Harmonizome 3.0

BRCA1 associated RING domain 1

This gene encodes a protein which interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, it shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and dominant protooncogenes. This protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. This protein may be the target of oncogenic mutations in breast or ovarian cancer. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

From NURSA Protein Complexes

proteins in the a-BARD1 (BARD1) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From COMPARTMENTS Curated Protein Localization Evidence Scores

proteins localized to the brca1-bard1 complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the brca1-bard1 complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

From CORUM Protein Complexes

proteins in the BRCA1-BARD1-BACH1-DNA damage complex II protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the P53-BARD1-Ku70 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the BRCA1-BARD1-BRCA2-DNA damage complex III protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the BARD1-BRCA1-CSTF complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the BRCA1-BARD1-BACH1-DNA damage complex I protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the BRCA1-BARD1-POLR2A complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the BARD1-BRCA1-CSTF64 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the BRCA1-BARD1-UbcH5c complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the BRCA1-BARD1-UbcH7c complex protein complex from the CORUM Protein Complexes dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term bard1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From GO Cellular Component Annotations 2015

proteins localized to the brca1-bard1 complex cellular component from the curated GO Cellular Component Annotations 2015 dataset.

From NURSA Protein-Protein Interactions

interacting proteins for BARD1 from the NURSA Protein-Protein Interactions dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for BARD1 from the Pathway Commons Protein-Protein Interactions dataset.

From PID Pathways

proteins participating in the BARD1 signaling events pathway from the PID Pathways dataset.

From GO Cellular Component Annotations 2023

proteins localized to the BRCA1-BARD1 complex cellular component from the curated GO Cellular Component Annotations 2023 dataset.

From Reactome Pathways 2024

proteins participating in the Defective DNA double strand break response due to BARD1 loss of function pathway from the Reactome Pathways 2024 dataset.

From GO Cellular Component Annotations 2025

proteins localized to the BRCA1-BARD1 complex cellular component from the curated GO Cellular Component Annotations 2025 dataset.

From COMPARTMENTS Curated Protein Localization Evidence Scores 2025

proteins localized to the BRCA1-BARD1 complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.

From COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025

proteins co-occuring with the BRCA1-BARD1 complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.

From ClinVar Gene-Phenotype Associations 2025

genes associated with the BARD1-related cancer predisposition phenotype from the curated ClinVar Gene-Phenotype Associations 2025 dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the BARD1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.