Harmonizome 3.0

intermediate filament family orphan 1

This gene is a member of the intermediate filament family. Intermediate filaments are proteins which are primordial components of the cytoskeleton and nuclear envelope. The proteins encoded by the members of this gene family are evolutionarily and structurally related but have limited sequence homology, with the exception of the central rod domain. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

intermediate filament family orphan 2

Predicted to be located in intermediate filament. [provided by Alliance of Genome Resources, Mar 2025]

phosphatase, orphan 2

Predicted to enable phosphatase activity. [provided by Alliance of Genome Resources, Mar 2025]

phosphatase, orphan 1

Enables phosphocholine phosphatase activity; phosphoethanolamine phosphatase activity; and pyrophosphatase activity. Predicted to be involved in bone mineralization involved in bone maturation. Predicted to act upstream of or within endochondral ossification. Predicted to be located in cytosol. Predicted to be active in extracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Mar 2025]

RAR-related orphan receptor C

The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known; however, studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role in thymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

RAR-related orphan receptor B

The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It is a DNA-binding protein that can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, and to help regulate the expression of some genes involved in circadian rhythm. [provided by RefSeq, Feb 2014]

RAR-related orphan receptor A

The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. Also, it has been shown to aid in the transcriptional regulation of some genes involved in circadian rhythm. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2014]

receptor tyrosine kinase-like orphan receptor 2

The protein encoded by this gene is a receptor protein tyrosine kinase and type I transmembrane protein that belongs to the ROR subfamily of cell surface receptors. The protein may be involved in the early formation of the chondrocytes and may be required for cartilage and growth plate development. Mutations in this gene can cause brachydactyly type B, a skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In addition, mutations in this gene can cause the autosomal recessive form of Robinow syndrome, which is characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly, and a dysmorphic facial appearance. [provided by RefSeq, Jul 2008]

receptor tyrosine kinase-like orphan receptor 1

This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2012]

phosphatase, orphan 1 pseudogene

RAD9-HUS1-RAD1 interacting nuclear orphan 1

Enables chromatin-protein adaptor activity. Involved in several processes, including DNA repair; cellular response to radiation; and regulation of cell cycle process. Located in chromosome and nucleus. Is active in chromatin and site of double-strand break. [provided by Alliance of Genome Resources, Mar 2025]

From Reactome Pathways 2014

proteins participating in the Orphan transporters pathway from the Reactome Pathways dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term orphan in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From GO Molecular Function Annotations 2015

genes performing the receptor tyrosine kinase-like orphan receptor binding molecular function from the curated GO Molecular Function Annotations 2015 dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the G protein-coupled receptor 4 orphan protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Orphan nuclear receptor, NURR type protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Orphan nuclear receptor, NOR1 type protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the GPCR, family 2, orphan receptor, GPR56 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the G protein-coupled receptor 3/6/12 orphan protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Rad9, Rad1, Hus1-interacting nuclear orphan protein 1 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Orphan nuclear receptor, HMR type protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Orphan nuclear receptor protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the G protein-coupled receptor 55 orphan protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the G protein-coupled receptor 37 orphan protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the G protein-coupled receptor 18 orphan protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the G10D orphan receptor protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the DEZ orphan receptor protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the G protein-coupled receptor 1 orphan protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Intermediate filament family orphan 1/2 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the G protein coupled receptor 152 orphan, predicted protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Sodium:neurotransmitter symporter, orphan protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From WikiPathways Pathways 2014

proteins participating in the Orphan GPCRs(Mus musculus) pathway from the WikiPathways Pathways 2014 dataset.

From GO Molecular Function Annotations 2023

genes performing the receptor tyrosine kinase-like orphan receptor binding molecular function from the curated GO Molecular Function Annotations 2023 dataset.

From GO Molecular Function Annotations 2025

genes performing the receptor tyrosine kinase-like orphan receptor binding molecular function from the curated GO Molecular Function Annotations 2025 dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term transporters in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the SLC41 divalent cation transporters, integral membrane domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From KEGG Pathways

proteins participating in the abc transporters general pathway from the KEGG Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Organic anion transporters pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Sodium-coupled sulphate, di- and tri-carboxylate transporters pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Na+/Cl- dependent neurotransmitter transporters pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Inositol transporters pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Na+-dependent glucose transporters pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Mitochondrial ABC transporters pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Metal ion SLC transporters pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the ABCA transporters in lipid homeostasis pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Amine compound SLC transporters pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Proton-coupled neutral amino acid transporters pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Facilitative Na+-independent glucose transporters pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Bicarbonate transporters pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Zinc transporters pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Bile salt and organic anion SLC transporters pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Amino acid and oligopeptide SLC transporters pathway from the Reactome Pathways dataset.

From WikiPathways Pathways 2024

proteins participating in the Fatty acid transporters pathway from the WikiPathways Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the ABC transporters in lipid homeostasis pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Bicarbonate transporters pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Disorders of transmembrane transporters pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Inositol transporters pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Metal ion SLC transporters pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Mitochondrial ABC transporters pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Na+/Cl- dependent neurotransmitter transporters pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Organic anion transporters pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Proton-coupled neutral amino acid transporters pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Sodium-coupled sulphate, di- and tri-carboxylate transporters pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Zinc transporters pathway from the Reactome Pathways 2024 dataset.

From KEGG Pathways 2026

proteins participating in the ABC transporters pathway from the KEGG Pathways 2026 dataset.