Harmonizome 3.0

mutS homolog 3

The protein encoded by this gene forms a heterodimer with MSH2 to form MutS beta, part of the post-replicative DNA mismatch repair system. MutS beta initiates mismatch repair by binding to a mismatch and then forming a complex with MutL alpha heterodimer. This gene contains a polymorphic 9 bp tandem repeat sequence in the first exon. The repeat is present 6 times in the reference genome sequence and 3-7 repeats have been reported. Defects in this gene are a cause of susceptibility to endometrial cancer. [provided by RefSeq, Mar 2011]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term msh3 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From MSigDB Cancer Gene Co-expression Modules

co-expressed genes for MSH3 from the MSigDB Cancer Gene Co-expression Modules dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for MSH3 from the Pathway Commons Protein-Protein Interactions dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the MSH3 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From CORUM Protein Complexes

proteins in the MSH2-MSH3 complex protein complex from the CORUM Protein Complexes dataset.

From Reactome Pathways 2014

proteins participating in the Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) pathway from the Reactome Pathways dataset.

From Reactome Pathways 2024

proteins participating in the Defective Mismatch Repair Associated With MSH3 pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) pathway from the Reactome Pathways 2024 dataset.