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IRF5 Geneinterferon regulatory factor 5 This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Alternative promoter use and alternative splicing result in multiple transcript variants, and a 30-nt indel polymorphism (SNP rs60344245) can result in loss of a 10-aa segment. [provided by RefSeq, Dec 2016] |
irf5 Gene SetFrom GeneRIF Biological Term Annotations genes co-occuring with the biological term irf5 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. |
IRF5 Gene SetFrom Pathway Commons Protein-Protein Interactions interacting proteins for IRF5 from the Pathway Commons Protein-Protein Interactions dataset. |
IRF5 Gene SetFrom LINCS L1000 CMAP CRISPR Knockout Consensus Signatures genes differentially expressed following the IRF5 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset. |
IRF5 Gene SetFrom JASPAR Predicted Human Transcription Factor Targets 2025 target genes of the IRF5 transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. |
IRF5 Gene SetFrom CM4AI KOLF21J CRISPRi Gene Perturbation Atlas genes differentially expressed following the IRF5 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas. |
SLC15A4:TASL-dependent IRF5 activation Gene Setproteins participating in the SLC15A4:TASL-dependent IRF5 activation pathway from the Reactome Pathways 2024 dataset. |