Harmonizome 3.0

activating transcription factor 6

This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis. [provided by RefSeq, Aug 2011]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term atf6 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From MotifMap Predicted Transcription Factor Targets

target genes of the ATF6 transcription factor predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for ATF6 from the Pathway Commons Protein-Protein Interactions dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the ATF6 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From JASPAR Predicted Human Transcription Factor Targets 2025

target genes of the ATF6 transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the ATF6 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From Reactome Pathways 2024

proteins participating in the ATF6 (ATF6-alpha) activates chaperone genes pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the ATF6 (ATF6-alpha) activates chaperones pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2014

proteins participating in the ATF6-alpha activates chaperone genes pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the ATF6-alpha activates chaperones pathway from the Reactome Pathways dataset.

From GO Biological Process Annotations 2023

genes participating in the ATF6-mediated unfolded protein response biological process from the curated GO Biological Process Annotations 2023 dataset.

From GO Biological Process Annotations 2023

genes participating in the negative regulation of ATF6-mediated unfolded protein response biological process from the curated GO Biological Process Annotations 2023 dataset.

From GO Biological Process Annotations 2023

genes participating in the regulation of ATF6-mediated unfolded protein response biological process from the curated GO Biological Process Annotations 2023 dataset.

From GO Biological Process Annotations 2023

genes participating in the positive regulation of ATF6-mediated unfolded protein response biological process from the curated GO Biological Process Annotations 2023 dataset.

From Reactome Pathways 2024

proteins participating in the ATF6B (ATF6-beta) activates chaperones pathway from the Reactome Pathways 2024 dataset.

From GO Biological Process Annotations 2025

genes participating in the ATF6-mediated unfolded protein response biological process from the curated GO Biological Process Annotations 2025 dataset.

From GO Biological Process Annotations 2025

genes participating in the negative regulation of ATF6-mediated unfolded protein response biological process from the curated GO Biological Process Annotations 2025 dataset.

From GO Biological Process Annotations 2025

genes participating in the regulation of ATF6-mediated unfolded protein response biological process from the curated GO Biological Process Annotations 2025 dataset.

From GO Biological Process Annotations 2025

genes participating in the positive regulation of ATF6-mediated unfolded protein response biological process from the curated GO Biological Process Annotations 2025 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC9882204-media-5.xlsx-ATF6-ATF6_Target_geneset_ATF6 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC8567035-CTM2-11-e578-s001.xlsx-ATF6-SEC61A1_ATF6 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.