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NOTCH3 Genenotch 3 This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). [provided by RefSeq, Jul 2008] |
notch3 Gene SetFrom GeneRIF Biological Term Annotations genes co-occuring with the biological term notch3 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. |
NOTCH3 Gene SetFrom Pathway Commons Protein-Protein Interactions interacting proteins for NOTCH3 from the Pathway Commons Protein-Protein Interactions dataset. |
NOTCH3 Gene SetFrom CM4AI KOLF21J CRISPRi Gene Perturbation Atlas genes differentially expressed following the NOTCH3 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas. |
MAML2-RBP-Jkappa-Notch3 complex Gene Setproteins in the MAML2-RBP-Jkappa-Notch3 complex protein complex from the CORUM Protein Complexes dataset. |
MAML3-RBP-Jkappa-Notch3 complex Gene Setproteins in the MAML3-RBP-Jkappa-Notch3 complex protein complex from the CORUM Protein Complexes dataset. |
Signaling by NOTCH3 Gene Setproteins participating in the Signaling by NOTCH3 pathway from the Reactome Pathways dataset. |
Apoptosis-related network due to altered Notch3 in ovarian cancer(Homo sapiens) Gene SetFrom WikiPathways Pathways 2014 proteins participating in the Apoptosis-related network due to altered Notch3 in ovarian cancer(Homo sapiens) pathway from the WikiPathways Pathways 2014 dataset. |
Apoptosis related network due to altered Notch3 in ovarian cancer Gene SetFrom WikiPathways Pathways 2024 proteins participating in the Apoptosis related network due to altered Notch3 in ovarian cancer pathway from the WikiPathways Pathways 2024 dataset. |
NOTCH3 Activation and Transmission of Signal to the Nucleus Gene Setproteins participating in the NOTCH3 Activation and Transmission of Signal to the Nucleus pathway from the Reactome Pathways 2024 dataset. |
NOTCH3 Intracellular Domain Regulates Transcription Gene Setproteins participating in the NOTCH3 Intracellular Domain Regulates Transcription pathway from the Reactome Pathways 2024 dataset. |
Noncanonical activation of NOTCH3 Gene Setproteins participating in the Noncanonical activation of NOTCH3 pathway from the Reactome Pathways 2024 dataset. |
Signaling by NOTCH3 Gene Setproteins participating in the Signaling by NOTCH3 pathway from the Reactome Pathways 2024 dataset. |