BL8293 (NOTCH2)

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Results for "BL8293 (NOTCH2)": 3 genes, 14 gene sets

Name
NOTCH2 Gene notch 2 This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
MINAR1 Gene membrane integral NOTCH2 associated receptor 1 Involved in several processes, including negative regulation of TOR signaling; negative regulation of angiogenesis; and negative regulation of protein ubiquitination. Located in plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]
MINAR2 Gene membrane integral NOTCH2 associated receptor 2 Enables cholesterol binding activity. Involved in angiogenesis. Located in endoplasmic reticulum. Implicated in autosomal recessive nonsyndromic deafness. [provided by Alliance of Genome Resources, Mar 2025]
BL8293 (NOTCH2) Gene Set From NURSA Protein Complexes proteins in the BL8293 (NOTCH2) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.
Notch2(N-TM)-Notch2(N-EC)-Delta complex Gene Set From CORUM Protein Complexes proteins in the Notch2(N-TM)-Notch2(N-EC)-Delta complex protein complex from the CORUM Protein Complexes dataset.
notch2 Gene Set From GeneRIF Biological Term Annotations genes co-occuring with the biological term notch2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
BL8292 (NOTCH2) Gene Set From NURSA Protein Complexes proteins in the BL8292 (NOTCH2) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.
NOTCH2 Gene Set From Pathway Commons Protein-Protein Interactions interacting proteins for NOTCH2 from the Pathway Commons Protein-Protein Interactions dataset.
NOTCH2 intracellular domain regulates transcription Gene Set From Reactome Pathways 2014 proteins participating in the NOTCH2 intracellular domain regulates transcription pathway from the Reactome Pathways dataset.
NOTCH2 Activation and Transmission of Signal to the Nucleus Gene Set From Reactome Pathways 2014 proteins participating in the NOTCH2 Activation and Transmission of Signal to the Nucleus pathway from the Reactome Pathways dataset.
Signaling by NOTCH2 Gene Set From Reactome Pathways 2014 proteins participating in the Signaling by NOTCH2 pathway from the Reactome Pathways dataset.
NOTCH2 Gene Set From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures genes differentially expressed following the NOTCH2 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
NOTCH2 Activation and Transmission of Signal to the Nucleus Gene Set From Reactome Pathways 2024 proteins participating in the NOTCH2 Activation and Transmission of Signal to the Nucleus pathway from the Reactome Pathways 2024 dataset.
NOTCH2 intracellular domain regulates transcription Gene Set From Reactome Pathways 2024 proteins participating in the NOTCH2 intracellular domain regulates transcription pathway from the Reactome Pathways 2024 dataset.
Signaling by NOTCH2 Gene Set From Reactome Pathways 2024 proteins participating in the Signaling by NOTCH2 pathway from the Reactome Pathways 2024 dataset.
Alagille syndrome due to a NOTCH2 point mutation Gene Set From ClinVar Gene-Phenotype Associations 2025 genes associated with the Alagille syndrome due to a NOTCH2 point mutation phenotype from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
NOTCH2 Gene Set From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas genes differentially expressed following the NOTCH2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.