Harmonizome 3.0

erythropoietin

This gene encodes a secreted, glycosylated cytokine composed of four alpha helical bundles. The encoded protein is mainly synthesized in the kidney, secreted into the blood plasma, and binds to the erythropoietin receptor to promote red blood cell production, or erythropoiesis, in the bone marrow. Expression of this gene is upregulated under hypoxic conditions, in turn leading to increased erythropoiesis and enhanced oxygen-carrying capacity of the blood. Expression of this gene has also been observed in brain and in the eye, and elevated expression levels have been observed in diabetic retinopathy and ocular hypertension. Recombinant forms of the encoded protein exhibit neuroprotective activity against a variety of potential brain injuries, as well as antiapoptotic functions in several tissue types, and have been used in the treatment of anemia and to enhance the efficacy of cancer therapies. [provided by RefSeq, Aug 2017]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term epo in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Guide to Pharmacology Protein Ligands of Receptors

receptors of the EPO ligand (protein) from the curated Guide to Pharmacology Protein Ligands of Receptors dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for EPO from the Pathway Commons Protein-Protein Interactions dataset.

From Biocarta Pathways

proteins participating in the epo signaling pathway pathway from the Biocarta Pathways dataset.

From CORUM Protein Complexes

proteins in the Epo-R-PLC-gamma-TRPC2 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the EPO-EPOR complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Epo-R-IP(3)R type II-TRPC2 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Epo-R-PLC-gamma 1-IP(3)R type II-TRPC2 signaling complex protein complex from the CORUM Protein Complexes dataset.

From PID Pathways

proteins participating in the EPO signaling pathway pathway from the PID Pathways dataset.

From WikiPathways Pathways 2014

proteins participating in the EPO Receptor Signaling(Homo sapiens) pathway from the WikiPathways Pathways 2014 dataset.

From WikiPathways Pathways 2014

proteins participating in the EPO Receptor Signaling(Mus musculus) pathway from the WikiPathways Pathways 2014 dataset.

From WikiPathways Pathways 2024

proteins participating in the EPO receptor signaling pathway from the WikiPathways Pathways 2024 dataset.

From ClinVar Gene-Phenotype Associations 2025

genes associated with the Primary familial polycythemia due to EPO receptor mutation phenotype from the curated ClinVar Gene-Phenotype Associations 2025 dataset.