Harmonizome 3.0

TNF receptor-associated factor 6, E3 ubiquitin protein ligase

The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from, members of the TNF receptor superfamily. This protein has an amino terminal RING domain which is followed by four zinc-finger motifs, a central coiled-coil region and a highly conserved carboxyl terminal domain, known as the TRAF-C domain and mediates signaling from members of the TNF receptor superfamily as well as the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. This protein also interacts with the transforming growth factor (TGF) beta receptor complex and is required for Smad-independent activation of the JNK and p38 kinases. The protein encoded by this gene is a key molecule in antiviral innate and antigen-specific immune responses. [provided by RefSeq, Nov 2021]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term traf6 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Hub Proteins Protein-Protein Interactions

interacting proteins for hub protein TRAF6 from the curated Hub Proteins Protein-Protein Interactions dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for TRAF6 from the Pathway Commons Protein-Protein Interactions dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the TRAF6 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the TRAF6 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From CORUM Protein Complexes

proteins in the TNFRSF11A-TRAF6-SRC complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Traf6-p62-aPKC complex, RANK-L stimulated protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Ecsit complex (ECSIT, MT-CO2, NDUFA1, MT-ND1, TRAF6, NDUFAF1) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the TRAF6-MALT1 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the TRAF6-TAK1 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Ask1-Traf6 complex, LPS induced protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Ubiquitin ligase complex (TRAF6, TAB2, MALT1, UEV1A, BCL10) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the TRAF6 oligomer complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Limd1-p62-Traf6-Prkcz complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Ecsit complex (ECSIT, MT-CO2, GAPDH, TRAF6, NDUFAF1) protein complex from the CORUM Protein Complexes dataset.

From Reactome Pathways 2014

proteins participating in the TRAF6 Mediated Induction of proinflammatory cytokines pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the TRAF6 mediated NF-kB activation pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the TRAF6 mediated IRF7 activation pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the TRAF6 mediated induction of TAK1 complex pathway from the Reactome Pathways dataset.

From Reactome Pathways 2024

proteins participating in the TICAM1,TRAF6-dependent induction of TAK1 complex pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the TRAF6 mediated IRF7 activation pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the TRAF6 mediated NF-kB activation pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the TRAF6-mediated induction of TAK1 complex within TLR4 complex pathway from the Reactome Pathways 2024 dataset.