Harmonizome 3.0

heat shock transcription factor 1

The product of this gene is a transcription factor that is rapidly induced after temperature stress and binds heat shock promoter elements (HSE). This protein plays a role in the regulation of lifespan. Expression of this gene is repressed by phosphorylation, which promotes binding by heat shock protein 90. [provided by RefSeq, Jul 2017]

From Reactome Pathways 2014

proteins participating in the HSF1-dependent transactivation pathway from the Reactome Pathways dataset.

From Reactome Pathways 2024

proteins participating in the HSF1-dependent transactivation pathway from the Reactome Pathways 2024 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC3916389-ppat.1003904.s008.xlsx-HSF1-regulated_genes-HSF1-Regulated_Genes_HSF1 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Biocarta Pathways

proteins participating in the role of egf receptor transactivation by gpcrs in cardiac hypertrophy pathway from the Biocarta Pathways dataset.

From CORUM Protein Complexes

proteins in the CD28-transactivation complex protein complex from the CORUM Protein Complexes dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term transactivation in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From GO Biological Process Annotations 2015

genes participating in the epidermal growth factor-activated receptor transactivation by g-protein coupled receptor signaling pathway biological process from the curated GO Biological Process Annotations 2015 dataset.

From GO Biological Process Annotations 2015

genes participating in the receptor transactivation biological process from the curated GO Biological Process Annotations 2015 dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the HIF-1 alpha, transactivation domain, C-terminal protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Sox C-terminal transactivation domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the p53 transactivation domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From Phosphosite Textmining Biological Term Annotations

proteins co-occuring with the biological term transactivation in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.

From Reactome Pathways 2014

proteins participating in the EGFR Transactivation by Gastrin pathway from the Reactome Pathways dataset.

From GO Biological Process Annotations 2023

genes participating in the receptor transactivation biological process from the curated GO Biological Process Annotations 2023 dataset.

From Reactome Pathways 2024

proteins participating in the EGFR Transactivation by Gastrin pathway from the Reactome Pathways 2024 dataset.

From GO Biological Process Annotations 2025

genes participating in the receptor transactivation biological process from the curated GO Biological Process Annotations 2025 dataset.

From ChEA Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the HSF1-23293686-STHDH_STRIATAL-MOUSE transcription factor binding site profile from the CHEA Transcription Factor Binding Site Profiles dataset.

From ChEA Transcription Factor Targets

target genes of the HSF1 transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.

From CORUM Protein Complexes

proteins in the HSF1-YWHAE complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the HSF1-HSF2 complex protein complex from the CORUM Protein Complexes dataset.

From ENCODE Transcription Factor Targets

target genes of the HSF1 transcription factor in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term hsf1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From MotifMap Predicted Transcription Factor Targets

target genes of the HSF1 transcription factor predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for HSF1 from the Pathway Commons Protein-Protein Interactions dataset.

From Reactome Pathways 2014

proteins participating in the Regulation of HSF1-mediated heat shock response pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the HSF1 activation pathway from the Reactome Pathways dataset.

From ChEA Transcription Factor Targets 2022

target genes of the HSF1-23293686-STHDH-STRIATAL-MOUSE transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.

From Reactome Pathways 2024

proteins participating in the HSF1 activation pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Regulation of HSF1-mediated heat shock response pathway from the Reactome Pathways 2024 dataset.

From JASPAR Predicted Human Transcription Factor Targets 2025

target genes of the HSF1 transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC3916389-ppat.1003904.s009.xlsx-Sheet1-HSF1-Regulated_Genes_Upregulated_during_VACV_infection_-_Filone_et_al_HSF1 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC5740759-40246_2017_131_MOESM1_ESM.xlsx-Table_S2-HSF1_CanSig_Genes-HSF1-CanSig_HSF1 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC5740759-40246_2017_131_MOESM1_ESM.xlsx-Table_S7-HSF1-Neigbhors-HSF1_Neighbors_hg38_HSF1 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From Rummagene Transcription Factor Associations 2026

target genes of the PMC10652340-ACEL-22-e13915-s007.xlsx-HSF1-SYMBOL_HSF1 transcription factor from the Rummagene Transcription Factor Associations 2026 dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the HSF1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.