Harmonizome 3.0

interleukin 2

This gene is a member of the interleukin 2 (IL2) cytokine subfamily which includes IL4, IL7, IL9, IL15, IL21, erythropoietin, and thrombopoietin. The protein encoded by this gene is a secreted cytokine produced by activated CD4+ and CD8+ T lymphocytes, that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine (IL2R) is a heterotrimeric protein complex whose gamma chain is also shared by IL4 and IL7. The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Sep 2020]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for IL2 from the Pathway Commons Protein-Protein Interactions dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the IL2 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From CORUM Protein Complexes

proteins in the IL2-IL2RA-IL2RB complex protein complex from the CORUM Protein Complexes dataset.

From GEO Signatures of Differentially Expressed Genes for Gene Perturbations

genes differentially expressed following the SYNCRIP_OE_GDS1806_82_human_T-lymphocytes from normal donors were activated with anti-CD3 and IL2 gene perturbation from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

From OMIM Gene-Disease Associations

genes associated with the severe combined immunodeficiency due to il2 deficiency phenotype from the curated OMIM Gene-Disease Associations dataset.

From PID Pathways

proteins participating in the IL2-mediated signaling events pathway from the PID Pathways dataset.

From PID Pathways

proteins participating in the IL2 signaling events mediated by STAT5 pathway from the PID Pathways dataset.

From PID Pathways

proteins participating in the IL2 signaling events mediated by PI3K pathway from the PID Pathways dataset.

From WikiPathways Pathways 2024

proteins participating in the IL2 signaling pathway from the WikiPathways Pathways 2024 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the DI-LEU16-IL2 drug from theDGIdb Drug Targets 2026 dataset.