Harmonizome 3.0

phospholipid transfer protein

The protein encoded by this gene is one of at least two lipid transfer proteins found in human plasma. The encoded protein transfers phospholipids from triglyceride-rich lipoproteins to high density lipoprotein (HDL). In addition to regulating the size of HDL particles, this protein may be involved in cholesterol metabolism. At least two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

phospholipid scramblase family, member 5

Predicted to enable phospholipid scramblase activity. Predicted to be involved in plasma membrane phospholipid scrambling. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

phospholipid scramblase 2

This gene encodes a member of the phospholipid scramblase family. Phospholipid scramblases are membrane proteins that mediate calcium-dependent, non-specific movement of plasma membrane phospholipids and phosphatidylserine exposure. The encoded protein contains a low affinity calcium binding motif and may play a role in blood coagulation and apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

phospholipid scramblase 3

Enables calcium-dependent protein binding activity; metal ion binding activity; and phospholipid scramblase activity. Involved in several processes, including apoptotic process; cardiolipin biosynthetic process; and regulation of release of cytochrome c from mitochondria. Located in cytosol; mitochondrion; and plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

phospholipid scramblase 1

This gene encodes a phospholipid scramblase family member. The encoded protein is involved in disruption of the asymmetrical distribution of phospholipids between the inner and outer leaflets of the plasma membrane, resulting in externalization of phosphatidylserine. This cell membrane disruption plays an important role in the blood coagulation cascade as well as macrophage clearing of apoptotic cells. The encoded protein has additionally been implicated in gene regulation and interferon-induced antiviral responses. [provided by RefSeq, May 2022]

phospholipid scramblase-like

phospholipid scramblase 4

Enables CD4 receptor binding activity and enzyme binding activity. Predicted to be involved in plasma membrane phospholipid scrambling. Located in plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

phospholipid scramblase 4 pseudogene

phospholipid phosphatase 6

Enables isoprenoid diphosphate phosphatase activity and phosphatase activity. Involved in several processes, including phospholipid dephosphorylation; phospholipid metabolic process; and positive regulation of neutrophil activation. Located in endoplasmic reticulum membrane and nuclear membrane. [provided by Alliance of Genome Resources, Mar 2025]

phospholipid phosphatase 3

The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is a membrane glycoprotein localized at the cell plasma membrane. It has been shown to actively hydrolyze extracellular lysophosphatidic acid and short-chain phosphatidic acid. The expression of this gene is found to be enhanced by epidermal growth factor in Hela cells. [provided by RefSeq, Mar 2010]

phospholipid phosphatase 2

The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is similar to phosphatidic acid phosphatase type 2A (PPAP2A) and type 2B (PPAP2B). All three proteins contain 6 transmembrane regions, and a consensus N-glycosylation site. This protein has been shown to possess membrane associated PAP activity. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

phospholipid phosphatase 1

The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in synthesis of glycerolipids and in phospholipase D-mediated signal transduction. This enzyme is an integral membrane glycoprotein that plays a role in the hydrolysis and uptake of lipids from extracellular space. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]

phospholipid phosphatase related 1

This gene encodes a member of the plasticity-related gene (PRG) family. Members of the PRG family mediate lipid phosphate phosphatase activity in neurons and are known to be involved in neuronal plasticity. The protein encoded by this gene does not perform its function through enzymatic phospholipid degradation. This gene is strongly expressed in brain. It shows dynamic expression regulation during brain development and neuronal excitation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]

phospholipid phosphatase related 4

The protein encoded by this gene belongs to the lipid phosphate phosphatase (LPP) family. LPPs catalyze the dephosphorylation of a number of bioactive lipid mediators that regulate a variety of cell functions. This protein is specifically expressed in neurons. It is located in the membranes of outgrowing axons and has been shown to be important for axonal outgrowth during development and regenerative sprouting. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]

phospholipid phosphatase related 3

The proteins in the lipid phosphate phosphatase (LPP) family, including PRG2, are integral membrane proteins that modulate bioactive lipid phosphates including phosphatidate, lysophosphatidate, and sphingosine-1-phosphate in the context of cell migration, neurite retraction, and mitogenesis (Brauer et al., 2003 [PubMed 12730698]).[supplied by OMIM, Mar 2008]

phospholipid phosphatase 4

Enables diacylglycerol diphosphate phosphatase activity; identical protein binding activity; and phosphatidate phosphatase activity. Involved in phospholipid dephosphorylation and regulation of calcium ion import. Predicted to be located in plasma membrane. Predicted to be active in membrane. Biomarker of breast cancer. [provided by Alliance of Genome Resources, Mar 2025]

phospholipid phosphatase related 5

The protein encoded by this gene is a type 2 member of the phosphatidic acid phosphatase (PAP) family. All type 2 members of this protein family contain 6 transmembrane regions, and a consensus N-glycosylation site. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

tafazzin, phospholipid-lysophospholipid transacylase

This gene encodes a protein that is expressed at high levels in cardiac and skeletal muscle. Mutations in this gene have been associated with a number of clinical disorders including Barth syndrome, dilated cardiomyopathy (DCM), hypertrophic DCM, endocardial fibroelastosis, and left ventricular noncompaction (LVNC). Multiple transcript variants encoding different isoforms have been described. A long form and a short form of each of these isoforms is produced; the short form lacks a hydrophobic leader sequence and may exist as a cytoplasmic protein rather than being membrane-bound. Other alternatively spliced transcripts have been described but the full-length nature of all these transcripts is not known. [provided by RefSeq, Jul 2008]

phospholipid phosphatase 7 (inactive)

Predicted to enable sphingosine-1-phosphate phosphatase activity. Predicted to act upstream of or within negative regulation of myotube differentiation. Predicted to be located in endoplasmic reticulum membrane and nucleus. Predicted to be active in membrane and nuclear envelope. [provided by Alliance of Genome Resources, Mar 2025]

phospholipid phosphatase related 2

Predicted to enable phosphatidate phosphatase activity. Predicted to be involved in phospholipid dephosphorylation; phospholipid metabolic process; and signal transduction. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]

phospholipid phosphatase 5

Enables diacylglycerol diphosphate phosphatase activity and phosphatidate phosphatase activity. Involved in phospholipid dephosphorylation. Predicted to be located in cytoplasm and plasma membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transfer RNA lysine (anticodon CUU)

This record serves to anchor the annotations of this class of tRNAs at multiple locations on the human genome. The placements are predicted using tRNAscan-SE (Lowe, T.M. and Eddy, S.R. 1997. Nucleic Acids Res. 25:955-964, PubMed 9023104).

transfer RNA alanine (anticodon AGC)

This record serves to anchor the annotations of this class of tRNAs at multiple locations on the human genome. The placements are predicted using tRNAscan-SE (Lowe, T.M. and Eddy, S.R. 1997. Nucleic Acids Res. 25:955-964, PubMed 9023104).

transfer RNA-Leu (AAG) 4-1

transfer RNA-Arg (CCT) 5-1

transfer RNA-Gly (CCC) 1-1

transfer RNA-Trp (CCA) 5-1

transfer RNA-Gly (CCC) 2-2

transfer RNA-Pro (AGG) 1-1

transfer RNA-Ala (AGC) 9-1

transfer RNA-Ala (AGC) 9-2

transfer RNA-Lys (TTT) 17-1

nuclear-encoded mitochondrial transfer RNA-Ser (TGA) 3-1

transfer RNA-Gly (CCC) 5-1

transfer RNA-Trp (CCA) 4-1

transfer RNA-Lys (TTT) 6-1

transfer RNA-Cys (GCA) 2-4

transfer RNA-Ser (TGA) 3-1

transfer RNA-Cys (GCA) 2-1

transfer RNA-Cys (GCA) 2-2

transfer RNA-Cys (GCA) 2-3

transfer RNA-Asp (GTC) 6-1

transfer RNA-Gly (TCC) 2-6

transfer RNA-Gly (TCC) 2-5

transfer RNA-Gly (TCC) 2-3

transfer RNA-Gly (TCC) 2-2

transfer RNA-Gly (TCC) 2-1

phosphatidylinositol transfer protein, cytoplasmic 1

This gene encodes a member of the phosphatidylinositol transfer protein family. The encoded cytoplasmic protein plays a role in multiple processes including cell signaling and lipid metabolism by facilitating the transfer of phosphatidylinositol between membrane compartments. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 1. [provided by RefSeq, May 2012]

transfer RNA arginine (anticodon ACG)

This record serves to anchor the annotations of this class of tRNAs at multiple locations on the human genome. The placements are predicted using tRNAscan-SE (Lowe, T.M. and Eddy, S.R. 1997. Nucleic Acids Res. 25:955-964, PubMed 9023104).

transfer RNA-Cys (GCA) 9-4

transfer RNA-Asn (GTT) 8-1

transfer RNA-Leu (TAG) 1-1

transfer RNA-Asn (GTT) 17-1

nuclear-encoded mitochondrial transfer RNA-Leu (TAA) 1-1

transfer RNA-Gln (CTG) 8-2

transfer RNA-Thr (CGT) 2-1

transfer RNA-Lys (TTT) 2-1

transfer RNA-undetermined (NNN) 6-1

transfer RNA-Gln (CTG) 18-1

transfer RNA-Gly (TCC) 6-1

transfer RNA-Cys (GCA) 11-1

transfer RNA-Leu (AAG) 5-1

transfer RNA-Ala (TGC) 1-1

transfer RNA-Gln (CTG) 1-5

transfer RNA-Val (CAC) 4-1

transfer RNA-Ala (AGC) 8-1

transfer RNA-Ala (AGC) 8-2

transfer RNA-Phe (GAA) 5-1

transfer RNA-Gly (CCC) 1-2

transfer RNA-Ser (TGA) 2-1

Hong et al. (1987) [PubMed 3648680] sequenced a human serine (UGA) tRNA by the dideoxysequencing method. The gene forms a typical cloverleaf structure with all appropriate conserved bases. It shows high nucleotide sequence homology with a previously sequenced serine tRNA (Yoo, 1984).[supplied by OMIM, Sep 2009]

transfer RNA-Asn (GTT) 14-1

transfer RNA-Ala (AGC) 21-1

transfer RNA-Lys (TTT) 7-1

transfer RNA-Arg (CCG) 1-1

transfer RNA-Ala (TGC) 10-1

transfer RNA histidine(anticodon GUG)

This record serves to anchor the annotations of this class of tRNAs at multiple locations on the human genome. The placements are predicted using tRNAscan-SE (Lowe, T.M. and Eddy, S.R. 1997. Nucleic Acids Res. 25:955-964, PubMed 9023104).

transfer RNA suppressor (TTA) 1-1

transfer RNA-Leu (CAG) 1-6

transfer RNA-Leu (CAG) 1-7

transfer RNA-Leu (CAG) 1-4

transfer RNA-Leu (CAG) 1-5

transfer RNA-Leu (CAG) 1-2

transfer RNA-Leu (CAG) 1-3

transfer RNA-Leu (CAG) 1-1

transfer RNA tyrosine (anticodon GUA)

This record serves to anchor the annotations of this class of tRNAs at multiple locations on the human genome. The placements are predicted using tRNAscan-SE (Lowe, T.M. and Eddy, S.R. 1997. Nucleic Acids Res. 25:955-964, PubMed 9023104).

transfer RNA-Ala (AGC) 10-1

transfer RNA-Thr (AGT) 4-1

transfer RNA-Arg (TCT) 1-1

transfer RNA-Asn (GTT) 9-2

transfer RNA-Ser (TGA) 1-1

transfer RNA-Gln (CTG) 9-1

transfer RNA-Arg (TCT) 4-1

transfer RNA-Lys (TTT) 3-1

transfer RNA-Lys (TTT) 3-2

transfer RNA-Lys (TTT) 3-3

transfer RNA-Lys (TTT) 3-4

transfer RNA-Gln (CTG) 15-1

transfer RNA-Met (CAT) 2-1

transfer RNA-Tyr (GTA) 10-1

transfer RNA leucine (anticodon UAG)

This record serves to anchor the annotations of this class of tRNAs at multiple locations on the human genome. The placements are predicted using tRNAscan-SE (Lowe, T.M. and Eddy, S.R. 1997. Nucleic Acids Res. 25:955-964, PubMed 9023104).

transfer RNA-Arg (TCG) 1-1

transfer RNA-Ala (AGC) 1-1

transfer RNA-Arg (TCT) 5-1

nuclear-encoded mitochondrial transfer RNA-Gln (TTG) 8-1

transfer RNA-Arg (CCT) 1-1

transfer RNA-Gln (CTG) 14-1

transfer RNA-Met (CAT) 3-2

transfer RNA-Met (CAT) 3-1

transfer RNA-Met (CAT) 6-1

transfer RNA-Val (CAC) 5-1

transfer RNA-His (GTG) 1-7

transfer RNA-His (GTG) 1-6

transfer RNA-His (GTG) 1-5

transfer RNA-His (GTG) 1-4

transfer RNA-His (GTG) 1-1

transfer RNA-Ser (CGA) 3-1

transfer RNA-Glu (CTC) 8-1

transfer RNA arginine (anticodon UCU)

This record serves to anchor the annotations of this class of tRNAs at multiple locations on the human genome. The placements are predicted using tRNAscan-SE (Lowe, T.M. and Eddy, S.R. 1997. Nucleic Acids Res. 25:955-964, PubMed 9023104).

transfer RNA-Phe (GAA) 12-1

transfer RNA arginine (anticodon UCG)

This record serves to anchor the annotations of this class of tRNAs at multiple locations on the human genome. The placements are predicted using tRNAscan-SE (Lowe, T.M. and Eddy, S.R. 1997. Nucleic Acids Res. 25:955-964, PubMed 9023104).

transfer RNA-Phe (GAA) 8-1

transfer RNA-Ile (TAT) 1-1

transfer RNA-Ile (AAT) 4-1

transfer RNA-Glu (TTC) 3-1

transfer RNA-Leu (TAA) 1-1

transfer RNA-Arg (ACG) 1-1

transfer RNA-Arg (ACG) 1-2

glycolipid transfer protein

The protein encoded by this gene is similar to bovine and porcine proteins which accelerate transfer of certain glycosphingolipids and glyceroglycolipids between membranes. It is thought to be a cytoplasmic protein. [provided by RefSeq, Jul 2008]

transfer RNA-Lys (CTT) 13-1

transfer RNA-Val (CAC) 1-1

transfer RNA-Val (CAC) 1-2

transfer RNA-Val (CAC) 1-3

transfer RNA-Val (CAC) 1-5

transfer RNA-Val (CAC) 1-6

transfer RNA-Ser (AGA) 7-1

transfer RNA-Glu (TTC) 2-1

nuclear-encoded mitochondrial transfer RNA-Gln (TTG) 2-1

transfer RNA-Ile (AAT) 5-2

transfer RNA-Ile (AAT) 5-3

transfer RNA-Ile (AAT) 5-1

transfer RNA-Ile (AAT) 5-4

transfer RNA-Ile (AAT) 5-5

transfer RNA alanine (anticodon CGC)

This record serves to anchor the annotations of this class of tRNAs at multiple locations on the human genome. The placements are predicted using tRNAscan-SE (Lowe, T.M. and Eddy, S.R. 1997. Nucleic Acids Res. 25:955-964, PubMed 9023104).

transfer RNA arginine (anticodon CCU)

This record serves to anchor the annotations of this class of tRNAs at multiple locations on the human genome. The placements are predicted using tRNAscan-SE (Lowe, T.M. and Eddy, S.R. 1997. Nucleic Acids Res. 25:955-964, PubMed 9023104).

transfer RNA arginine (anticodon CCG)

This record serves to anchor the annotations of this class of tRNAs at multiple locations on the human genome. The placements are predicted using tRNAscan-SE (Lowe, T.M. and Eddy, S.R. 1997. Nucleic Acids Res. 25:955-964, PubMed 9023104).

transfer RNA-Leu (CAA) 6-1

transfer RNA-Ala (CGC) 3-1

transfer RNA-Tyr (GTA) 1-1

transfer RNA-Glu (CTC) 18-1

transfer RNA-Glu (TTC) 16-1

transfer RNA-Leu (TAA) 4-1

transfer RNA-Pro (AGG) 6-1

transfer RNA-Leu (CAA) 7-1

transfer RNA-Ser (CGA) 2-1

transfer RNA glutamic acid (anticodon UUC)

This record serves to anchor the annotations of this class of tRNAs at multiple locations on the human genome. The placements are predicted using tRNAscan-SE (Lowe, T.M. and Eddy, S.R. 1997. Nucleic Acids Res. 25:955-964, PubMed 9023104).

transfer RNA-Glu (CTC) 9-1

transfer RNA-Cys (GCA) 9-3

transfer RNA-Cys (GCA) 9-2

transfer RNA-Cys (GCA) 9-1

transfer RNA-Glu (TTC) 12-1

transfer RNA-Cys (GCA) 15-1

transfer RNA-Cys (GCA) 10-1

nuclear-encoded mitochondrial transfer RNA-Gln (TTG) 3-1

transfer RNA-Asn (GTT) 11-2

transfer RNA-Asn (GTT) 11-1

transfer RNA-Cys (GCA) 8-1

transfer RNA-Glu (TTC) 13-1

transfer RNA-Asn (GTT) 10-1

transfer RNA-Glu (CTC) 15-1

transfer RNA-Thr (AGT) 1-3

transfer RNA-Thr (AGT) 1-2

transfer RNA-Thr (AGT) 1-1

transfer RNA-Ala (CGC) 2-1

transfer RNA-Thr (CGT) 3-1

transfer RNA-Ser (TGA) 4-1

Hong et al. (1992) [PubMed 1549482] sequenced a human serine tRNA by the dideoxysequencing method. Sequence analysis revealed that the gene forms a typical cloverleaf structure with all appropriate conserved bases, and that the anticodon sequence is 5-prime-UGA-3-prime. The gene has no introns and its nucleotide sequence is highly homologous to those of previously characterized serine tRNAs.[supplied by OMIM, Sep 2009]

transfer RNA-undetermined (NNN) 7-1

transfer RNA-Cys (GCA) 21-1

nuclear-encoded mitochondrial transfer RNA-Gln (TTG) 12-1

transfer RNA suppressor (TTA) 2-1

transfer RNA-Glu (CTC) 14-1

transfer RNA-Tyr (ATA) 1-1

transfer RNA-Lys (CTT) 5-1

transfer RNA-Cys (GCA) 20-1

transfer RNA-Gly (GCC) 6-1

transfer RNA-Gln (TTG) 8-1

transfer RNA-Ala (AGC) 2-2

transfer RNA-Asp (GTC) 2-10

transfer RNA-Asp (GTC) 2-11

transfer RNA-Ala (AGC) 11-1

transfer RNA-Lys (CTT) 4-1

transfer RNA tyrosine (anticodon AUA)

This record serves to anchor the annotations of this class of tRNAs at multiple locations on the human genome. The placements are predicted using tRNAscan-SE (Lowe, T.M. and Eddy, S.R. 1997. Nucleic Acids Res. 25:955-964, PubMed 9023104).

nuclear-encoded mitochondrial transfer RNA-Ser (TGA) 2-1

transfer RNA-Lys (TTT) 8-1

transfer RNA-Val (AAC) 6-1

transfer RNA-Ser (AGA) 2-6

transfer RNA-Ile (AAT) 8-1

transfer RNA-Leu (TAG) 4-1

transfer RNA-Asn (GTT) 6-1

transfer RNA-Val (AAC) 1-2

transfer RNA-Val (AAC) 1-3

transfer RNA-Thr (TGT) 3-1

transfer RNA-Val (AAC) 2-1

phosphatidylcholine transfer protein

Enables phosphatidylcholine binding activity and phosphatidylcholine transporter activity. Involved in phospholipid transport. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Mar 2025]

transfer RNA-Lys (TTT) 9-1

transfer RNA-Gly (GCC) 2-2

transfer RNA-Asn (GTT) 7-1

nuclear-encoded mitochondrial transfer RNA-Gln (TTG) 6-1

transfer RNA-Asn (GTT) 22-1

transfer RNA serine (anticodon CGA)

This record serves to anchor the annotations of this class of tRNAs at multiple locations on the human genome. The placements are predicted using tRNAscan-SE (Lowe, T.M. and Eddy, S.R. 1997. Nucleic Acids Res. 25:955-964, PubMed 9023104).

transfer RNA valine (anticodon UAC)

This record serves to anchor the annotations of this class of tRNAs at multiple locations on the human genome. The placements are predicted using tRNAscan-SE (Lowe, T.M. and Eddy, S.R. 1997. Nucleic Acids Res. 25:955-964, PubMed 9023104).

transfer RNA-Tyr (GTA) 5-2

transfer RNA-Tyr (GTA) 5-3

transfer RNA-Tyr (GTA) 5-1

transfer RNA-Tyr (GTA) 5-4

transfer RNA-Tyr (GTA) 5-5

nuclear-encoded mitochondrial transfer RNA-Gln (TTG) 13-1

transfer RNA-Lys (CTT) 9-1

transfer RNA-Pro (TGG) 3-5

transfer RNA-Pro (TGG) 3-4

transfer RNA-Pro (TGG) 3-3

transfer RNA-Pro (TGG) 3-2

transfer RNA-Pro (TGG) 3-1

transfer RNA glycine (anticodon CCC)

This record serves to anchor the annotations of this class of tRNAs at multiple locations on the human genome. The placements are predicted using tRNAscan-SE (Lowe, T.M. and Eddy, S.R. 1997. Nucleic Acids Res. 25:955-964, PubMed 9023104).

transfer RNA glutamine (anticodon UUG)

This record serves to anchor the annotations of this class of tRNAs at multiple locations on the human genome. The placements are predicted using tRNAscan-SE (Lowe, T.M. and Eddy, S.R. 1997. Nucleic Acids Res. 25:955-964, PubMed 9023104).

phosphatidylinositol transfer protein, alpha

This gene encodes a member of a family of lipid-binding proteins that transfer molecules of phosphatidylinositol or phosphatidylcholine between membrane surfaces. The protein is implicated in phospholipase C signaling and in the production of phosphatidylinositol 3,4,5-trisphosphate (PIP3) by phosphoinositide-3-kinase.[provided by RefSeq, Sep 2009]

phosphatidylinositol transfer protein, beta

This gene encodes a cytoplasmic protein that catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes. This transfer activity is required for COPI complex-mediated retrograde transport from the Golgi apparatus to the endoplasmic reticulum. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2013]

transfer RNA-Ala (AGC) 18-1

transfer RNA-Ala (AGC) 18-2

transfer RNA-Ala (AGC) 3-1

nuclear-encoded mitochondrial transfer RNA-Val (TAC) 1-1

transfer RNA-Cys (GCA) 14-1

transfer RNA-Lys (CTT) 8-1

transfer RNA-Lys (TTT) 13-1

transfer RNA ochre suppressor(anticodon UUA)

This record serves to anchor the annotations of this class of tRNAs at multiple locations on the human genome. The placements are predicted using tRNAscan-SE (Lowe, T.M. and Eddy, S.R. 1997. Nucleic Acids Res. 25:955-964, PubMed 9023104).

nuclear-encoded mitochondrial transfer RNA-Leu (TAA) 4-1

transfer RNA-Pro (TGG) 2-1

transfer RNA-Asp (GTC) 2-6

transfer RNA-Asp (GTC) 2-7

transfer RNA-Asp (GTC) 2-2

transfer RNA-Asp (GTC) 2-3

transfer RNA-Asp (GTC) 2-8

transfer RNA-Val (AAC) 3-1

transfer RNA-Lys (TTT) 12-1

transfer RNA-Ala (AGC) 14-1

transfer RNA-Ala (TGC) 4-1

nuclear-encoded mitochondrial transfer RNA-Leu (TAA) 5-1

transfer RNA-Gln (CTG) 4-1

transfer RNA-Gln (CTG) 4-2

transfer RNA methionine (anticodon CAU)

This record serves to anchor the annotations of this class of tRNAs at multiple locations on the human genome. The placements are predicted using tRNAscan-SE (Lowe, T.M. and Eddy, S.R. 1997. Nucleic Acids Res. 25:955-964, PubMed 9023104).

nuclear-encoded mitochondrial transfer RNA-Gln (TTG) 7-1

transfer RNA leucine 47 (anticodon AAG) pseudogene

transfer RNA-undetermined (NNN) 2-1

transfer RNA phenylalanine (anticodon GAA)

This record serves to anchor the annotations of this class of tRNAs at multiple locations on the human genome. The placements are predicted using tRNAscan-SE (Lowe, T.M. and Eddy, S.R. 1997. Nucleic Acids Res. 25:955-964, PubMed 9023104).

transfer RNA-Leu (AAG) 2-3

transfer RNA-Leu (AAG) 2-2

transfer RNA-Leu (AAG) 2-1

transfer RNA-Leu (AAG) 2-4

transfer RNA-Ala (TGC) 5-1

transfer RNA-His (GTG) 1-8

transfer RNA-Ile (AAT) 3-1

transfer RNA-Ile (GAT) 1-1

transfer RNA-Ile (GAT) 1-2

transfer RNA-Ile (GAT) 1-3

transfer RNA-undetermined (NNN) 3-1

transfer RNA-Gln (CTG) 3-2

transfer RNA serine (anticodon AGA)

This record serves to anchor the annotations of this class of tRNAs at multiple locations on the human genome. The placements are predicted using tRNAscan-SE (Lowe, T.M. and Eddy, S.R. 1997. Nucleic Acids Res. 25:955-964, PubMed 9023104).

transfer RNA-Glu (TTC) 7-1

transfer RNA-Ala (AGC) 19-1

transfer RNA-Leu (AAG) 6-1

transfer RNA-Ile (AAT) 12-1

transfer RNA-Gln (CTG) 1-4

transfer RNA-Gln (CTG) 1-1

transfer RNA-Gln (CTG) 1-2

transfer RNA-Gln (CTG) 1-3

transfer RNA-Gln (TTG) 3-3

transfer RNA-Gln (TTG) 3-2

transfer RNA-Gln (TTG) 3-1

transfer RNA-Arg (CCG) 1-2

transfer RNA-Arg (CCG) 1-3

StAR-related lipid transfer (START) domain containing 10

Predicted to enable lipid binding activity. Predicted to be involved in lipid transport. Predicted to act upstream of or within bile acid secretion and positive regulation of peroxisome proliferator activated receptor signaling pathway. Located in cytosol. [provided by Alliance of Genome Resources, Mar 2025]

StAR-related lipid transfer (START) domain containing 13

This gene encodes a protein which contains an N-terminal sterile alpha motif (SAM) for protein-protein interactions, followed by an ATP/GTP-binding motif, a GTPase-activating protein (GAP) domain, and a C-terminal STAR-related lipid transfer (START) domain. It may be involved in regulation of cytoskeletal reorganization, cell proliferation, and cell motility, and acts as a tumor suppressor in hepatoma cells. The gene is located in a region of chromosome 13 that is associated with loss of heterozygosity in hepatocellular carcinomas. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

transfer RNA-Arg (CCT) 4-1

StAR-related lipid transfer (START) domain containing 9

Enables microtubule binding activity and microtubule motor activity. Involved in spindle assembly. Located in centriole; cytoplasm; and nucleus. [provided by Alliance of Genome Resources, Mar 2025]

glycolipid transfer protein domain containing 2

Predicted to enable ceramide 1-phosphate binding activity and ceramide 1-phosphate transfer activity. Predicted to be involved in ceramide transport and intermembrane lipid transfer. Predicted to be located in cytoplasm. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Mar 2025]

StAR-related lipid transfer (START) domain containing 4

Cholesterol homeostasis is regulated, at least in part, by sterol regulatory element (SRE)-binding proteins (e.g., SREBP1; MIM 184756) and by liver X receptors (e.g., LXRA; MIM 602423). Upon sterol depletion, LXRs are inactive and SREBPs are cleaved, after which they bind promoter SREs and activate genes involved in cholesterol biosynthesis and uptake. Sterol transport is mediated by vesicles or by soluble protein carriers, such as steroidogenic acute regulatory protein (STAR; MIM 600617). STAR is homologous to a family of proteins containing a 200- to 210-amino acid STAR-related lipid transfer (START) domain, including STARD4 (Soccio et al., 2002 [PubMed 12011452]).[supplied by OMIM, Mar 2008]

StAR-related lipid transfer (START) domain containing 5

Proteins containing a steroidogenic acute regulatory-related lipid transfer (START) domain are often involved in the trafficking of lipids and cholesterol between diverse intracellular membranes. This gene is a member of the StarD subfamily that encodes START-related lipid transfer proteins. The protein encoded by this gene is a cholesterol transporter and is also able to bind and transport other sterol-derived molecules related to the cholesterol/bile acid biosynthetic pathways such as 25-hydroxycholesterol. Its expression is upregulated during endoplasmic reticulum (ER) stress. The protein is thought to act as a cytosolic sterol transporter that moves cholesterol between intracellular membranes such as from the cytoplasm to the ER and from the ER to the Golgi apparatus. Alternative splicing of this gene produces multiple transcript variants. [provided by RefSeq, Jan 2016]

transfer RNA valine (anticodon CAC)

This record serves to anchor the annotations of this class of tRNAs at multiple locations on the human genome. The placements are predicted using tRNAscan-SE (Lowe, T.M. and Eddy, S.R. 1997. Nucleic Acids Res. 25:955-964, PubMed 9023104).

transfer RNA-Leu (CAA) 1-1

transfer RNA-Leu (CAA) 1-2

transfer RNA-Ala (AGC) 15-1

transfer RNA-Gln (TTG) 2-1

transfer RNA-Gln (CTG) 5-1

transfer RNA-Gly (GCC) 1-5

transfer RNA-Gly (GCC) 1-1

transfer RNA-Gly (GCC) 1-3

transfer RNA-Gly (GCC) 1-2

transfer RNA-Thr (TGT) 6-1

transfer RNA-Phe (GAA) 4-1

transfer RNA suppressor (TTA) 3-1

cholesteryl ester transfer protein, plasma

The protein encoded by this gene is found in plasma, where it is involved in the transfer of cholesteryl ester from high density lipoprotein (HDL) to other lipoproteins. Defects in this gene are a cause of hyperalphalipoproteinemia 1 (HALP1). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]

transfer RNA-Ala (AGC) 2-1

transfer RNA-Arg (TCG) 5-1

transfer RNA-Lys (CTT) 3-1

transfer RNA-Gly (TCC) 2-4

transfer RNA-Arg (CCT) 7-1

transfer RNA-Thr (TGT) 2-1

transfer RNA-Pro (AGG) 4-1

transfer RNA-Ser (AGA) 3-1

transfer RNA-Ser (AGA) 2-1

transfer RNA-Arg (TCG) 4-1

transfer RNA-Glu (CTC) 4-1

transfer RNA-Asn (GTT) 16-1

transfer RNA-Asn (GTT) 16-3

transfer RNA-Asn (GTT) 16-2

transfer RNA-Asn (GTT) 16-5

transfer RNA-Asn (GTT) 16-4

transfer RNA-Cys (GCA) 1-1

transfer RNA-Pro (AGG) 5-1

transfer RNA-Lys (CTT) 14-1

transfer RNA-Val (CAC) 13-1

transfer RNA-undetermined (NNN) 1-1

transfer RNA-Ser (AGA) 2-4

Hoe et al. (1987) [PubMed 3697066] sequenced a human serine (AGA) tRNA by the dideoxysequencing method and compared it with previously sequenced serine tRNAs.[supplied by OMIM, Sep 2009]

transfer RNA-Ser (AGA) 2-5

transfer RNA-Ser (AGA) 2-2

transfer RNA-Ser (AGA) 2-3

transfer RNA-Ser (GCT) 1-1

transfer RNA-Leu (CAA) 3-1

transfer RNA isoleucine (anticodon UAU)

This record serves to anchor the annotations of this class of tRNAs at multiple locations on the human genome. The placements are predicted using tRNAscan-SE (Lowe, T.M. and Eddy, S.R. 1997. Nucleic Acids Res. 25:955-964, PubMed 9023104).

ceramide-1-phosphate transfer protein

Enables ceramide 1-phosphate binding activity and ceramide 1-phosphate transfer activity. Involved in ceramide 1-phosphate transport; negative regulation of NLRP3 inflammasome complex assembly; and negative regulation of metabolic process. Located in cytosol. [provided by Alliance of Genome Resources, Mar 2025]

transfer RNA-Glu (TTC) 6-1

transfer RNA-Ala (CGC) 1-1

transfer RNA-iMet (CAT) 3-1

transfer RNA-Val (CAC) 10-1

transfer RNA-Gly (TCC) 3-1

transfer RNA-Ile (AAT) 6-1

transfer RNA-Glu (CTC) 1-7

transfer RNA-Glu (CTC) 1-1

transfer RNA-Glu (CTC) 1-2

transfer RNA-Tyr (GTA) 2-1

transfer RNA-Lys (CTT) 2-1

transfer RNA-Lys (CTT) 2-2

transfer RNA-Lys (CTT) 2-3

transfer RNA-Lys (CTT) 2-5

transfer RNA-Ala (AGC) 23-1

transfer RNA-Pro (AGG) 2-3

transfer RNA-Pro (AGG) 2-8

transfer RNA-Leu (CAA) 4-1

transfer RNA-Gly (GCC) 1-4

transfer RNA-Ala (TGC) 8-1

transfer RNA-Trp (CCA) 7-1

transfer RNA-Asp (GTC) 9-1

transfer RNA-Val (CAC) 12-1

transfer RNA-SeC (TCA) 1-1

Opal suppressor phosphoserine tRNAs are the only authentic, naturally occurring suppressor tRNAs in higher eukaryotes. The human genome contains a single opal suppressor phosphoserine tRNA gene, TRNAU1 (O'Neill et al., 1985 [PubMed 3156131]).[supplied by OMIM, Nov 2010]

transfer RNA-Asn (ATT) 1-2

nuclear-encoded mitochondrial transfer RNA-Ser (TGA) 1-1

phosphatidylinositol transfer protein, cytoplasmic 1 pseudogene

transfer RNA-Ile (AAT) 7-1

transfer RNA-Ile (AAT) 7-2

transfer RNA alanine (anticodon UGC)

This record serves to anchor the annotations of this class of tRNAs at multiple locations on the human genome. The placements are predicted using tRNAscan-SE (Lowe, T.M. and Eddy, S.R. 1997. Nucleic Acids Res. 25:955-964, PubMed 9023104).

transfer RNA-Arg (TCG) 2-1

transfer RNA-Cys (GCA) 4-1

transfer RNA-Thr (CGT) 1-1

transfer RNA-Asp (GTC) 8-1

transfer RNA-Asn (GTT) 20-1

transfer RNA-iMet (CAT) 2-1

Santos and Zasloff (1981) [PubMed 6261953] identified 12 initiator methionine tRNA genes, symbolized tRNA-i(met), in the haploid human genome. Zasloff et al. (1982) [PubMed 6923137] found a variant tRNA-i(met) with a G-to-T transversion in the highly conserved TCGA sequence in loop 4, a sequence position occupied exclusively by a purine (usually G) in almost 200 prokaryotic and eukaryotic tRNAs. One functional consequence of this base substitution is reduction in the rate of processing of the primary transcript of the gene. A second, demonstrated by microinjection into the germinal vesicle of the intact Xenopus laevis oocyte, is blockage of egress from the nucleus. It has been estimated that the human haploid genome contains 1,000 to 2,000 tRNA genes and that there are 50 to 60 chromatographically distinct tRNA species. These observations suggest redundancy of some tRNA genes. The studies of initiator methionine tRNA genes bear out this suspicion.[supplied by OMIM, Sep 2009]

transfer RNA-undetermined (NNN) 10-1

transfer RNA-Leu (TAG) 3-1

transfer RNA-Phe (GAA) 10-1

transfer RNA-undetermined (NNN) 5-1

transfer RNA-Ala (AGC) 4-1

nuclear-encoded mitochondrial transfer RNA-Gln (TTG) 11-1

transfer RNA-Gly (CCC) 4-1

transfer RNA-undetermined (NNN) 4-1

transfer RNA-Cys (GCA) 5-1

transfer RNA-Asn (GTT) 21-1

transfer RNA-Ser (GCT) 4-1

transfer RNA-Ser (GCT) 4-3

transfer RNA-Ser (GCT) 4-2

tocopherol (alpha) transfer protein-like

Predicted to enable phosphatidylinositol bisphosphate binding activity. Located in membrane. [provided by Alliance of Genome Resources, Mar 2025]

transfer RNA-Asn (ATT) 1-1

transfer RNA-Leu (AAG) 3-1

transfer RNA-Thr (TGT) 4-1

transfer RNA-Pro (AGG) 3-1

transfer RNA-Leu (CAA) 5-1

transfer RNA-Ala (AGC) 7-1

transfer RNA-Phe (GAA) 6-1

transfer RNA-Gly (CCC) 6-1

transfer RNA-Cys (GCA) 23-1

transfer RNA-Lys (CTT) 12-1

transfer RNA-Trp (CCA) 6-1

transfer RNA-Gly (GCC) 5-1

transfer RNA-Ala (AGC) 6-1

transfer RNA-Leu (CAG) 2-1

transfer RNA-Leu (CAG) 2-2

transfer RNA-Arg (ACG) 2-4

transfer RNA-Arg (ACG) 2-3

transfer RNA-Arg (ACG) 2-2

transfer RNA-Arg (ACG) 2-1

transfer RNA-Phe (GAA) 2-1

nuclear-encoded mitochondrial transfer RNA-Leu (TAA) 3-1

transfer RNA-Lys (TTT) 1-1

transfer RNA-Gly (TCC) 1-1

transfer RNA-Ala (TGC) 3-1

transfer RNA-Ala (TGC) 3-2

transfer RNA-Leu (TAG) 2-1

transfer RNA-Asn (GTT) 2-6

transfer RNA-Asn (GTT) 2-5

transfer RNA-Asn (GTT) 2-4

transfer RNA-Asn (GTT) 2-3

transfer RNA-Asn (GTT) 2-2

transfer RNA-Asn (GTT) 2-1

The saturation hybridization studies of Hatlen and Attardi (1971) [PubMed 4929578] indicated a copy number of tRNA genes of 1,300 for the haploid human genome--an average of 65 gene copies for each tRNA species. These genes tend to be clustered, an arrangement that would facilitate the exchange of sequence information and enable them to evolve together.[supplied by OMIM, Sep 2009]

nuclear-encoded mitochondrial transfer RNA-Gln (TTG) 10-1

transfer RNA-Glu (CTC) 1-4

transfer RNA-Glu (CTC) 1-6

transfer RNA-Gln (CTG) 17-1

transfer RNA-Pro (AGG) 2-5

transfer RNA-Gly (TCC) 5-1

transfer RNA-Ser (GCT) 5-1

transfer RNA-Tyr (GTA) 12-1

transfer RNA-Arg (TCG) 3-1

transfer RNA-Asn (GTT) 3-2

transfer RNA-Asn (GTT) 3-1

transfer RNA-Phe (GAA) 11-1

transfer RNA-Lys (CTT) 2-4

transfer RNA-Phe (GAA) 7-1

transfer RNA glutamic acid (anticodon CUC)

This record serves to anchor the annotations of this class of tRNAs at multiple locations on the human genome. The placements are predicted using tRNAscan-SE (Lowe, T.M. and Eddy, S.R. 1997. Nucleic Acids Res. 25:955-964, PubMed 9023104).

transfer RNA-Cys (GCA) 22-1

transfer RNA-Asp (GTC) 10-1

transfer RNA-Met (CAT) 4-1

transfer RNA-Met (CAT) 4-3

transfer RNA-Met (CAT) 4-2

transfer RNA-Val (CAC) 3-1

transfer RNA-His (GTG) 3-1

transfer RNA-Gly (GCC) 4-1

transfer RNA-Val (CAC) 14-1

transfer RNA isoleucine (anticodon GAU)

This record serves to anchor the annotations of this class of tRNAs at multiple locations on the human genome. The placements are predicted using tRNAscan-SE (Lowe, T.M. and Eddy, S.R. 1997. Nucleic Acids Res. 25:955-964, PubMed 9023104).

transfer RNA-Leu (CAG) 3-1

transfer RNA-Glu (TTC) 1-1

transfer RNA-Glu (TTC) 1-2

transfer RNA-Phe (GAA) 3-1

nuclear-encoded mitochondrial transfer RNA-Gln (TTG) 9-1

transfer RNA-Lys (CTT) 15-1

transfer RNA-Pro (CGG) 1-1

transfer RNA-Pro (CGG) 1-2

transfer RNA-Pro (CGG) 1-3

transfer RNA opal suppressor (anticodon UCA)

This record serves to anchor the annotations of this class of tRNAs at multiple locations on the human genome. The placements are predicted using tRNAscan-SE (Lowe, T.M. and Eddy, S.R. 1997. Nucleic Acids Res. 25:955-964, PubMed 9023104).

transfer RNA-Asn (GTT) 9-1

tocopherol (alpha) transfer protein

This gene encodes a soluble protein that binds alpha-trocopherol, a form of vitamin E, with high selectivity and affinity. This protein plays an important role in regulating vitamin E levels in the body by transporting vitamin E between membrane vesicles and facilitating the secretion of vitamin E from hepatocytes to circulating lipoproteins. Mutations in this gene cause hereditary vitamin E deficiency (ataxia with vitamin E deficiency, AVED) and retinitis pigmentosa. [provided by RefSeq, Nov 2009]

transfer RNA-Ala (AGC) 17-1

transfer RNA suppressor (CTA) 3-1

transfer RNA-Ala (AGC) 5-1

transfer RNA-Trp (CCA) 3-3

transfer RNA-Trp (CCA) 3-2

transfer RNA cysteine (anticodon GCA)

This record serves to anchor the annotations of this class of tRNAs at multiple locations on the human genome. The placements are predicted using tRNAscan-SE (Lowe, T.M. and Eddy, S.R. 1997. Nucleic Acids Res. 25:955-964, PubMed 9023104).

transfer RNA proline (anticodon CGG)

This record serves to anchor the annotations of this class of tRNAs at multiple locations on the human genome. The placements are predicted using tRNAscan-SE (Lowe, T.M. and Eddy, S.R. 1997. Nucleic Acids Res. 25:955-964, PubMed 9023104).

transfer RNA-Trp (CCA) 1-1

transfer RNA-Asp (GTC) 5-1

transfer RNA-Gln (CTG) 16-1

transfer RNA-Met (CAT) 1-1

transfer RNA suppressor (CTA) 2-1

electron-transfer-flavoprotein, alpha polypeptide

ETFA participates in catalyzing the initial step of the mitochondrial fatty acid beta-oxidation. It shuttles electrons between primary flavoprotein dehydrogenases and the membrane-bound electron transfer flavoprotein ubiquinone oxidoreductase. Defects in electron-transfer-flavoprotein have been implicated in type II glutaricaciduria in which multiple acyl-CoA dehydrogenase deficiencies result in large excretion of glutaric, lactic, ethylmalonic, butyric, isobutyric, 2-methyl-butyric, and isovaleric acids. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

electron-transfer-flavoprotein, beta polypeptide

This gene encodes electron-transfer-flavoprotein, beta polypeptide, which shuttles electrons between primary flavoprotein dehydrogenases involved in mitochondrial fatty acid and amino acid catabolism and the membrane-bound electron transfer flavoprotein ubiquinone oxidoreductase. The gene deficiencies have been implicated in type II glutaricaciduria. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]

transfer RNA-Ala (AGC) 12-3

transfer RNA-Ser (AGA) 5-1

transfer RNA-Val (TAC) 3-1

transfer RNA-Lys (TTT) 10-1

nuclear-encoded mitochondrial transfer RNA-Leu (TAA) 6-1

transfer RNA-Thr (CGT) 5-1

transfer RNA-Ala (AGC) 22-1

transfer RNA-Pro (AGG) 2-1

transfer RNA-Pro (AGG) 2-2

transfer RNA-Pro (AGG) 2-4

transfer RNA-Pro (AGG) 2-7

transfer RNA-Met (CAT) 5-1

transfer RNA-Lys (TTT) 3-5

transfer RNA-His (GTG) 2-1

transfer RNA-Cys (GCA) 16-1

transfer RNA-Ser (CGA) 4-1

transfer RNA-Ala (TGC) 6-1

transfer RNA-Gly (CCC) 3-1

transfer RNA-His (GTG) 1-3

transfer RNA-Thr (CGT) 6-1

transfer RNA-Glu (TTC) 10-1

transfer RNA-Leu (TAA) 3-1

transfer RNA-Leu (AAG) 7-1

transfer RNA aspartic acid (anticodon GUC)

This record serves to anchor the annotations of this class of tRNAs at multiple locations on the human genome. The placements are predicted using tRNAscan-SE (Lowe, T.M. and Eddy, S.R. 1997. Nucleic Acids Res. 25:955-964, PubMed 9023104).

transfer RNA-Cys (GCA) 12-1

transfer RNA-Cys (GCA) 6-1

transfer RNA-Ile (AAT) 11-1

transfer RNA-Arg (CCT) 9-1

transfer RNA-Gly (CCC) 2-1

transfer RNA-Asn (GTT) 13-1

transfer RNA leucine (anticodon CAG)

This record serves to anchor the annotations of this class of tRNAs at multiple locations on the human genome. The placements are predicted using tRNAscan-SE (Lowe, T.M. and Eddy, S.R. 1997. Nucleic Acids Res. 25:955-964, PubMed 9023104).

transfer RNA leucine (anticodon CAA)

This record serves to anchor the annotations of this class of tRNAs at multiple locations on the human genome. The placements are predicted using tRNAscan-SE (Lowe, T.M. and Eddy, S.R. 1997. Nucleic Acids Res. 25:955-964, PubMed 9023104).

transfer RNA-Gly (CCC) 7-1

transfer RNA-Gln (TTG) 7-1

transfer RNA-Trp (CCA) 2-1

transfer RNA-Lys (TTT) 4-1

transfer RNA-Arg (CCG) 2-1

transfer RNA-Arg (CCT) 8-1

transfer RNA-Glu (CTC) 17-1

transfer RNA-Thr (AGT) 3-1

transfer RNA-Ala (CGC) 4-1

transfer RNA-Gln (TTG) 6-1

transfer RNA-Lys (TTT) 5-1

transfer RNA-Thr (CGT) 4-1

transfer RNA glycine (anticodon UCC)

This record serves to anchor the annotations of this class of tRNAs at multiple locations on the human genome. The placements are predicted using tRNAscan-SE (Lowe, T.M. and Eddy, S.R. 1997. Nucleic Acids Res. 25:955-964, PubMed 9023104).

nuclear-encoded mitochondrial transfer RNA-Pro (TGG) 1-1

transfer RNA-Leu (AAG) 8-1

transfer RNA glutamine (anticodon CUG)

This record serves to anchor the annotations of this class of tRNAs at multiple locations on the human genome. The placements are predicted using tRNAscan-SE (Lowe, T.M. and Eddy, S.R. 1997. Nucleic Acids Res. 25:955-964, PubMed 9023104).

transfer RNA-Ala (TGC) 7-1

microsomal triglyceride transfer protein

MTP encodes the large subunit of the heterodimeric microsomal triglyceride transfer protein. Protein disulfide isomerase (PDI) completes the heterodimeric microsomal triglyceride transfer protein, which has been shown to play a central role in lipoprotein assembly. Mutations in MTP can cause abetalipoproteinemia. [provided by RefSeq, Jul 2008]

transfer RNA-Lys (CTT) 7-1

transfer RNA-Arg (TCT) 2-1

Transfer RNA arginine-1 has an anticodon UCU (Morrison et al., 1991 [PubMed 2066114]).[supplied by OMIM, Sep 2009]

transfer RNA-Thr (AGT) 5-1

transfer RNA-Gln (CTG) 13-1

transfer RNA-Val (CAC) 6-1

transfer RNA-Gln (CTG) 11-1

transfer RNA glycine (anticodon GCC)

This record serves to anchor the annotations of this class of tRNAs at multiple locations on the human genome. The placements are predicted using tRNAscan-SE (Lowe, T.M. and Eddy, S.R. 1997. Nucleic Acids Res. 25:955-964, PubMed 9023104).

transfer RNA-Ala (AGC) 13-2

transfer RNA-Ile (AAT) 10-1

transfer RNA-Asn (GTT) 12-1

transfer RNA-Gln (CTG) 10-1

transfer RNA-Val (CAC) 7-1

transfer RNA-Lys (CTT) 10-1

transfer RNA-Ile (AAT) 2-1

transfer RNA-Val (CAC) 2-1

transfer RNA-Ser (AGA) 6-1

transfer RNA proline (anticodon UGG)

This record serves to anchor the annotations of this class of tRNAs at multiple locations on the human genome. The placements are predicted using tRNAscan-SE (Lowe, T.M. and Eddy, S.R. 1997. Nucleic Acids Res. 25:955-964, PubMed 9023104).

transfer RNA-Glu (TTC) 5-1

transfer RNA-Asn (GTT) 4-1

transfer RNA-Glu (CTC) 16-1

transfer RNA-Thr (AGT) 2-2

transfer RNA-Lys (CTT) 11-1

transfer RNA serine (anticodon UGA)

This record serves to anchor the annotations of this class of tRNAs at multiple locations on the human genome. The placements are predicted using tRNAscan-SE (Lowe, T.M. and Eddy, S.R. 1997. Nucleic Acids Res. 25:955-964, PubMed 9023104).

transfer RNA threonine (anticodon AGU)

This record serves to anchor the annotations of this class of tRNAs at multiple locations on the human genome. The placements are predicted using tRNAscan-SE (Lowe, T.M. and Eddy, S.R. 1997. Nucleic Acids Res. 25:955-964, PubMed 9023104).

transfer RNA-Val (TAC) 4-1

transfer RNA-Leu (TAA) 2-1

transfer RNA leucine (anticodon UAA)

This record serves to anchor the annotations of this class of tRNAs at multiple locations on the human genome. The placements are predicted using tRNAscan-SE (Lowe, T.M. and Eddy, S.R. 1997. Nucleic Acids Res. 25:955-964, PubMed 9023104).

transfer RNA-Tyr (GTA) 6-1

transfer RNA-Ile (AAT) 9-1

transfer RNA-Lys (CTT) 6-1

transfer RNA-Thr (AGT) 6-1

transfer RNA-Arg (TCT) 3-1

transfer RNA-Arg (TCT) 3-2

transfer RNA-Val (AAC) 1-1

transfer RNA-Ser (AGA) 1-1

transfer RNA-Gln (CTG) 12-1

transfer RNA-Val (CAC) 8-1

transfer RNA-His (GTG) 1-9

transfer RNA-His (GTG) 1-2

transfer RNA-Gln (CTG) 8-1

transfer RNA-Phe (GAA) 9-1

transfer RNA-Arg (TCG) 6-1

transfer RNA-Ile (TAT) 3-1

transfer RNA-Val (CAC) 11-2

transfer RNA-Pro (GGG) 1-1

transfer RNA-Val (AAC) 1-4

There appear to be about 1,300 tRNA genes in the human genome (Hatlen and Attardi, 1971 [PubMed 4929578]). Arnold et al. (1986) [PubMed 3023191] detected a minimum of 13 valine tRNA genes in genomic blots of human DNA.[supplied by OMIM, Sep 2009]

transfer RNA-Val (AAC) 1-5

nuclear-encoded mitochondrial transfer RNA-Leu (TAA) 2-1

transfer RNA-Lys (TTT) 11-1

transfer RNA-Ile (TAT) 2-2

transfer RNA-Ile (TAT) 2-3

transfer RNA-Ile (TAT) 2-1

transfer RNA arginine

transfer RNA-Glu (TTC) 4-1

transfer RNA-Glu (TTC) 4-2

transfer RNA-Cys (GCA) 7-1

transfer RNA-Pro (TGG) 5-1

transfer RNA-Asp (GTC) 4-1

transfer RNA-Glu (TTC) 14-1

transfer RNA-Glu (CTC) 5-1

nuclear-encoded mitochondrial transfer RNA-Gln (TTG) 1-1

nuclear-encoded mitochondrial transfer RNA-Gln (TTG) 15-1

transfer RNA-Val (AAC) 7-1

transfer RNA-Tyr (GTA) 7-1

transfer RNA-Asn (GTT) 19-1

transfer RNA-Val (CAC) 9-1

transfer RNA-Gly (GCC) 2-3

transfer RNA-Gly (GCC) 2-1

transfer RNA-Ala (AGC) 16-1

transfer RNA-Glu (CTC) 13-1

transfer RNA-Ala (CGC) 5-1

transfer RNA-Glu (CTC) 11-1

transfer RNA-Leu (TAA) 5-1

transfer RNA-Val (TAC) 1-1

transfer RNA-Val (TAC) 1-2

transfer RNA-Ala (AGC) 12-2

transfer RNA-Ala (AGC) 12-1

transfer RNA-Gln (CTG) 7-1

transfer RNA-Glu (CTC) 10-1

transfer RNA-Gln (TTG) 1-1

Mammalian cells contain at least 2 species of glutamine tRNA, the Gln(CUG) form (TRQ1; MIM 189919) and the Gln(UUG) form. Nemoto et al. (1991) [PubMed 2041751] reported the nucleotide sequence of the human tRNA(Gln/UUG) gene. In a correction, Nemoto et al. (1991) [PubMed 2041751] stated that the gene involved should have been designated tRNA-GLN/U*UG, where U* is a derivative of U.[supplied by OMIM, Sep 2009]

transfer RNA-Pro (TGG) 4-1

transfer RNA-Glu (TTC) 15-1

transfer RNA-Arg (CCT) 3-1

transfer RNA-Val (TAC) 2-1

transfer RNA-Ser (ACT) 1-1

transfer RNA-Ala (AGC) 13-1

phosphatidylinositol transfer protein, membrane-associated 1

PITPNM1 belongs to a family of membrane-associated phosphatidylinositol transfer domain-containing proteins that share homology with the Drosophila retinal degeneration B (rdgB) protein (Ocaka et al., 2005 [PubMed 15627748]).[supplied by OMIM, Mar 2008]

phosphatidylinositol transfer protein, membrane-associated 2

PITPNM2 belongs to a family of membrane-associated phosphatidylinositol transfer domain-containing proteins that share homology with the Drosophila retinal degeneration B (rdgB) protein (Ocaka et al., 2005 [PubMed 15627748]).[supplied by OMIM, Mar 2008]

nuclear-encoded mitochondrial transfer RNA-Gln (TTG) 14-1

transfer RNA-Ala (TGC) 2-1

transfer RNA-Thr (AGT) 2-1

transfer RNA-Leu (AAG) 1-1

transfer RNA-Leu (AAG) 1-2

transfer RNA-Leu (AAG) 1-3

transfer RNA-Val (CAC) 1-4

transfer RNA-Cys (GCA) 18-1

transfer RNA-Glu (CTC) 12-1

transfer RNA-Pro (AGG) 2-6

transfer RNA-Cys (GCA) 19-1

transfer RNA-Asn (GTT) 18-1

transfer RNA-Asp (GTC) 2-4

transfer RNA-Asp (GTC) 2-5

transfer RNA-Tyr (GTA) 11-1

transfer RNA-Tyr (GTA) 3-1

transfer RNA-Asp (GTC) 2-1

transfer RNA-Gly (CCC) 8-1

transfer RNA-Glu (TTC) 2-2

transfer RNA-Cys (GCA) 17-1

transfer RNA threonine (anticodon CGU)

This record serves to anchor the annotations of this class of tRNAs at multiple locations on the human genome. The placements are predicted using tRNAscan-SE (Lowe, T.M. and Eddy, S.R. 1997. Nucleic Acids Res. 25:955-964, PubMed 9023104).

transfer RNA-Lys (CTT) 16-1

transfer RNA-Val (AAC) 4-1

transfer RNA-Arg (CCT) 2-1

transfer RNA-undetermined (NNN) 9-1

transfer RNA-Arg (ACG) 1-3

transfer RNA-Asp (GTC) 1-1

transfer RNA-Thr (AGT) 7-1

transfer RNA-Thr (TGT) 5-1

transfer RNA-Val (AAC) 5-1

transfer RNA-SeC (TCA) 2-1

transfer RNA-Gly (TCC) 4-1

transfer RNA-Lys (TTT) 15-1

transfer RNA-Glu (CTC) 7-1

transfer RNA-Ser (CGA) 1-1

transfer RNA-Asn (GTT) 1-1

transfer RNA-Pro (TGG) 1-1

transfer RNA-SeC (TCA) 3-1

transfer RNA-Asp (GTC) 3-1

transfer RNA-Asp (GTC) 2-9

transfer RNA-Thr (TGT) 1-1

transfer RNA-Lys (TTT) 16-1

transfer RNA-Met (CAT) 7-1

transfer RNA-Cys (ACA) 1-1

transfer RNA-Tyr (GTA) 4-1

transfer RNA-Ile (AAT) 1-1

transfer RNA-Ala (TGC) 9-1

transfer RNA-Glu (TTC) 11-1

transfer RNA-Gln (CTG) 2-1

transfer RNA-Trp (CCA) 3-1

transfer RNA-Leu (CAA) 2-1

transfer RNA-Lys (TTT) 14-1

transfer RNA-Gln (CTG) 3-1

transfer RNA-Gln (TTG) 5-1

transfer RNA-Tyr (GTA) 8-1

transfer RNA-Gln (CTG) 6-1

StAR-related lipid transfer (START) domain containing 8

This gene encodes a member of a subfamily of Rho GTPase activating proteins that contain a steroidogenic acute regulatory protein related lipid transfer domain. The encoded protein localizes to focal adhesions and may be involved in regulating cell morphology. This protein may also function as a tumor suppressor. [provided by RefSeq, Mar 2010]

StAR-related lipid transfer (START) domain containing 3

This gene encodes a member of a subfamily of lipid trafficking proteins that are characterized by a C-terminal steroidogenic acute regulatory domain and an N-terminal metastatic lymph node 64 domain. The encoded protein localizes to the membranes of late endosomes and may be involved in exporting cholesterol. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]

StAR-related lipid transfer (START) domain containing 6

Cholesterol homeostasis is regulated, at least in part, by sterol regulatory element (SRE)-binding proteins (e.g., SREBP1; MIM 184756) and by liver X receptors (e.g., LXRA; MIM 602423). Upon sterol depletion, LXRs are inactive and SREBPs are cleaved, after which they bind promoter SREs and activate genes involved in cholesterol biosynthesis and uptake. Sterol transport is mediated by vesicles or by soluble protein carriers, such as steroidogenic acute regulatory protein (STAR; MIM 600617). STAR is homologous to a family of proteins containing a 200- to 210-amino acid STAR-related lipid transfer (START) domain, including STARD6 (Soccio et al., 2002 [PubMed 12011452]).[supplied by OMIM, Mar 2008]

StAR-related lipid transfer (START) domain containing 7

Predicted to enable lipid transfer activity. Predicted to be involved in ubiquinone biosynthetic process. Predicted to act upstream of or within several processes, including establishment of skin barrier; mucociliary clearance; and myeloid dendritic cell activation. Located in mitochondrion. Implicated in familial adult myoclonic epilepsy 2. [provided by Alliance of Genome Resources, Mar 2025]

transfer RNA-Asn (GTT) 5-1

transfer RNA-Ala (AGC) 20-1

transfer RNA-Tyr (GTA) 9-1

transfer RNA-Cys (GCA) 13-1

transfer RNA-Ser (GCT) 6-1

transfer RNA-Glu (CTC) 1-5

transfer RNA-Glu (CTC) 1-3

transfer RNA-Asn (GTT) 15-1

transfer RNA-undetermined (NNN) 8-1

transfer RNA-Asp (GTC) 7-1

transfer RNA lysine (anticodon UUU)

This record serves to anchor the annotations of this class of tRNAs at multiple locations on the human genome. The placements are predicted using tRNAscan-SE (Lowe, T.M. and Eddy, S.R. 1997. Nucleic Acids Res. 25:955-964, PubMed 9023104).

transfer RNA-Asn (GTT) 23-1

transfer RNA-Ser (GCT) 2-1

transfer RNA-Gln (TTG) 9-1

transfer RNA-Glu (TTC) 9-1

transfer RNA isoleucine (anticodon AAU)

This record serves to anchor the annotations of this class of tRNAs at multiple locations on the human genome. The placements are predicted using tRNAscan-SE (Lowe, T.M. and Eddy, S.R. 1997. Nucleic Acids Res. 25:955-964, PubMed 9023104).

glycolipid transfer protein pseudogene 1

transfer RNA-Gln (TTG) 4-1

transfer RNA-Cys (GCA) 25-1

transfer RNA-Pro (CGG) 2-1

nuclear-encoded mitochondrial transfer RNA-Gln (CTG) 1-1

transfer RNA-Ser (GCT) 3-1

transfer RNA-Gly (GCC) 3-1

transfer RNA-Arg (CCT) 6-2

transfer RNA-Phe (GAA) 1-6

transfer RNA-Phe (GAA) 1-4

transfer RNA-Phe (GAA) 1-5

transfer RNA-Phe (GAA) 1-2

transfer RNA-Phe (GAA) 1-3

transfer RNA-Phe (GAA) 1-1

transfer RNA-Glu (CTC) 2-1

transfer RNA asparagine (anticodon GUU)

This record serves to anchor the annotations of this class of tRNAs at multiple locations on the human genome. The placements are predicted using tRNAscan-SE (Lowe, T.M. and Eddy, S.R. 1997. Nucleic Acids Res. 25:955-964, PubMed 9023104).

transfer RNA-Lys (CTT) 1-2

transfer RNA-Lys (CTT) 1-1

transfer RNA-Cys (GCA) 24-1

transfer RNA-Gly (GCC) 2-6

transfer RNA-Gly (GCC) 2-4

transfer RNA-Gly (GCC) 2-5

transfer RNA proline (anticodon AGG)

This record serves to anchor the annotations of this class of tRNAs at multiple locations on the human genome. The placements are predicted using tRNAscan-SE (Lowe, T.M. and Eddy, S.R. 1997. Nucleic Acids Res. 25:955-964, PubMed 9023104).

transfer RNA-Gln (TTG) 10-1

transfer RNA-Glu (CTC) 3-1

transfer RNA-Glu (CTC) 6-1

transfer RNA valine (anticodon AAC)

This record serves to anchor the annotations of this class of tRNAs at multiple locations on the human genome. The placements are predicted using tRNAscan-SE (Lowe, T.M. and Eddy, S.R. 1997. Nucleic Acids Res. 25:955-964, PubMed 9023104).

transfer RNA suppressor (CTA) 1-1

transfer RNA-Val (CAC) 11-1

transfer RNA-Ser (AGA) 4-1

transfer RNA-Glu (TTC) 8-1

nuclear-encoded mitochondrial transfer RNA-Gln (TTG) 4-1

transfer RNA-Cys (GCA) 3-1

transfer RNA serine (anticodon GCU)

This record serves to anchor the annotations of this class of tRNAs at multiple locations on the human genome. The placements are predicted using tRNAscan-SE (Lowe, T.M. and Eddy, S.R. 1997. Nucleic Acids Res. 25:955-964, PubMed 9023104).

nuclear-encoded mitochondrial transfer RNA-Gln (TTG) 5-1

transfer RNA tryptophan (anticodon CCA)

This record serves to anchor the annotations of this class of tRNAs at multiple locations on the human genome. The placements are predicted using tRNAscan-SE (Lowe, T.M. and Eddy, S.R. 1997. Nucleic Acids Res. 25:955-964, PubMed 9023104).

transfer RNA-iMet (CAT) 1-8

transfer RNA-iMet (CAT) 1-3

transfer RNA-iMet (CAT) 1-2

transfer RNA-iMet (CAT) 1-1

transfer RNA-iMet (CAT) 1-7

transfer RNA-iMet (CAT) 1-6

transfer RNA-iMet (CAT) 1-5

transfer RNA-iMet (CAT) 1-4

transfer RNA leucine (anticodon AAG)

This record serves to anchor the annotations of this class of tRNAs at multiple locations on the human genome. The placements are predicted using tRNAscan-SE (Lowe, T.M. and Eddy, S.R. 1997. Nucleic Acids Res. 25:955-964, PubMed 9023104).

transfer RNA threonine (anticodon UGU)

This record serves to anchor the annotations of this class of tRNAs at multiple locations on the human genome. The placements are predicted using tRNAscan-SE (Lowe, T.M. and Eddy, S.R. 1997. Nucleic Acids Res. 25:955-964, PubMed 9023104).

electron transfer flavoprotein regulatory factor 1

Involved in respiratory electron transport chain. Located in mitochondrion. [provided by Alliance of Genome Resources, Mar 2025]

bridge-like lipid transfer protein family member 2

This gene was initially characterized in human as having high expression levels in breast carcinomas and breast cancer cell lines. This gene also has increased expression in prostrate cancer cells relative to normal prostrate tissues. Expression of this gene is negatively regulated by direct binding of the microRNA miR-195 to its 3' UTR. miR-195 has been shown to modulate the invasiveness of prostrate cancer cells and xenograft metastases by downgrading expression of this gene. In mouse, the protein encoded by this gene was identified as an antigen on acute monocytic leukemia cells. In human, alternative splicing results in multiple transcript variants encoding distinct isoforms; some of these isoforms are predicted to contain an RNA pol II promoter FMP27 protein domain and a Golgi-body-localization APT1 domain. [provided by RefSeq, Apr 2017]

bridge-like lipid transfer protein family member 1

This gene is located on the long arm of chromosome 4 in a region that is associated with susceptibility to celiac disease. The encoded protein is similar to a Chinese hamster protein that is associated with spermatocyte and adipocyte differentiation. The C-terminus of the protein is also similar to a Caenorhabditis elegans protein that plays a role in lipid storage. In mammals, this protein is thought to function in the regulation of epithelial growth and differentiation, and in tumor development. [provided by RefSeq, Oct 2009]

bridge-like lipid transfer protein family member 3B

Enables GARP complex binding activity; lipid transfer activity; and protein homodimerization activity. Involved in early endosome to Golgi transport and intermembrane lipid transfer. Located in cytosol and early endosome. [provided by Alliance of Genome Resources, Mar 2025]

electron transfer flavoprotein subunit beta lysine methyltransferase

Enables heat shock protein binding activity and protein-lysine N-methyltransferase activity. Involved in negative regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase. Located in mitochondrial matrix. Part of protein-containing complex. [provided by Alliance of Genome Resources, Mar 2025]

bridge-like lipid transfer protein family member 3A

Enables histone deacetylase binding activity and identical protein binding activity. Located in late endosome. [provided by Alliance of Genome Resources, Mar 2025]

apolipoprotein lipid transfer particle homolog