Harmonizome 3.0

mutS homolog 2

This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

From NURSA Protein Complexes

proteins in the JQ006 (MSH2) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the PCNA-MSH2-MSH6 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the ERCC1-ERCC4-MSH2 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the MSH2-MSH6-PMS2-MLH1 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the MSH2-MSH6-PMS1-MLH1 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the MSH2-MSH6 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the MSH2-MSH3 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the MSH2-MLH1-PMS2 DNA-repair initiation complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the MSH2/6-BLM-p53-RAD51 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the MSH2-MLH1-PMS2-PCNA DNA-repair initiation complex protein complex from the CORUM Protein Complexes dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term msh2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From MSigDB Cancer Gene Co-expression Modules

co-expressed genes for MSH2 from the MSigDB Cancer Gene Co-expression Modules dataset.

From NURSA Protein Complexes

proteins in the BL2094 (MSH2) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From NURSA Protein Complexes

proteins in the BL323 (MSH2) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for MSH2 from the Pathway Commons Protein-Protein Interactions dataset.

From Reactome Pathways 2014

proteins participating in the Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) pathway from the Reactome Pathways dataset.

From Reactome Pathways 2024

proteins participating in the Defective Mismatch Repair Associated With MSH2 pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) pathway from the Reactome Pathways 2024 dataset.

From ClinVar Gene-Phenotype Associations 2025

genes associated with the MSH2 POLYMORPH phenotype from the curated ClinVar Gene-Phenotype Associations 2025 dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the MSH2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.