Harmonizome 3.0

interleukin-1 receptor-associated kinase 4

This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term irak4 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From KEA Substrates of Kinases

substrates of the kinase IRAK4 from the curated KEA Substrates of Kinases dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for IRAK4 from the Pathway Commons Protein-Protein Interactions dataset.

From PhosphoSitePlus Substrates of Kinases

substrates of the kinase IRAK4 from the curated PhosphoSitePlus Substrates of Kinases dataset.

From Kinase Library Serine Threonine Kinome Atlas

substrates of the kinase IRAK4 from the Kinase Library Serine Threonine Kinome Atlas dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the IRAK4 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the IRAK4 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From ClinVar Gene-Phenotype Associations

genes associated with the IRAK4 deficiency phenotype from the curated ClinVar Gene-Phenotype Associations dataset.

From CTD Gene-Disease Associations

genes/proteins associated with the disease IRAK4 Deficiency from the curated CTD Gene-Disease Associations dataset.

From OMIM Gene-Disease Associations

genes associated with the irak4 deficiency phenotype from the curated OMIM Gene-Disease Associations dataset.

From DisGeNET Gene-Disease Associations

genes associated with the disease Irak4 Deficiency in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

From Reactome Pathways 2024

proteins participating in the IRAK4 deficiency (TLR2/4) pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the IRAK4 deficiency (TLR5) pathway from the Reactome Pathways 2024 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the IRAK4 INHIBITOR 4B [PMID: 18474425] drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the IRAK4 INHIBITOR RAC-45 [PMID: 18501603] drug from theDGIdb Drug Targets 2026 dataset.