Harmonizome 3.0

cadherin 1, type 1, E-cadherin (epithelial)

This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16. [provided by RefSeq, Nov 2015]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdh1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Hub Proteins Protein-Protein Interactions

interacting proteins for hub protein CDH1 from the curated Hub Proteins Protein-Protein Interactions dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for CDH1 from the Pathway Commons Protein-Protein Interactions dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the CDH1 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the CDH1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From Reactome Pathways 2014

proteins participating in the Autodegradation of Cdh1 by Cdh1:APC/C pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 pathway from the Reactome Pathways dataset.

From Reactome Pathways 2024

proteins participating in the APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Autodegradation of Cdh1 by Cdh1:APC/C pathway from the Reactome Pathways 2024 dataset.

From CORUM Protein Complexes

proteins in the CDH1-CKS1B complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Polycystin-1 multiprotein complex (ACTN1, CDH1, SRC, JUP, VCL, CTNNB1, PXN, BCAR1, PKD1, PTK2, TLN1) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the SMAD3-HEF1-APC10-CDH1 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the ITGAE-ITGB7-CDH1 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the CDH1-SKP2 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Cell-cell junction complex (CDH1-CTNNB1) protein complex from the CORUM Protein Complexes dataset.

From Reactome Pathways 2014

proteins participating in the Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase pathway from the Reactome Pathways dataset.

From Reactome Pathways 2024

proteins participating in the Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase pathway from the Reactome Pathways 2024 dataset.

From ClinVar Gene-Phenotype Associations 2025

genes associated with the CDH1-related diffuse gastric and lobular breast cancer syndrome phenotype from the curated ClinVar Gene-Phenotype Associations 2025 dataset.