Harmonizome 3.0

v-rel avian reticuloendotheliosis viral oncogene homolog

This gene encodes a protein that belongs to the Rel homology domain/immunoglobulin-like fold, plexin, transcription factor (RHD/IPT) family. Members of this family regulate genes involved in apoptosis, inflammation, the immune response, and oncogenic processes. This proto-oncogene plays a role in the survival and proliferation of B lymphocytes. Mutation or amplification of this gene is associated with B-cell lymphomas, including Hodgkin's lymphoma. Single nucleotide polymorphisms in this gene are associated with susceptibility to ulcerative colitis and rheumatoid arthritis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]

v-rel avian reticuloendotheliosis viral oncogene homolog B

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and protein kinase binding activity. Involved in lymphocyte differentiation and negative regulation of interferon-beta production. Located in several cellular components, including centrosome; chromatin; and nucleoplasm. Part of nucleus and transcription repressor complex. Implicated in breast cancer and immunodeficiency 53. Biomarker of breast cancer and transitional cell carcinoma. [provided by Alliance of Genome Resources, Mar 2025]

v-rel avian reticuloendotheliosis viral oncogene homolog A

NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

v-rel avian reticuloendotheliosis viral oncogene homolog A pseudogene

From DGIdb Drug Targets 2026

interacting proteins for the REL-CISAPRIDE drug from theDGIdb Drug Targets 2026 dataset.

From CORUM Protein Complexes

proteins in the TNF-alpha/Nf-kappa B signaling complex (RPL6, RPL30, RPS13, CHUK, DDX3X, NFKB2, NFKBIB, REL, IKBKG, NFKB1, MAP3K8, RELB, GLG1, NFKBIA, RELA, TNIP2, GTF2I) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the CHUK-NFKB2-REL-IKBKG-SPAG9-NFKB1-NFKBIE-COPB2-TNIP1-NFKBIA-RELA-TNIP2 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the TNF-alpha/NF-kappa B signaling complex (SEC16A, CHUK, IKBKB, NFKB2, REL, IKBKG, MAP3K14, RELA, FBXW7, USP2) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the TNF-alpha/NF-kappa B signaling complex (CHUK, BTRC, NFKB2, PPP6C, REL, CUL1, IKBKE, SAPS2, SAPS1, ANKRD28, RELA, SKP1) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the REL-MAP3K8-RELA-TNIP2-PAPOLA complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the NFKB1-NFKB2-REL-RELA-RELB complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the TNF-alpha/NF-kappa B signaling complex (CHUK, KPNA3, NFKB2, NFKBIB, REL, IKBKG, NFKB1, NFKBIE, RELB, NFKBIA, RELA, TNIP2) protein complex from the CORUM Protein Complexes dataset.

From DrugBank Drug Targets

interacting proteins for the REL-(9R,12S)-9,10,11,12-TETRAHYDRO-9,12-EPOXY-1H-DIINDOLO[1,2,3-FG:3',2',1'-KL]PYRROLO[3,4-I][1,6]BENZODIAZOCINE-1,3(2H)-DIONE drug from the curated DrugBank Drug Targets dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term rel in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Rel homology domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From JASPAR Predicted Transcription Factor Targets

target genes of the REL transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.

From MotifMap Predicted Transcription Factor Targets

target genes of the REL transcription factor predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.

From MotifMap Predicted Transcription Factor Targets

target genes of the c-Rel transcription factor predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.

From NURSA Protein Complexes

proteins in the BL7055 (REL) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From NURSA Protein-Protein Interactions

interacting proteins for REL from the NURSA Protein-Protein Interactions dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for REL from the Pathway Commons Protein-Protein Interactions dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the REL gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From JASPAR Predicted Human Transcription Factor Targets 2025

target genes of the REL transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC11073972-41375_2024_2232_MOESM2_ESM.xlsx-REL-14_CD7_CD1a-_L-IC_DEG-DEG_L2FC_1_0_FDR_0_05_REL transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC11073972-41375_2024_2232_MOESM2_ESM.xlsx-REL-14_CD7_CD1a_DEG-DEG_L2FC_1_0_FDR_0_05_REL transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC11073972-41375_2024_2232_MOESM2_ESM.xlsx-REL-13_CD7_CD1a-_L-IC_DEG-DEG_L2FC_1_0_FDR_0_05_REL transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC11073972-41375_2024_2232_MOESM2_ESM.xlsx-REL-13_CD7_CD1a_DEG-DEG_L2FC_1_0_FDR_0_05_REL transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the REL gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.