Name

HCRT Gene

hypocretin (orexin) neuropeptide precursor

This gene encodes a hypothalamic neuropeptide precursor protein that gives rise to two mature neuropeptides, orexin A and orexin B, by proteolytic processing. Orexin A and orexin B, which bind to orphan G-protein coupled receptors HCRTR1 and HCRTR2, function in the regulation of sleep and arousal. This neuropeptide arrangement may also play a role in feeding behavior, metabolism, and homeostasis. [provided by RefSeq, Jan 2010]

HCRTR2 Gene

hypocretin (orexin) receptor 2

The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein binds the hypothalamic neuropeptides orexin A and orexin B. A related gene (HCRTR1) encodes a G-protein coupled receptor that selectively binds orexin A. [provided by RefSeq, Jan 2009]

HCRTR1 Gene

hypocretin (orexin) receptor 1

The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein selectively binds the hypothalamic neuropeptide orexin A. A related gene (HCRTR2) encodes a G-protein coupled receptor that binds orexin A and orexin B. [provided by RefSeq, Jan 2009]

OREXIN-B Gene Set

From DGIdb Drug Targets 2026

interacting proteins for the OREXIN-B drug from theDGIdb Drug Targets 2026 dataset.

orexin Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term orexin in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

orexin receptor activity Gene Set

From GO Molecular Function Annotations 2015

genes performing the orexin receptor activity molecular function from the curated GO Molecular Function Annotations 2015 dataset.

[Ala11 D-Leu15]orexin-B Gene Set

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the [Ala11 D-Leu15]orexin-B ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

Orexin receptor family Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Orexin receptor family protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Orexin receptor 2 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Orexin receptor 2 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Orexin receptor 1 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Orexin receptor 1 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Prepro-orexin Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Prepro-orexin protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Orexin and neuropeptides FF and QRFP bind to their respective receptors Gene Set

From Reactome Pathways 2014

proteins participating in the Orexin and neuropeptides FF and QRFP bind to their respective receptors pathway from the Reactome Pathways dataset.

orexin receptor activity Gene Set

From GO Molecular Function Annotations 2023

genes performing the orexin receptor activity molecular function from the curated GO Molecular Function Annotations 2023 dataset.

type 2 orexin receptor binding Gene Set

From GO Molecular Function Annotations 2023

genes performing the type 2 orexin receptor binding molecular function from the curated GO Molecular Function Annotations 2023 dataset.

type 1 orexin receptor binding Gene Set

From GO Molecular Function Annotations 2023

genes performing the type 1 orexin receptor binding molecular function from the curated GO Molecular Function Annotations 2023 dataset.

orexin receptor binding Gene Set

From GO Molecular Function Annotations 2023

genes performing the orexin receptor binding molecular function from the curated GO Molecular Function Annotations 2023 dataset.

Orexin receptor pathway Gene Set

From WikiPathways Pathways 2024

proteins participating in the Orexin receptor pathway pathway from the WikiPathways Pathways 2024 dataset.

Orexin and neuropeptides FF and QRFP bind to their respective receptors Gene Set

From Reactome Pathways 2024

proteins participating in the Orexin and neuropeptides FF and QRFP bind to their respective receptors pathway from the Reactome Pathways 2024 dataset.

orexin receptor activity Gene Set

From GO Molecular Function Annotations 2025

genes performing the orexin receptor activity molecular function from the curated GO Molecular Function Annotations 2025 dataset.

type 2 orexin receptor binding Gene Set

From GO Molecular Function Annotations 2025

genes performing the type 2 orexin receptor binding molecular function from the curated GO Molecular Function Annotations 2025 dataset.

type 1 orexin receptor binding Gene Set

From GO Molecular Function Annotations 2025

genes performing the type 1 orexin receptor binding molecular function from the curated GO Molecular Function Annotations 2025 dataset.

orexin receptor binding Gene Set

From GO Molecular Function Annotations 2025

genes performing the orexin receptor binding molecular function from the curated GO Molecular Function Annotations 2025 dataset.

OREXIN-A Gene Set

From DGIdb Drug Targets 2026

interacting proteins for the OREXIN-A drug from theDGIdb Drug Targets 2026 dataset.

[125I]OREXIN A (HUMAN, MOUSE, RAT) Gene Set

From DGIdb Drug Targets 2026

interacting proteins for the [125I]OREXIN A (HUMAN, MOUSE, RAT) drug from theDGIdb Drug Targets 2026 dataset.

[ALA11, D-LEU15]OREXIN-B Gene Set

From DGIdb Drug Targets 2026

interacting proteins for the [ALA11, D-LEU15]OREXIN-B drug from theDGIdb Drug Targets 2026 dataset.