Harmonizome 3.0

retinoid X receptor, alpha

Retinoid X receptors (RXRs) and retinoic acid receptors (RARs) are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. These receptors function as transcription factors by binding as homodimers or heterodimers to specific sequences in the promoters of target genes. The protein encoded by this gene is a member of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014]

nuclear receptor subfamily 1, group H, member 2

The liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009 [PubMed 19436111]).[supplied by OMIM, Jan 2010]

From MotifMap Predicted Transcription Factor Targets

target genes of the NR1H2::RXRA transcription factor predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.

From JASPAR Predicted Human Transcription Factor Targets 2025

target genes of the NR1H2::RXRA transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term nr1h2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for NR1H2 from the Pathway Commons Protein-Protein Interactions dataset.

From Reactome Pathways 2024

proteins participating in the NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the NR1H2 & NR1H3 regulate gene expression linked to lipogenesis pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the NR1H2 and NR1H3-mediated signaling pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux pathway from the Reactome Pathways 2024 dataset.

From JASPAR Predicted Mouse Transcription Factor Targets 2025

target genes of the Nr1h2 transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2925 dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the NR1H2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From CORUM Protein Complexes

proteins in the CBP-RARA-RXRA-DNA complex, ligand stimulated protein complex from the CORUM Protein Complexes dataset.

From ENCODE Transcription Factor Targets

target genes of the RXRA transcription factor in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term rxra in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From MotifMap Predicted Transcription Factor Targets

target genes of the RXRA::VDR transcription factor predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for RXRA from the Pathway Commons Protein-Protein Interactions dataset.

From ChEA Transcription Factor Targets 2022

target genes of the RXRA-24833708-LIVER-MOUSE transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the RXRA gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From JASPAR Predicted Human Transcription Factor Targets 2025

target genes of the NR1H4::RXRA transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.

From JASPAR Predicted Human Transcription Factor Targets 2025

target genes of the NR4A2::RXRA transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.

From JASPAR Predicted Human Transcription Factor Targets 2025

target genes of the PPARA::RXRA transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.

From JASPAR Predicted Human Transcription Factor Targets 2025

target genes of the RARA::RXRA transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.

From JASPAR Predicted Human Transcription Factor Targets 2025

target genes of the RXRA::VDR transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.

From JASPAR Predicted Mouse Transcription Factor Targets 2025

target genes of the Nr1h3::Rxra transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2925 dataset.

From JASPAR Predicted Mouse Transcription Factor Targets 2025

target genes of the Pparg::Rxra transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2925 dataset.

From JASPAR Predicted Mouse Transcription Factor Targets 2025

target genes of the Rxra transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2925 dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the RXRA gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.