Harmonizome 3.0

LEF1 antisense RNA 1

lymphoid enhancer-binding factor 1

This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

From MotifMap Predicted Transcription Factor Targets

target genes of the LEF1, TCF1 transcription factor predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term tcf1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From CORUM Protein Complexes

proteins in the Lef1-Tle1 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Pax3-Lef1-Tle4 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Lef1-Tle1-Ctnnb1 complex protein complex from the CORUM Protein Complexes dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term lef1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for LEF1 from the Pathway Commons Protein-Protein Interactions dataset.

From ChEA Transcription Factor Targets 2022

target genes of the LEF1-29337183-MESC-MOUSE-STEM transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the LEF1 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations

genes differentially expressed following the Perturb_4982_KO_Tcf7/Lef1/Tcf7l1/Tcf7l2_ERP129796 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

From PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations

genes differentially expressed following the Perturb_4984_KO_Tcf7/Lef1/Tcf7l1/Tcf7l2_ERP129796 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

From JASPAR Predicted Mouse Transcription Factor Targets 2025

target genes of the Lef1 transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2925 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC5013636-ncomms12601-s5.xlsx-LEF1-Groups_LEF1 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC11239940-44319_2024_164_MOESM1_ESM.pdf-22-LEF1-AS1_LEF1 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the LEF1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.