Harmonizome 3.0

retinoblastoma 1

The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008]

RB1 divergent transcript

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term rb1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Hub Proteins Protein-Protein Interactions

interacting proteins for hub protein RB1 from the curated Hub Proteins Protein-Protein Interactions dataset.

From NURSA Protein-Protein Interactions

interacting proteins for RB1 from the NURSA Protein-Protein Interactions dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for RB1 from the Pathway Commons Protein-Protein Interactions dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the RB1 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the RB1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From CORUM Protein Complexes

proteins in the RB1-TFAP2A complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the RB1(hypophosphorylated)-E2F4 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the RB1-HDAC1-BRG1 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the Rb1-Runx2 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the CEBPE-E2F1-RB1 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the DNMT1-RB1-HDAC1-E2F1 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the TRIM27-RB1 complex protein complex from the CORUM Protein Complexes dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical ginsenoside Rb1 from the curated CTD Gene-Chemical Interactions dataset.

From NURSA Protein Complexes

proteins in the SC-50 (RB1) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From Reactome Pathways 2014

proteins participating in the Inhibition of replication initiation of damaged DNA by RB1/E2F1 pathway from the Reactome Pathways dataset.

From TISSUES Text-mining Tissue Protein Expression Evidence Scores

proteins co-occuring with the tissue snuot-rb1 cell in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.

From PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations

genes differentially expressed following the Perturb_11863_KO|KD|OE_Trp53/Rb1/Meis2|Kmt2c|Myc_SRP292755 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

From PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations

genes differentially expressed following the Perturb_11864_KO|KD|OE_Trp53/Rb1|Kmt2c|Myc_SRP292755 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

From PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations

genes differentially expressed following the Perturb_11865_KO|OE_Trp53/Rb1|Myc_SRP292755 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

From Reactome Pathways 2024

proteins participating in the Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Aberrant regulation of mitotic cell cycle due to RB1 defects pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Aberrant regulation of mitotic exit in cancer due to RB1 defects pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Defective translocation of RB1 mutants to the nucleus pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Inhibition of replication initiation of damaged DNA by RB1/E2F1 pathway from the Reactome Pathways 2024 dataset.

From TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025

proteins co-occuring with the tissue SNUOT-Rb1 cell in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset.