Harmonizome 3.0

Fas (TNFRSF6)-associated via death domain

The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term fadd in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the FADD protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From NURSA Protein-Protein Interactions

interacting proteins for FADD from the NURSA Protein-Protein Interactions dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for FADD from the Pathway Commons Protein-Protein Interactions dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the FADD gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the FADD gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From CORUM Protein Complexes

proteins in the FAS-FADD-CASP10 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Ternary complex (TRAF2, FADD, TRADD) protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Death induced signaling complex DISC (FAS, FADD, CASP8, CFLAR), membrane-associated, CD95L induced protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the FAS-FADD-CASP8-CASP10 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the FAS-FADD-CASP8 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the AK2-FADD-caspase-10 (AFAC10) complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Death induced signaling complex II (FADD, CASP8, CFLAR), cytosolic, CD95L induced protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the CASP8-FADD-MALT1-BCL10 complex protein complex from the CORUM Protein Complexes dataset.

From Reactome Pathways 2014

proteins participating in the NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 pathway from the Reactome Pathways dataset.

From Reactome Pathways 2024

proteins participating in the NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 pathway from the Reactome Pathways 2024 dataset.

From ClinVar Gene-Phenotype Associations 2025

genes associated with the FADD-related immunodeficiency phenotype from the curated ClinVar Gene-Phenotype Associations 2025 dataset.