Harmonizome 3.0

aryl hydrocarbon receptor

The protein encoded by this gene is a ligand-activated helix-loop-helix transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450. Before ligand binding, the encoded protein is sequestered in the cytoplasm; upon ligand binding, this protein moves to the nucleus and stimulates transcription of target genes. [provided by RefSeq, Sep 2015]

aryl hydrocarbon receptor nuclear translocator

This gene encodes a protein containing a basic helix-loop-helix domain and two characteristic PAS domains along with a PAC domain. The encoded protein binds to ligand-bound aryl hydrocarbon receptor and aids in the movement of this complex to the nucleus, where it promotes the expression of genes involved in xenobiotic metabolism. This protein is also a co-factor for transcriptional regulation by hypoxia-inducible factor 1. Chromosomal translocation of this locus with the ETV6 (ets variant 6) gene on chromosome 12 have been described in leukemias. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013]

From MotifMap Predicted Transcription Factor Targets

target genes of the AhR:Arnt transcription factor predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.

From CORUM Protein Complexes

proteins in the Ubiquitin E3 ligase (AHR, ARNT, DDB1, TBL3, CUL4B, RBX1) protein complex from the CORUM Protein Complexes dataset.

From JASPAR Predicted Mouse Transcription Factor Targets 2025

target genes of the Ahr::Arnt transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2925 dataset.

From Biocarta Pathways

proteins participating in the ahr signal transduction pathway pathway from the Biocarta Pathways dataset.

From ChEA Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the AHR-22903824-MCF7-HUMAN transcription factor binding site profile from the CHEA Transcription Factor Binding Site Profiles dataset.

From ChEA Transcription Factor Targets

target genes of the AHR transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.

From CORUM Protein Complexes

proteins in the Aip-Hsp90-Ahr complex protein complex from the CORUM Protein Complexes dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ahr in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for AHR from the Pathway Commons Protein-Protein Interactions dataset.

From WikiPathways Pathways 2014

proteins participating in the Arylhydrocarbon receptor (AhR) signaling pathway(Homo sapiens) pathway from the WikiPathways Pathways 2014 dataset.

From ChEA Transcription Factor Targets 2022

target genes of the AHR-22903824-MCF-7-HUMAN transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the AHR gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC11551338-pnas.2411189121.sd01.xlsx-AHR-Unnamed_0_AHR transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the AHR gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From ChEA Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the ARNT-22903824-MCF7-HUMAN transcription factor binding site profile from the CHEA Transcription Factor Binding Site Profiles dataset.

From ChEA Transcription Factor Targets

target genes of the ARNT transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.

From CORUM Protein Complexes

proteins in the NEMO-HIF2(alpha)-ARNT complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Arnt-Sim2 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Arnt-Sim1 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the ARNT-HIF1A complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the ARNT-HLF complex protein complex from the CORUM Protein Complexes dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term arnt in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From JASPAR Predicted Transcription Factor Targets

target genes of the ARNT transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.

From MotifMap Predicted Transcription Factor Targets

target genes of the Arnt transcription factor predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.

From NURSA Protein-Protein Interactions

interacting proteins for ARNT from the NURSA Protein-Protein Interactions dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for ARNT from the Pathway Commons Protein-Protein Interactions dataset.

From ChEA Transcription Factor Targets 2022

target genes of the ARNT-22903824-MCF-7-HUMAN transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.

From JASPAR Predicted Human Transcription Factor Targets 2025

target genes of the ARNT::HIF1A transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.

From JASPAR Predicted Mouse Transcription Factor Targets 2025

target genes of the Arnt transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2925 dataset.

From JASPAR Predicted Mouse Transcription Factor Targets 2025

target genes of the Arnt::Hif1a transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2925 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC4141782-pone.0105522.s006.xls-ARNT-Unnamed_1_ARNT transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC6844300-koni-08-12-1665978.nxml--ARNT-Related_Genes_ARNT transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the ARNT gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.