inflammatory response factors, and polymorphisms of this gene may be involved in the pathogenesis of Alzheimer's disease. [provided by RefSeq, Mar 2010]

From MotifMap Predicted Transcription Factor Targets

target genes of the CP2/LBP-1c/LSF transcription factor predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cp2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term lbp in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From GO Molecular Function Annotations 2015

genes performing the cp2 mannose-ethanolamine phosphotransferase activity molecular function from the curated GO Molecular Function Annotations 2015 dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the CP2 transcription factor protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From MotifMap Predicted Transcription Factor Targets

target genes of the LBP-1 transcription factor predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for LBP from the Pathway Commons Protein-Protein Interactions dataset.

From Reactome Pathways 2014

proteins participating in the Transfer of LPS from LBP carrier to CD14 pathway from the Reactome Pathways dataset.

From GO Molecular Function Annotations 2023

genes performing the CP2 mannose-ethanolamine phosphotransferase activity molecular function from the curated GO Molecular Function Annotations 2023 dataset.

From Reactome Pathways 2024

proteins participating in the Transfer of LPS from LBP carrier to CD14 pathway from the Reactome Pathways 2024 dataset.

From GO Molecular Function Annotations 2025

genes performing the CP2 mannose-ethanolamine phosphotransferase activity molecular function from the curated GO Molecular Function Annotations 2025 dataset.