| Name |
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FGFR4 Genefibroblast growth factor receptor 4 The protein encoded by this gene is a tyrosine kinase and cell surface receptor for fibroblast growth factors. The encoded protein is involved in the regulation of several pathways, including cell proliferation, cell differentiation, cell migration, lipid metabolism, bile acid biosynthesis, vitamin D metabolism, glucose uptake, and phosphate homeostasis. This protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment, and a cytoplasmic tyrosine kinase domain. The extracellular portion interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. [provided by RefSeq, Aug 2017] |
fgfr4 Gene SetFrom GeneRIF Biological Term Annotations genes co-occuring with the biological term fgfr4 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. |
FGFR4 Gene SetFrom KEA Substrates of Kinases substrates of the kinase FGFR4 from the curated KEA Substrates of Kinases dataset. |
FGFR4 Gene SetFrom Pathway Commons Protein-Protein Interactions interacting proteins for FGFR4 from the Pathway Commons Protein-Protein Interactions dataset. |
FGFR4 Gene SetFrom PhosphoSitePlus Substrates of Kinases substrates of the kinase FGFR4 from the curated PhosphoSitePlus Substrates of Kinases dataset. |
FGFR4 Gene SetFrom Kinase Library Tyrosine Kinome Atlas substrates of the kinase FGFR4 from the Kinase Library Tyrosine Kinome Atlas dataset. |
FGFR4 Gene SetFrom CM4AI KOLF21J CRISPRi Gene Perturbation Atlas genes differentially expressed following the FGFR4 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas. |
Signaling by FGFR4 mutants Gene Setproteins participating in the Signaling by FGFR4 mutants pathway from the Reactome Pathways dataset. |
FGFR4 ligand binding and activation Gene Setproteins participating in the FGFR4 ligand binding and activation pathway from the Reactome Pathways dataset. |
FGFR4 p G388R signaling Gene SetFrom WikiPathways Pathways 2024 proteins participating in the FGFR4 p G388R signaling pathway from the WikiPathways Pathways 2024 dataset. |
Downstream signaling of activated FGFR4 Gene Setproteins participating in the Downstream signaling of activated FGFR4 pathway from the Reactome Pathways 2024 dataset. |
FGFR4 ligand binding and activation Gene Setproteins participating in the FGFR4 ligand binding and activation pathway from the Reactome Pathways 2024 dataset. |
FGFR4 mutant receptor activation Gene Setproteins participating in the FGFR4 mutant receptor activation pathway from the Reactome Pathways 2024 dataset. |
FRS-mediated FGFR4 signaling Gene Setproteins participating in the FRS-mediated FGFR4 signaling pathway from the Reactome Pathways 2024 dataset. |
Negative regulation of FGFR4 signaling Gene Setproteins participating in the Negative regulation of FGFR4 signaling pathway from the Reactome Pathways 2024 dataset. |
PI-3K cascade:FGFR4 Gene Setproteins participating in the PI-3K cascade:FGFR4 pathway from the Reactome Pathways 2024 dataset. |
Phospholipase C-mediated cascade; FGFR4 Gene Setproteins participating in the Phospholipase C-mediated cascade; FGFR4 pathway from the Reactome Pathways 2024 dataset. |
SHC-mediated cascade:FGFR4 Gene Setproteins participating in the SHC-mediated cascade:FGFR4 pathway from the Reactome Pathways 2024 dataset. |
Signaling by FGFR4 Gene Setproteins participating in the Signaling by FGFR4 pathway from the Reactome Pathways 2024 dataset. |
Signaling by FGFR4 in disease Gene Setproteins participating in the Signaling by FGFR4 in disease pathway from the Reactome Pathways 2024 dataset. |
FGFR4 INHIBITOR H3B-6527 Gene Setinteracting proteins for the FGFR4 INHIBITOR H3B-6527 drug from theDGIdb Drug Targets 2026 dataset. |
FGFR4 ANTAGONIST INCB062079 Gene Setinteracting proteins for the FGFR4 ANTAGONIST INCB062079 drug from theDGIdb Drug Targets 2026 dataset. |
