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FGFR1 Genefibroblast growth factor receptor 1 The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008] |
fgfr1 Gene SetFrom GeneRIF Biological Term Annotations genes co-occuring with the biological term fgfr1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. |
FGFR1 Gene SetFrom KEA Substrates of Kinases substrates of the kinase FGFR1 from the curated KEA Substrates of Kinases dataset. |
FGFR1 Gene SetFrom Pathway Commons Protein-Protein Interactions interacting proteins for FGFR1 from the Pathway Commons Protein-Protein Interactions dataset. |
FGFR1 Gene SetFrom PhosphoSitePlus Substrates of Kinases substrates of the kinase FGFR1 from the curated PhosphoSitePlus Substrates of Kinases dataset. |
FGFR1 Gene SetFrom LINCS L1000 CMAP CRISPR Knockout Consensus Signatures genes differentially expressed following the FGFR1 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset. |
FGFR1 Gene SetFrom Kinase Library Tyrosine Kinome Atlas substrates of the kinase FGFR1 from the Kinase Library Tyrosine Kinome Atlas dataset. |
FGFR1 Gene SetFrom CM4AI KOLF21J CRISPRi Gene Perturbation Atlas genes differentially expressed following the FGFR1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas. |
FGFR1 oncogene partner (FOP), N-terminal dimerisation domain Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the FGFR1 oncogene partner (FOP), N-terminal dimerisation domain protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
Signaling by FGFR1 mutants Gene Setproteins participating in the Signaling by FGFR1 mutants pathway from the Reactome Pathways dataset. |
Signaling by FGFR1 fusion mutants Gene Setproteins participating in the Signaling by FGFR1 fusion mutants pathway from the Reactome Pathways dataset. |
Signaling by FGFR1 amplification mutants Gene Setproteins participating in the Signaling by FGFR1 amplification mutants pathway from the Reactome Pathways dataset. |
FGFR1 ligand binding and activation Gene Setproteins participating in the FGFR1 ligand binding and activation pathway from the Reactome Pathways dataset. |
Signaling by activated point mutants of FGFR1 Gene Setproteins participating in the Signaling by activated point mutants of FGFR1 pathway from the Reactome Pathways dataset. |
Downstream signaling of activated FGFR1 Gene Setproteins participating in the Downstream signaling of activated FGFR1 pathway from the Reactome Pathways 2024 dataset. |
FGFR1 ligand binding and activation Gene Setproteins participating in the FGFR1 ligand binding and activation pathway from the Reactome Pathways 2024 dataset. |
FGFR1 mutant receptor activation Gene Setproteins participating in the FGFR1 mutant receptor activation pathway from the Reactome Pathways 2024 dataset. |
FGFRL1 modulation of FGFR1 signaling Gene Setproteins participating in the FGFRL1 modulation of FGFR1 signaling pathway from the Reactome Pathways 2024 dataset. |
FRS-mediated FGFR1 signaling Gene Setproteins participating in the FRS-mediated FGFR1 signaling pathway from the Reactome Pathways 2024 dataset. |
Negative regulation of FGFR1 signaling Gene Setproteins participating in the Negative regulation of FGFR1 signaling pathway from the Reactome Pathways 2024 dataset. |
PI-3K cascade:FGFR1 Gene Setproteins participating in the PI-3K cascade:FGFR1 pathway from the Reactome Pathways 2024 dataset. |
Phospholipase C-mediated cascade: FGFR1 Gene Setproteins participating in the Phospholipase C-mediated cascade: FGFR1 pathway from the Reactome Pathways 2024 dataset. |
SHC-mediated cascade:FGFR1 Gene Setproteins participating in the SHC-mediated cascade:FGFR1 pathway from the Reactome Pathways 2024 dataset. |
Signaling by FGFR1 Gene Setproteins participating in the Signaling by FGFR1 pathway from the Reactome Pathways 2024 dataset. |
Signaling by FGFR1 amplification mutants Gene Setproteins participating in the Signaling by FGFR1 amplification mutants pathway from the Reactome Pathways 2024 dataset. |
Signaling by FGFR1 in disease Gene Setproteins participating in the Signaling by FGFR1 in disease pathway from the Reactome Pathways 2024 dataset. |
Signaling by activated point mutants of FGFR1 Gene Setproteins participating in the Signaling by activated point mutants of FGFR1 pathway from the Reactome Pathways 2024 dataset. |
Signaling by cytosolic FGFR1 fusion mutants Gene Setproteins participating in the Signaling by cytosolic FGFR1 fusion mutants pathway from the Reactome Pathways 2024 dataset. |
Signaling by plasma membrane FGFR1 fusions Gene Setproteins participating in the Signaling by plasma membrane FGFR1 fusions pathway from the Reactome Pathways 2024 dataset. |
Myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB, and FGFR1 Gene SetFrom DISEASES Curated Gene-Disease Association Evidence Scores 2025 genes involed in the disease Myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB, and FGFR1 from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset. |
Myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB, and FGFR1 Gene SetFrom DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 genes co-occuring with the disease Myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB, and FGFR1 in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. |
Myeloid and lymphoid neoplasms associated with FGFR1 abnormalities Gene SetFrom DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 genes co-occuring with the disease Myeloid and lymphoid neoplasms associated with FGFR1 abnormalities in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. |
