Harmonizome 3.0

mitogen-activated protein kinase kinase kinase 14

This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. [provided by RefSeq, Jul 2008]

MAP3K14 antisense RNA 1

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term map3k14 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Hub Proteins Protein-Protein Interactions

interacting proteins for hub protein MAP3K14 from the curated Hub Proteins Protein-Protein Interactions dataset.

From KEA Substrates of Kinases

substrates of the kinase MAP3K14 from the curated KEA Substrates of Kinases dataset.

From MSigDB Cancer Gene Co-expression Modules

co-expressed genes for MAP3K14 from the MSigDB Cancer Gene Co-expression Modules dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for MAP3K14 from the Pathway Commons Protein-Protein Interactions dataset.

From PhosphoSitePlus Substrates of Kinases

substrates of the kinase MAP3K14 from the curated PhosphoSitePlus Substrates of Kinases dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the MAP3K14 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the MAP3K14 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From CORUM Protein Complexes

proteins in the CHUK-IKBKB-MAP3K14 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the TNF-alpha/NF-kappa B signaling complex (SEC16A, CHUK, IKBKB, NFKB2, REL, IKBKG, MAP3K14, RELA, FBXW7, USP2) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the IkappaB kinase complex (IKBKB, CHUK, IKBKAP, NFKBIA, RELA, MAP3K14) protein complex from the CORUM Protein Complexes dataset.