TLR4

Filters:

Results for "TLR4": 1 gene, 13 gene sets

Name
TLR4 Gene toll-like receptor 4 The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. In silico studies have found a particularly strong binding of surface TLR4 with the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of Coronavirus disease-2019 (COVID-19). This receptor has also been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness, and with susceptibility to age-related macular degeneration. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2020]
tlr4 Gene Set From GeneRIF Biological Term Annotations genes co-occuring with the biological term tlr4 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
TLR4 Gene Set From Pathway Commons Protein-Protein Interactions interacting proteins for TLR4 from the Pathway Commons Protein-Protein Interactions dataset.
TLR4 Gene Set From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures genes differentially expressed following the TLR4 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
TICAM1-TICAM2-TLR4 complex Gene Set From CORUM Protein Complexes proteins in the TICAM1-TICAM2-TLR4 complex protein complex from the CORUM Protein Complexes dataset.
Activated TLR4 signalling Gene Set From Reactome Pathways 2014 proteins participating in the Activated TLR4 signalling pathway from the Reactome Pathways dataset.
Toll Like Receptor 4 (TLR4) Cascade Gene Set From Reactome Pathways 2014 proteins participating in the Toll Like Receptor 4 (TLR4) Cascade pathway from the Reactome Pathways dataset.
TRIF-mediated TLR3/TLR4 signaling Gene Set From Reactome Pathways 2014 proteins participating in the TRIF-mediated TLR3/TLR4 signaling pathway from the Reactome Pathways dataset.
TLR4 signaling and tolerance Gene Set From WikiPathways Pathways 2024 proteins participating in the TLR4 signaling and tolerance pathway from the WikiPathways Pathways 2024 dataset.
LDL influence on CD14 and TLR4 Gene Set From WikiPathways Pathways 2024 proteins participating in the LDL influence on CD14 and TLR4 pathway from the WikiPathways Pathways 2024 dataset.
MyD88-independent TLR4 cascade Gene Set From Reactome Pathways 2024 proteins participating in the MyD88-independent TLR4 cascade pathway from the Reactome Pathways 2024 dataset.
TRAF6-mediated induction of TAK1 complex within TLR4 complex Gene Set From Reactome Pathways 2024 proteins participating in the TRAF6-mediated induction of TAK1 complex within TLR4 complex pathway from the Reactome Pathways 2024 dataset.
TRIF (TICAM1)-mediated TLR4 signaling Gene Set From Reactome Pathways 2024 proteins participating in the TRIF (TICAM1)-mediated TLR4 signaling pathway from the Reactome Pathways 2024 dataset.
Toll Like Receptor 4 (TLR4) Cascade Gene Set From Reactome Pathways 2024 proteins participating in the Toll Like Receptor 4 (TLR4) Cascade pathway from the Reactome Pathways 2024 dataset.