TLR7

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Results for "TLR7": 1 gene, 16 gene sets

Name
TLR7 Gene toll-like receptor 7 The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. The human TLR family comprises 11 members. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. For the recognition of structural components in foreign microorganisms, the various TLRs exhibit different patterns of expression as well; in this way for example, TLR-3, -7, and -8 are essential in the recognition of single-stranded RNA viruses. TLR7 senses single-stranded RNA oligonucleotides containing guanosine- and uridine-rich sequences from RNA viruses, a recognition occuring in the endosomes of plasmacytoid dendritic cells and B cells. This gene is predominantly expressed in lung, placenta, and spleen, and is phylogenetically related and lies in close proximity to another family member, TLR8, on chromosome X. [provided by RefSeq, Aug 2020]
tlr7 Gene Set From GeneRIF Biological Term Annotations genes co-occuring with the biological term tlr7 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
TLR7 Gene Set From Pathway Commons Protein-Protein Interactions interacting proteins for TLR7 from the Pathway Commons Protein-Protein Interactions dataset.
TLR7 Gene Set From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures genes differentially expressed following the TLR7 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
TLR7 Gene Set From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas genes differentially expressed following the TLR7 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Gene Set From Reactome Pathways 2014 proteins participating in the TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway from the Reactome Pathways dataset.
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling Gene Set From Reactome Pathways 2014 proteins participating in the TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling pathway from the Reactome Pathways dataset.
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation Gene Set From Reactome Pathways 2014 proteins participating in the IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation pathway from the Reactome Pathways dataset.
Toll Like Receptor 7/8 (TLR7/8) Cascade Gene Set From Reactome Pathways 2014 proteins participating in the Toll Like Receptor 7/8 (TLR7/8) Cascade pathway from the Reactome Pathways dataset.
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation Gene Set From Reactome Pathways 2014 proteins participating in the IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation pathway from the Reactome Pathways dataset.
Defective regulation of TLR7 by endogenous ligand Gene Set From Reactome Pathways 2024 proteins participating in the Defective regulation of TLR7 by endogenous ligand pathway from the Reactome Pathways 2024 dataset.
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation Gene Set From Reactome Pathways 2024 proteins participating in the IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation pathway from the Reactome Pathways 2024 dataset.
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation Gene Set From Reactome Pathways 2024 proteins participating in the IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation pathway from the Reactome Pathways 2024 dataset.
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling Gene Set From Reactome Pathways 2024 proteins participating in the TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling pathway from the Reactome Pathways 2024 dataset.
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Gene Set From Reactome Pathways 2024 proteins participating in the TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway from the Reactome Pathways 2024 dataset.
Toll Like Receptor 7/8 (TLR7/8) Cascade Gene Set From Reactome Pathways 2024 proteins participating in the Toll Like Receptor 7/8 (TLR7/8) Cascade pathway from the Reactome Pathways 2024 dataset.
TLR7 AGONIST 852A Gene Set From DGIdb Drug Targets 2026 interacting proteins for the TLR7 AGONIST 852A drug from theDGIdb Drug Targets 2026 dataset.