Name

TLR1 Gene

toll-like receptor 1

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is ubiquitously expressed, and at higher levels than other TLR genes. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for this gene. [provided by RefSeq, Jul 2008]

tlr1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term tlr1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

TLR1 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for TLR1 from the Pathway Commons Protein-Protein Interactions dataset.

TLR1 Gene Set

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the TLR1 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

toll-like receptor tlr1:tlr2 signaling pathway Gene Set

From GO Biological Process Annotations 2015

genes participating in the toll-like receptor tlr1:tlr2 signaling pathway biological process from the curated GO Biological Process Annotations 2015 dataset.

Toll Like Receptor TLR1:TLR2 Cascade Gene Set

From Reactome Pathways 2014

proteins participating in the Toll Like Receptor TLR1:TLR2 Cascade pathway from the Reactome Pathways dataset.

toll-like receptor TLR1:TLR2 signaling pathway Gene Set

From GO Biological Process Annotations 2023

genes participating in the toll-like receptor TLR1:TLR2 signaling pathway biological process from the curated GO Biological Process Annotations 2023 dataset.

Toll Like Receptor TLR1:TLR2 Cascade Gene Set

From Reactome Pathways 2024

proteins participating in the Toll Like Receptor TLR1:TLR2 Cascade pathway from the Reactome Pathways 2024 dataset.

toll-like receptor TLR1:TLR2 signaling pathway Gene Set

From GO Biological Process Annotations 2025

genes participating in the toll-like receptor TLR1:TLR2 signaling pathway biological process from the curated GO Biological Process Annotations 2025 dataset.