Harmonizome 3.0

DDR1 antisense RNA 1 (head to head)

discoidin domain receptor tyrosine kinase 1

Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]

From LINCS L1000 CMAP Chemical Perturbation Consensus Signatures

genes differentially expressed following the DDR1-IN-1 small molecule perturbation from the LINCS L1000 CMAP Chemical Perturbation Consensus Signatures dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ddr1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From KEA Substrates of Kinases

substrates of the kinase DDR1 from the curated KEA Substrates of Kinases dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for DDR1 from the Pathway Commons Protein-Protein Interactions dataset.

From Kinase Library Tyrosine Kinome Atlas

substrates of the kinase DDR1 from the Kinase Library Tyrosine Kinome Atlas dataset.

From DGIdb Drug Targets 2026

interacting proteins for the DDR1/2 INHIBITOR 5N drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the DDR1 INHIBITOR 7RH drug from theDGIdb Drug Targets 2026 dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the DDR1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.