Harmonizome 3.0

notch 2

This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term notch2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for NOTCH2 from the Pathway Commons Protein-Protein Interactions dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the NOTCH2 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the NOTCH2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From CORUM Protein Complexes

proteins in the Notch2(N-TM)-Notch2(N-EC)-Delta complex protein complex from the CORUM Protein Complexes dataset.

From NURSA Protein Complexes

proteins in the BL8293 (NOTCH2) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From NURSA Protein Complexes

proteins in the BL8292 (NOTCH2) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From Reactome Pathways 2014

proteins participating in the NOTCH2 intracellular domain regulates transcription pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the NOTCH2 Activation and Transmission of Signal to the Nucleus pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Signaling by NOTCH2 pathway from the Reactome Pathways dataset.

From Reactome Pathways 2024

proteins participating in the NOTCH2 Activation and Transmission of Signal to the Nucleus pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the NOTCH2 intracellular domain regulates transcription pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Signaling by NOTCH2 pathway from the Reactome Pathways 2024 dataset.

From ClinVar Gene-Phenotype Associations 2025

genes associated with the Alagille syndrome due to a NOTCH2 point mutation phenotype from the curated ClinVar Gene-Phenotype Associations 2025 dataset.