Harmonizome 3.0

cyclin-dependent kinase 9

The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and known as important cell cycle regulators. This kinase was found to be a component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this protein and cyclin T, which suggested a possible involvement of this protein in AIDS. [provided by RefSeq, Jul 2008]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdk9 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From KEA Substrates of Kinases

substrates of the kinase CDK9 from the curated KEA Substrates of Kinases dataset.

From NURSA Protein-Protein Interactions

interacting proteins for CDK9 from the NURSA Protein-Protein Interactions dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for CDK9 from the Pathway Commons Protein-Protein Interactions dataset.

From PhosphoSitePlus Substrates of Kinases

substrates of the kinase CDK9 from the curated PhosphoSitePlus Substrates of Kinases dataset.

From Kinase Library Serine Threonine Kinome Atlas

substrates of the kinase CDK9 from the Kinase Library Serine Threonine Kinome Atlas dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the CDK9 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the CDK9 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From CORUM Protein Complexes

proteins in the POLR2A-CCNT1-CDK9-NCL-LEM6-CPSF2 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Heterotrimeric complex (CCNT1, CDK9, GRN) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Heterodimer complex (CDK9, IL6ST) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Transcription elongation factor complex (SUPT5H, CDK9, CCNT1) protein complex from the CORUM Protein Complexes dataset.

From DGIdb Drug Targets 2026

interacting proteins for the CDK9 INHIBITOR 1-7A-B1 drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the CDK9 PROTAC C3 drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the CDK9 INHIBITOR PRT2527 drug from theDGIdb Drug Targets 2026 dataset.