Harmonizome 3.0

polo-like kinase 1

The Ser/Thr protein kinase encoded by this gene belongs to the CDC5/Polo subfamily. It is highly expressed during mitosis and elevated levels are found in many different types of cancer. Depletion of this protein in cancer cells dramatically inhibited cell proliferation and induced apoptosis; hence, it is a target for cancer therapy. [provided by RefSeq, Sep 2015]

M-phase specific PLK1 interacting protein

The protein encoded by this gene localizes to the centrosome during mitosis and to the midbody during cytokinesis. The protein is phosphorylated by cyclin-dependent kinase 1 during mitosis and subsequently interacts with polo-like kinase 1. The protein is thought to function in regulating mitosis and cytokinesis. Mutations in this gene result in nonphotosensitive trichothiodystrophy. [provided by RefSeq, Nov 2009]

serine/threonine-protein kinase PLK1-like

From NURSA Protein Complexes

proteins in the BL977 (PLK1) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From DGIdb Drug Targets 2026

interacting proteins for the LIPID ENCAPSULATED ANTI-PLK1 SIRNA TKM-PLK1 drug from theDGIdb Drug Targets 2026 dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term plk1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Hub Proteins Protein-Protein Interactions

interacting proteins for hub protein PLK1 from the curated Hub Proteins Protein-Protein Interactions dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the M-phase-specific PLK1-interacting protein-like, vertebrate protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the M-phase-specific PLK1-interacting protein-like protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From KEA Substrates of Kinases

substrates of the kinase PLK1 from the curated KEA Substrates of Kinases dataset.

From NURSA Protein Complexes

proteins in the BL976 (PLK1) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From NURSA Protein Complexes

proteins in the BL978 (PLK1) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for PLK1 from the Pathway Commons Protein-Protein Interactions dataset.

From Phosphosite Textmining Biological Term Annotations

proteins co-occuring with the biological term plk1 in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.

From PhosphoSitePlus Substrates of Kinases

substrates of the kinase PLK1 from the curated PhosphoSitePlus Substrates of Kinases dataset.

From PID Pathways

proteins participating in the PLK1 signaling events pathway from the PID Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Regulation of PLK1 Activity at G2/M Transition pathway from the Reactome Pathways dataset.

From Kinase Library Serine Threonine Kinome Atlas

substrates of the kinase PLK1 from the Kinase Library Serine Threonine Kinome Atlas dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the PLK1 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From Reactome Pathways 2024

proteins participating in the Regulation of PLK1 Activity at G2/M Transition pathway from the Reactome Pathways 2024 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the DUAL BRD4/PLK1 INHIBITOR 23 drug from theDGIdb Drug Targets 2026 dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the PLK1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.