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FGFR2 Genefibroblast growth factor receptor 2 The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009] |
fgfr2 Gene SetFrom GeneRIF Biological Term Annotations genes co-occuring with the biological term fgfr2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. |
FGFR2 Gene SetFrom KEA Substrates of Kinases substrates of the kinase FGFR2 from the curated KEA Substrates of Kinases dataset. |
FGFR2 Gene SetFrom Pathway Commons Protein-Protein Interactions interacting proteins for FGFR2 from the Pathway Commons Protein-Protein Interactions dataset. |
FGFR2 Gene SetFrom PhosphoSitePlus Substrates of Kinases substrates of the kinase FGFR2 from the curated PhosphoSitePlus Substrates of Kinases dataset. |
FGFR2 Gene SetFrom Kinase Library Tyrosine Kinome Atlas substrates of the kinase FGFR2 from the Kinase Library Tyrosine Kinome Atlas dataset. |
FGFR2 Gene SetFrom CM4AI KOLF21J CRISPRi Gene Perturbation Atlas genes differentially expressed following the FGFR2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas. |
FGFR2-c-Cbl-Lyn-Fyn complex Gene Setproteins in the FGFR2-c-Cbl-Lyn-Fyn complex protein complex from the CORUM Protein Complexes dataset. |
Signaling by FGFR2 amplification mutants Gene Setproteins participating in the Signaling by FGFR2 amplification mutants pathway from the Reactome Pathways dataset. |
Signaling by FGFR2 mutants Gene Setproteins participating in the Signaling by FGFR2 mutants pathway from the Reactome Pathways dataset. |
Activated point mutants of FGFR2 Gene Setproteins participating in the Activated point mutants of FGFR2 pathway from the Reactome Pathways dataset. |
FGFR2 ligand binding and activation Gene Setproteins participating in the FGFR2 ligand binding and activation pathway from the Reactome Pathways dataset. |
Activated point mutants of FGFR2 Gene Setproteins participating in the Activated point mutants of FGFR2 pathway from the Reactome Pathways 2024 dataset. |
Downstream signaling of activated FGFR2 Gene Setproteins participating in the Downstream signaling of activated FGFR2 pathway from the Reactome Pathways 2024 dataset. |
FGFR2 alternative splicing Gene Setproteins participating in the FGFR2 alternative splicing pathway from the Reactome Pathways 2024 dataset. |
FGFR2 ligand binding and activation Gene Setproteins participating in the FGFR2 ligand binding and activation pathway from the Reactome Pathways 2024 dataset. |
FGFR2 mutant receptor activation Gene Setproteins participating in the FGFR2 mutant receptor activation pathway from the Reactome Pathways 2024 dataset. |
FRS-mediated FGFR2 signaling Gene Setproteins participating in the FRS-mediated FGFR2 signaling pathway from the Reactome Pathways 2024 dataset. |
Negative regulation of FGFR2 signaling Gene Setproteins participating in the Negative regulation of FGFR2 signaling pathway from the Reactome Pathways 2024 dataset. |
PI-3K cascade:FGFR2 Gene Setproteins participating in the PI-3K cascade:FGFR2 pathway from the Reactome Pathways 2024 dataset. |
Phospholipase C-mediated cascade; FGFR2 Gene Setproteins participating in the Phospholipase C-mediated cascade; FGFR2 pathway from the Reactome Pathways 2024 dataset. |
SHC-mediated cascade:FGFR2 Gene Setproteins participating in the SHC-mediated cascade:FGFR2 pathway from the Reactome Pathways 2024 dataset. |
Signaling by FGFR2 Gene Setproteins participating in the Signaling by FGFR2 pathway from the Reactome Pathways 2024 dataset. |
Signaling by FGFR2 IIIa TM Gene Setproteins participating in the Signaling by FGFR2 IIIa TM pathway from the Reactome Pathways 2024 dataset. |
Signaling by FGFR2 amplification mutants Gene Setproteins participating in the Signaling by FGFR2 amplification mutants pathway from the Reactome Pathways 2024 dataset. |
Signaling by FGFR2 fusions Gene Setproteins participating in the Signaling by FGFR2 fusions pathway from the Reactome Pathways 2024 dataset. |
Signaling by FGFR2 in disease Gene Setproteins participating in the Signaling by FGFR2 in disease pathway from the Reactome Pathways 2024 dataset. |
FGFR2-related craniosynostosis Gene SetFrom ClinVar Gene-Phenotype Associations 2025 genes associated with the FGFR2-related craniosynostosis phenotype from the curated ClinVar Gene-Phenotype Associations 2025 dataset. |
FGFR2-related syndromic and non-syndromic craniosynostoses Gene SetFrom ClinVar Gene-Phenotype Associations 2025 genes associated with the FGFR2-related syndromic and non-syndromic craniosynostoses phenotype from the curated ClinVar Gene-Phenotype Associations 2025 dataset. |
FGFR2 INHIBITOR 3HP-2827 Gene Setinteracting proteins for the FGFR2 INHIBITOR 3HP-2827 drug from theDGIdb Drug Targets 2026 dataset. |
