Harmonizome 3.0

microRNA 218-1

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

transmembrane protein 218

Predicted to be located in cilium and membrane. Implicated in Joubert syndrome. [provided by Alliance of Genome Resources, Mar 2025]

family with sequence similarity 218, member A

microRNA 218-2

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

RNA, 5S ribosomal pseudogene 218

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the GR 218 231 ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From DGIdb Drug Targets 2026

interacting proteins for the GR 218,231 drug from theDGIdb Drug Targets 2026 dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the YM 218 ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Transmembrane protein 218 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From MiRTarBase microRNA Targets

target genes of the hsa-miR-218-5p microRNA in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset.

From MiRTarBase microRNA Targets

target genes of the hsa-miR-218-1-3p microRNA in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset.

From TargetScan Predicted Conserved microRNA Targets

target genes of the hsa-miR-218 microRNA predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset.

From TargetScan Predicted Nonconserved microRNA Targets

target genes of the hsa-miR-218 microRNA predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset.

From HuBMAP ASCT+B Annotations

biomarker genes for the Brain_CT2_MSN 218 cell type from the HuBMAP ASCT+B dataset.

From HuBMAP ASCT+B Augmented with RNA-seq Coexpression

biomarker genes for the Brain_CT2_MSN 218 cell type from the HuBMAP ASCT+B Augmented with RNA-seq Coexpression dataset.

From DGIdb Drug Targets 2026

interacting proteins for the YM 218 drug from theDGIdb Drug Targets 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC11665843-SYB2-18-218-s001.pdf-8-SP110_SP110 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC11665843-SYB2-18-218-s001.pdf-58-TCF7_TCF7 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC11665843-SYB2-18-218-s001.pdf-132-TCF12_TCF12 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC11665843-SYB2-18-218-s001.pdf-141-ZBTB10_ZBTB10 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC11665843-SYB2-18-218-s001.pdf-156-GTF2I_GTF2I transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC11665843-SYB2-18-218-s001.pdf-164-PBX1_PBX1 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC11665843-SYB2-18-218-s001.pdf-181-BATF_BATF transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC12356745-12015_2025_10896_MOESM2_ESM.pdf-218-LCOR_LCOR transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From ChEA Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the PPARD-23208498-MDA-MB-231-HUMAN transcription factor binding site profile from the CHEA Transcription Factor Binding Site Profiles dataset.

From COSMIC Cell Line Gene CNV Profiles

genes with high or low copy number in KARPAS-231 relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.

From COSMIC Cell Line Gene CNV Profiles

genes with high or low copy number in MDA-MB-231 relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.

From COSMIC Cell Line Gene Mutation Profiles

genes mutated in the KARPAS-231 cell line from the COSMIC Cell Line Gene Mutation Profiles dataset.

From COSMIC Cell Line Gene Mutation Profiles

genes mutated in the MDA-MB-231 cell line from the COSMIC Cell Line Gene Mutation Profiles dataset.

From DrugBank Drug Targets

interacting proteins for the GEM-231 drug from the curated DrugBank Drug Targets dataset.

From GDSC Cell Line Gene Expression Profiles

genes with high or low expression in MDA-MB-231 relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.

From GEO Signatures of Differentially Expressed Genes for Gene Perturbations

genes differentially expressed following the PIAS1_Depletion_GDS5076_12_human_MDA-MB 231 breast cancer cells gene perturbation from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

From GEO Signatures of Differentially Expressed Genes for Gene Perturbations

genes differentially expressed following the LOXL2_DEPLETION_GDS4884_88_human_MDA-MB-231 cells gene perturbation from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

From GEO Signatures of Differentially Expressed Genes for Gene Perturbations

genes differentially expressed following the ZNF217_OE_GDS4885_317_human_MDA-MB-231 breast cancer cells gene perturbation from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

From GEO Signatures of Differentially Expressed Genes for Gene Perturbations

genes differentially expressed following the PIN1_DEPLETION_GDS4070_450_human_MDA-MB-231 breast cancer cells gene perturbation from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

From GEO Signatures of Differentially Expressed Genes for Gene Perturbations

genes differentially expressed following the PTHrP_KD_GDS1664_438_human_MDA-MB-231 gene perturbation from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

From GEO Signatures of Differentially Expressed Genes for Gene Perturbations

genes differentially expressed following the PTHrP_KD_GDS1664_71_human_MDA-MB-231 breast cancer cells gene perturbation from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

From GEO Signatures of Differentially Expressed Genes for Gene Perturbations

genes differentially expressed following the TP53_DEPLETION_GDS4070_451_human_MDA-MB-231 breast cancer cells (depleted of MUTANT-p53) gene perturbation from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

From GEO Signatures of Differentially Expressed Genes for Gene Perturbations

genes differentially expressed following the RhoGDIbeta_KD_GDS2864_634_human_MDA-MB-231 breast cancer cells gene perturbation from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

From GEO Signatures of Differentially Expressed Genes for Gene Perturbations

genes differentially expressed following the LOXL2_KD_GSE35600_688_human_MDA-MB-231 cells gene perturbation from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

From GEO Signatures of Differentially Expressed Genes for Gene Perturbations

genes differentially expressed following the c-MYC_KD_GDS2526_113_human_MDA-MB-231 BREAST CANCER cell line gene perturbation from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the calhex 231 ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the NVP 231 ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Transmembrane protein 231 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles

genes with high or low copy number in MDA-MB-231 relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.

From Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles

genes with high or low expression in MDA-MB-231 relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset.

From Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles

genes mutated in the MDA-MB-231 cell line from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset.

From TISSUES Text-mining Tissue Protein Expression Evidence Scores

proteins co-occuring with the tissue wehi-231 cell in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.

From TISSUES Text-mining Tissue Protein Expression Evidence Scores

proteins co-occuring with the tissue mda-mb-231 cell in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.

From Sanger Dependency Map Cancer Cell Line Proteomics

proteins associated with the cell line KARPAS-231 from the Sanger Dependency Map Cancer Cell Line Proteomics dataset.

From Sanger Dependency Map Cancer Cell Line Proteomics

proteins associated with the cell line MDA-MB-231 from the Sanger Dependency Map Cancer Cell Line Proteomics dataset.

From ChEA Transcription Factor Targets 2022

target genes of the PPARD-23208498-MDA-MB-231-HUMAN transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.

From ChEA Transcription Factor Targets 2022

target genes of the DACH1-20351289-MDA-MB-231-HUMAN transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.

From HuBMAP ASCT+B Annotations

biomarker genes for the Brain_CT2_EMSN 231 cell type from the HuBMAP ASCT+B dataset.

From HuBMAP ASCT+B Augmented with RNA-seq Coexpression

biomarker genes for the Brain_CT2_EMSN 231 cell type from the HuBMAP ASCT+B Augmented with RNA-seq Coexpression dataset.

From TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025

proteins co-occuring with the tissue MDA-MB-231 cell in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset.

From TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025

proteins co-occuring with the tissue WEHI-231 cell in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset.

From TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025

proteins co-occuring with the tissue MDA-MB-231-BAG cell in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset.

From TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025

proteins co-occuring with the tissue MDA-MB-231-Luc2 cell in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the CALHEX 231 drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the NVP 231 drug from theDGIdb Drug Targets 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC9691628-41598_2022_24642_MOESM1_ESM.pdf-231-ZNF652_ZNF652 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC4060771-170289.f1.pdf-231-SATB2_SATB2 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC10863267-12864_2024_10083_MOESM1_ESM.pdf-231-ZNF536_ZNF536 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.