Name

IRF5 Gene

interferon regulatory factor 5

This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Alternative promoter use and alternative splicing result in multiple transcript variants, and a 30-nt indel polymorphism (SNP rs60344245) can result in loss of a 10-aa segment. [provided by RefSeq, Dec 2016]

irf5 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term irf5 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

IRF5 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for IRF5 from the Pathway Commons Protein-Protein Interactions dataset.

IRF5 Gene Set

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the IRF5 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

IRF5 Gene Set

From JASPAR Predicted Human Transcription Factor Targets 2025

target genes of the IRF5 transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.

IRF5 Gene Set

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the IRF5 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

SLC15A4:TASL-dependent IRF5 activation Gene Set

From Reactome Pathways 2024

proteins participating in the SLC15A4:TASL-dependent IRF5 activation pathway from the Reactome Pathways 2024 dataset.