Harmonizome 3.0

PCI domain containing 2

This gene encodes a component of the TREX-2 complex (transcription and export complex 2), which regulates mRNA export from the nucleus. This protein regulates expression of Mad2 mitotic arrest deficient-like 1, a cell division checkpoint protein. This protein also interacts with and stabilizes Brca2 (breast cancer 2) protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

From LINCS L1000 CMAP Chemical Perturbation Consensus Signatures

genes differentially expressed following the PCI-24781 small molecule perturbation from the LINCS L1000 CMAP Chemical Perturbation Consensus Signatures dataset.

From CORUM Protein Complexes

proteins in the PCI-PSA-SCG2 complex protein complex from the CORUM Protein Complexes dataset.

From COSMIC Cell Line Gene CNV Profiles

genes with high or low copy number in PCI-6A relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.

From COSMIC Cell Line Gene CNV Profiles

genes with high or low copy number in PCI-15A relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.

From COSMIC Cell Line Gene CNV Profiles

genes with high or low copy number in PCI-30 relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.

From COSMIC Cell Line Gene CNV Profiles

genes with high or low copy number in PCI-4B relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.

From COSMIC Cell Line Gene CNV Profiles

genes with high or low copy number in PCI-38 relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.

From COSMIC Cell Line Gene Mutation Profiles

genes mutated in the PCI-6A cell line from the COSMIC Cell Line Gene Mutation Profiles dataset.

From COSMIC Cell Line Gene Mutation Profiles

genes mutated in the PCI-15A cell line from the COSMIC Cell Line Gene Mutation Profiles dataset.

From COSMIC Cell Line Gene Mutation Profiles

genes mutated in the PCI-4B cell line from the COSMIC Cell Line Gene Mutation Profiles dataset.

From COSMIC Cell Line Gene Mutation Profiles

genes mutated in the PCI-38 cell line from the COSMIC Cell Line Gene Mutation Profiles dataset.

From COSMIC Cell Line Gene Mutation Profiles

genes mutated in the PCI-30 cell line from the COSMIC Cell Line Gene Mutation Profiles dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical PCI 32765 from the curated CTD Gene-Chemical Interactions dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term pci in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the PCI/PINT associated module protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Proteasome component (PCI) domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From Sanger Dependency Map Cancer Cell Line Proteomics

proteins associated with the cell line PCI-15A from the Sanger Dependency Map Cancer Cell Line Proteomics dataset.

From Sanger Dependency Map Cancer Cell Line Proteomics

proteins associated with the cell line PCI-30 from the Sanger Dependency Map Cancer Cell Line Proteomics dataset.

From Sanger Dependency Map Cancer Cell Line Proteomics

proteins associated with the cell line PCI-4B from the Sanger Dependency Map Cancer Cell Line Proteomics dataset.

From Sanger Dependency Map Cancer Cell Line Proteomics

proteins associated with the cell line PCI-6A from the Sanger Dependency Map Cancer Cell Line Proteomics dataset.

From DeepCoverMOA Drug Mechanisms of Action

proteins with high or low expression in PCI-34051 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

From TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025

proteins co-occuring with the tissue PCI-35 cell in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset.

From TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025

proteins co-occuring with the tissue PCI-43 cell in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the PCI-27483 drug from theDGIdb Drug Targets 2026 dataset.