Harmonizome 3.0

cytochrome P450, family 2, subfamily E, polypeptide 1

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer. [provided by RefSeq, Jul 2008]

From Reactome Pathways 2014

proteins participating in the CYP2E1 reactions pathway from the Reactome Pathways dataset.

From Reactome Pathways 2024

proteins participating in the CYP2E1 reactions pathway from the Reactome Pathways 2024 dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cyp2e1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for CYP2E1 from the Pathway Commons Protein-Protein Interactions dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the CYP2E1 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From WikiPathways Pathways 2024

proteins participating in the Ethanol metabolism production of ROS by CYP2E1 pathway from the WikiPathways Pathways 2024 dataset.

From CTD Gene-Disease Associations

genes/proteins associated with the disease Drug-Related Side Effects and Adverse Reactions from the curated CTD Gene-Disease Associations dataset.

From GAD Gene-Disease Associations

genes associated with the disease antipsychotic-induced adverse reactions in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

From GAD Gene-Disease Associations

genes associated with the disease antibiotic-induced cutaneous allergic reactions in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

From GAD Gene-Disease Associations

genes associated with the disease morphine-induced adverse drug reactions in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

From GAD Gene-Disease Associations

genes associated with the disease cutaneous reactions to sulfonamides in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term reactions in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From GO Biological Process Annotations 2015

genes participating in the rna splicing, via transesterification reactions biological process from the curated GO Biological Process Annotations 2015 dataset.

From GO Biological Process Annotations 2015

genes participating in the rna splicing, via transesterification reactions with bulged adenosine as nucleophile biological process from the curated GO Biological Process Annotations 2015 dataset.

From HumanCyc Pathways

proteins participating in the glutathione redox reactions I pathway from the HumanCyc Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Amine Oxidase reactions pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Pyrimidine salvage reactions pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the COX reactions pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Reactions specific to the complex N-glycan synthesis pathway pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Reactions specific to the hybrid N-glycan synthesis pathway pathway from the Reactome Pathways dataset.

From DisGeNET Gene-Disease Associations

genes associated with the disease Other Acute Reactions To Stress in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

From DisGeNET Gene-Phenotype Associations

genes associated with the phenotype Severe Cutaneous Adverse Reactions (Smq) in GWAS and other genetic association datasets from the DisGeNET Gene-Phenotype Associations dataset.

From GO Biological Process Annotations 2023

genes participating in the RNA splicing, via transesterification reactions biological process from the curated GO Biological Process Annotations 2023 dataset.

From GO Biological Process Annotations 2023

genes participating in the RNA splicing, via transesterification reactions with bulged adenosine as nucleophile biological process from the curated GO Biological Process Annotations 2023 dataset.

From Reactome Pathways 2024

proteins participating in the Amine Oxidase reactions pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the COX reactions pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Reactions specific to the complex N-glycan synthesis pathway pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Reactions specific to the hybrid N-glycan synthesis pathway pathway from the Reactome Pathways 2024 dataset.

From GO Biological Process Annotations 2025

genes participating in the RNA splicing, via transesterification reactions biological process from the curated GO Biological Process Annotations 2025 dataset.

From GO Biological Process Annotations 2025

genes participating in the RNA splicing, via transesterification reactions with bulged adenosine as nucleophile biological process from the curated GO Biological Process Annotations 2025 dataset.