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FGFR3 Genefibroblast growth factor receptor 3 This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. [provided by RefSeq, Aug 2017] |
fgfr3 Gene SetFrom GeneRIF Biological Term Annotations genes co-occuring with the biological term fgfr3 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. |
FGFR3 Gene SetFrom KEA Substrates of Kinases substrates of the kinase FGFR3 from the curated KEA Substrates of Kinases dataset. |
FGFR3 Gene SetFrom Pathway Commons Protein-Protein Interactions interacting proteins for FGFR3 from the Pathway Commons Protein-Protein Interactions dataset. |
FGFR3 Gene SetFrom PhosphoSitePlus Substrates of Kinases substrates of the kinase FGFR3 from the curated PhosphoSitePlus Substrates of Kinases dataset. |
FGFR3 Gene SetFrom LINCS L1000 CMAP CRISPR Knockout Consensus Signatures genes differentially expressed following the FGFR3 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset. |
FGFR3 Gene SetFrom Kinase Library Tyrosine Kinome Atlas substrates of the kinase FGFR3 from the Kinase Library Tyrosine Kinome Atlas dataset. |
FGFR3 Gene SetFrom CM4AI KOLF21J CRISPRi Gene Perturbation Atlas genes differentially expressed following the FGFR3 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas. |
Signaling by FGFR3 mutants Gene Setproteins participating in the Signaling by FGFR3 mutants pathway from the Reactome Pathways dataset. |
FGFR3 ligand binding and activation Gene Setproteins participating in the FGFR3 ligand binding and activation pathway from the Reactome Pathways dataset. |
t(4;14) translocations of FGFR3 Gene Setproteins participating in the t(4;14) translocations of FGFR3 pathway from the Reactome Pathways dataset. |
Signaling by activated point mutants of FGFR3 Gene Setproteins participating in the Signaling by activated point mutants of FGFR3 pathway from the Reactome Pathways dataset. |
Human - Motor Cortex - Cluster - FGFR3+ SERPINI2+ Layer 1 astrocyte Gene SetFrom HuBMAP Azimuth Cell Type Annotations genes associated with the Human - Motor Cortex - Cluster - FGFR3+ SERPINI2+ Layer 1 astrocyte cell type from the HuBMAP Azimuth Cell Type Annotations dataset. |
Human - Motor Cortex - Cluster - FGFR3+ AQP1+ Layer 1-6 astrocyte Gene SetFrom HuBMAP Azimuth Cell Type Annotations genes associated with the Human - Motor Cortex - Cluster - FGFR3+ AQP1+ Layer 1-6 astrocyte cell type from the HuBMAP Azimuth Cell Type Annotations dataset. |
Human - Motor Cortex - Cluster - FGFR3+ PLCG1+ Layer 1-6 astrocyte Gene SetFrom HuBMAP Azimuth Cell Type Annotations genes associated with the Human - Motor Cortex - Cluster - FGFR3+ PLCG1+ Layer 1-6 astrocyte cell type from the HuBMAP Azimuth Cell Type Annotations dataset. |
FGFR3 signaling in chondrocyte proliferation and terminal differentiation Gene SetFrom WikiPathways Pathways 2024 proteins participating in the FGFR3 signaling in chondrocyte proliferation and terminal differentiation pathway from the WikiPathways Pathways 2024 dataset. |
Perturb_6668_KO_FGFR1/FGFR3/FGFR4_SRP386785 Gene SetFrom PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations genes differentially expressed following the Perturb_6668_KO_FGFR1/FGFR3/FGFR4_SRP386785 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. |
Downstream signaling of activated FGFR3 Gene Setproteins participating in the Downstream signaling of activated FGFR3 pathway from the Reactome Pathways 2024 dataset. |
FGFR3 ligand binding and activation Gene Setproteins participating in the FGFR3 ligand binding and activation pathway from the Reactome Pathways 2024 dataset. |
FGFR3 mutant receptor activation Gene Setproteins participating in the FGFR3 mutant receptor activation pathway from the Reactome Pathways 2024 dataset. |
FRS-mediated FGFR3 signaling Gene Setproteins participating in the FRS-mediated FGFR3 signaling pathway from the Reactome Pathways 2024 dataset. |
Negative regulation of FGFR3 signaling Gene Setproteins participating in the Negative regulation of FGFR3 signaling pathway from the Reactome Pathways 2024 dataset. |
PI-3K cascade:FGFR3 Gene Setproteins participating in the PI-3K cascade:FGFR3 pathway from the Reactome Pathways 2024 dataset. |
Phospholipase C-mediated cascade; FGFR3 Gene Setproteins participating in the Phospholipase C-mediated cascade; FGFR3 pathway from the Reactome Pathways 2024 dataset. |
SHC-mediated cascade:FGFR3 Gene Setproteins participating in the SHC-mediated cascade:FGFR3 pathway from the Reactome Pathways 2024 dataset. |
Signaling by FGFR3 Gene Setproteins participating in the Signaling by FGFR3 pathway from the Reactome Pathways 2024 dataset. |
Signaling by FGFR3 fusions in cancer Gene Setproteins participating in the Signaling by FGFR3 fusions in cancer pathway from the Reactome Pathways 2024 dataset. |
Signaling by FGFR3 in disease Gene Setproteins participating in the Signaling by FGFR3 in disease pathway from the Reactome Pathways 2024 dataset. |
Signaling by activated point mutants of FGFR3 Gene Setproteins participating in the Signaling by activated point mutants of FGFR3 pathway from the Reactome Pathways 2024 dataset. |
t(4;14) translocations of FGFR3 Gene Setproteins participating in the t(4;14) translocations of FGFR3 pathway from the Reactome Pathways 2024 dataset. |
Brain_CT2_Astro L1-6 FGFR3 AQP1 Gene SetFrom HuBMAP ASCT+B Annotations biomarker genes for the Brain_CT2_Astro L1-6 FGFR3 AQP1 cell type from the HuBMAP ASCT+B dataset. |
Brain_CT2_Astro L1 FGFR3 SERPINI2 Gene SetFrom HuBMAP ASCT+B Annotations biomarker genes for the Brain_CT2_Astro L1 FGFR3 SERPINI2 cell type from the HuBMAP ASCT+B dataset. |
Brain_CT2_Astro L1-6 FGFR3 PLCG1 Gene SetFrom HuBMAP ASCT+B Annotations biomarker genes for the Brain_CT2_Astro L1-6 FGFR3 PLCG1 cell type from the HuBMAP ASCT+B dataset. |
Brain_CT2_Astro L1 FGFR3 SERPINI2 Gene SetFrom HuBMAP ASCT+B Augmented with RNA-seq Coexpression biomarker genes for the Brain_CT2_Astro L1 FGFR3 SERPINI2 cell type from the HuBMAP ASCT+B Augmented with RNA-seq Coexpression dataset. |
Brain_CT2_Astro L1-6 FGFR3 AQP1 Gene SetFrom HuBMAP ASCT+B Augmented with RNA-seq Coexpression biomarker genes for the Brain_CT2_Astro L1-6 FGFR3 AQP1 cell type from the HuBMAP ASCT+B Augmented with RNA-seq Coexpression dataset. |
Brain_CT2_Astro L1-6 FGFR3 PLCG1 Gene SetFrom HuBMAP ASCT+B Augmented with RNA-seq Coexpression biomarker genes for the Brain_CT2_Astro L1-6 FGFR3 PLCG1 cell type from the HuBMAP ASCT+B Augmented with RNA-seq Coexpression dataset. |
FGFR3-related chondrodysplasia Gene SetFrom ClinVar Gene-Phenotype Associations 2025 genes associated with the FGFR3-related chondrodysplasia phenotype from the curated ClinVar Gene-Phenotype Associations 2025 dataset. |
FGFR3-related CATSHL syndrome Gene SetFrom ClinVar Gene-Phenotype Associations 2025 genes associated with the FGFR3-related CATSHL syndrome phenotype from the curated ClinVar Gene-Phenotype Associations 2025 dataset. |
