Harmonizome 3.0

insulin-like growth factor 1 receptor

This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term igf1r in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Hub Proteins Protein-Protein Interactions

interacting proteins for hub protein IGF1R from the curated Hub Proteins Protein-Protein Interactions dataset.

From KEA Substrates of Kinases

substrates of the kinase IGF1R from the curated KEA Substrates of Kinases dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for IGF1R from the Pathway Commons Protein-Protein Interactions dataset.

From PhosphoSitePlus Substrates of Kinases

substrates of the kinase IGF1R from the curated PhosphoSitePlus Substrates of Kinases dataset.

From Kinase Library Tyrosine Kinome Atlas

substrates of the kinase IGF1R from the Kinase Library Tyrosine Kinome Atlas dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the IGF1R gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From COMPARTMENTS Curated Protein Localization Evidence Scores

proteins localized to the alphav-beta3 integrin-igf-1-igf1r complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

From GO Cellular Component Annotations 2015

proteins localized to the alphav-beta3 integrin-igf-1-igf1r complex cellular component from the curated GO Cellular Component Annotations 2015 dataset.

From Reactome Pathways 2014

proteins participating in the SHC-related events triggered by IGF1R pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the IRS-related events triggered by IGF1R pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the IGF1R signaling cascade pathway from the Reactome Pathways dataset.

From Reactome Pathways 2014

proteins participating in the Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway from the Reactome Pathways dataset.

From GO Cellular Component Annotations 2023

proteins localized to the alphav-beta3 integrin-IGF-1-IGF1R complex cellular component from the curated GO Cellular Component Annotations 2023 dataset.

From ChEA Transcription Factor Targets 2022

target genes of the IGF1R-20145208-DFB-HUMAN transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.

From Reactome Pathways 2024

proteins participating in the IGF1R signaling cascade pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the IRS-related events triggered by IGF1R pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the SHC-related events triggered by IGF1R pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway from the Reactome Pathways 2024 dataset.

From GO Cellular Component Annotations 2025

proteins localized to the alphav-beta3 integrin-IGF-1-IGF1R complex cellular component from the curated GO Cellular Component Annotations 2025 dataset.

From COMPARTMENTS Curated Protein Localization Evidence Scores 2025

proteins localized to the alphav-beta3 integrin-IGF-1-IGF1R complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.

From COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025

proteins co-occuring with the alphav-beta3 integrin-IGF-1-IGF1R complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.