Harmonizome 3.0

hepatic leukemia factor

This gene encodes a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription factors. The encoded protein forms homodimers or heterodimers with other PAR family members and binds sequence-specific promoter elements to activate transcription. Chromosomal translocations fusing portions of this gene with the E2A gene cause a subset of childhood B-lineage acute lymphoid leukemias. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

From Achilles Cell Line Gene Essentiality Profiles

gene knockdowns changing fitness of HLF relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.

From CCLE Cell Line Gene CNV Profiles

genes with high or low copy number in HLF relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.

From CCLE Cell Line Gene Expression Profiles

genes with high or low expression in HLF relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.

From CCLE Cell Line Gene Mutation Profiles

genes mutated in the HLF cell line from the CCLE Cell Line Gene Mutation Profiles dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term hlf in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From JASPAR Predicted Transcription Factor Targets

target genes of the HLF transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for HLF from the Pathway Commons Protein-Protein Interactions dataset.

From DepMap CRISPR Gene Dependency

gene knockdowns changing fitness of HLF relative to other cell lines from the DepMap CRISPR Gene Dependency Dataset.

From JASPAR Predicted Human Transcription Factor Targets 2025

target genes of the HLF transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the HLF gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From CORUM Protein Complexes

proteins in the ARNT-HLF complex protein complex from the CORUM Protein Complexes dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC6488738-mmc6.xlsx-HLF-Target_Gene_HLF transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.