| Name |
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ALK Geneanaplastic lymphoma receptor tyrosine kinase This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).[provided by RefSeq, Jan 2011] |
alk Gene SetFrom GeneRIF Biological Term Annotations genes co-occuring with the biological term alk in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. |
ALK Gene SetFrom KEA Substrates of Kinases substrates of the kinase ALK from the curated KEA Substrates of Kinases dataset. |
ALK Gene SetFrom Pathway Commons Protein-Protein Interactions interacting proteins for ALK from the Pathway Commons Protein-Protein Interactions dataset. |
ALK Gene SetFrom PhosphoSitePlus Substrates of Kinases substrates of the kinase ALK from the curated PhosphoSitePlus Substrates of Kinases dataset. |
ALK Gene SetFrom LINCS L1000 CMAP CRISPR Knockout Consensus Signatures genes differentially expressed following the ALK gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset. |
ALK Gene SetFrom Kinase Library Tyrosine Kinome Atlas substrates of the kinase ALK from the Kinase Library Tyrosine Kinome Atlas dataset. |
alk in cardiac myocytes Gene SetFrom Biocarta Pathways proteins participating in the alk in cardiac myocytes pathway from the Biocarta Pathways dataset. |
ALK tyrosine kinase receptor Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the ALK tyrosine kinase receptor protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
Nuclear-interacting partner of ALK/Rsm1-like Gene SetFrom InterPro Predicted Protein Domain Annotations proteins predicted to have the Nuclear-interacting partner of ALK/Rsm1-like protein domain from the InterPro Predicted Protein Domain Annotations dataset. |
Alk Positive Large B-Cell Lymphoma Gene SetFrom DisGeNET Gene-Disease Associations genes associated with the disease Alk Positive Large B-Cell Lymphoma in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. |
ALK mutants bind TKIs Gene Setproteins participating in the ALK mutants bind TKIs pathway from the Reactome Pathways 2024 dataset. |
ASP-3026-resistant ALK mutants Gene Setproteins participating in the ASP-3026-resistant ALK mutants pathway from the Reactome Pathways 2024 dataset. |
Drug resistance of ALK mutants Gene Setproteins participating in the Drug resistance of ALK mutants pathway from the Reactome Pathways 2024 dataset. |
MDK and PTN in ALK signaling Gene Setproteins participating in the MDK and PTN in ALK signaling pathway from the Reactome Pathways 2024 dataset. |
NVP-TAE684-resistant ALK mutants Gene Setproteins participating in the NVP-TAE684-resistant ALK mutants pathway from the Reactome Pathways 2024 dataset. |
Nuclear events stimulated by ALK signaling in cancer Gene Setproteins participating in the Nuclear events stimulated by ALK signaling in cancer pathway from the Reactome Pathways 2024 dataset. |
STAT3 nuclear events downstream of ALK signaling Gene Setproteins participating in the STAT3 nuclear events downstream of ALK signaling pathway from the Reactome Pathways 2024 dataset. |
Signaling by ALK Gene Setproteins participating in the Signaling by ALK pathway from the Reactome Pathways 2024 dataset. |
Signaling by ALK fusions and activated point mutants Gene Setproteins participating in the Signaling by ALK fusions and activated point mutants pathway from the Reactome Pathways 2024 dataset. |
Signaling by ALK in cancer Gene Setproteins participating in the Signaling by ALK in cancer pathway from the Reactome Pathways 2024 dataset. |
alectinib-resistant ALK mutants Gene Setproteins participating in the alectinib-resistant ALK mutants pathway from the Reactome Pathways 2024 dataset. |
brigatinib-resistant ALK mutants Gene Setproteins participating in the brigatinib-resistant ALK mutants pathway from the Reactome Pathways 2024 dataset. |
ceritinib-resistant ALK mutants Gene Setproteins participating in the ceritinib-resistant ALK mutants pathway from the Reactome Pathways 2024 dataset. |
crizotinib-resistant ALK mutants Gene Setproteins participating in the crizotinib-resistant ALK mutants pathway from the Reactome Pathways 2024 dataset. |
lorlatinib-resistant ALK mutants Gene Setproteins participating in the lorlatinib-resistant ALK mutants pathway from the Reactome Pathways 2024 dataset. |
ALK INHIBITOR ASP3026 Gene Setinteracting proteins for the ALK INHIBITOR ASP3026 drug from theDGIdb Drug Targets 2026 dataset. |
ALK INHIBITOR NVL-655 Gene Setinteracting proteins for the ALK INHIBITOR NVL-655 drug from theDGIdb Drug Targets 2026 dataset. |
ALK INHIBITOR TAE684 Gene Setinteracting proteins for the ALK INHIBITOR TAE684 drug from theDGIdb Drug Targets 2026 dataset. |
ALK/C-MET INHIBITOR TQ-B3139 Gene Setinteracting proteins for the ALK/C-MET INHIBITOR TQ-B3139 drug from theDGIdb Drug Targets 2026 dataset. |
