Harmonizome 3.0

sirtuin 1

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term sirt1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for SIRT1 from the Pathway Commons Protein-Protein Interactions dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the SIRT1 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the SIRT1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From CORUM Protein Complexes

proteins in the SIRT1-HNF4-alpha-PGC-1-alpha complex, in response to fasting protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the FOXO1-FHL2-SIRT1 complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the SIRT1 homotrimer complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the FOXO3-SIRT1 complex, oxidative stress stimulated protein complex from the CORUM Protein Complexes dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Active regulator of SIRT1 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From NURSA Protein Complexes

proteins in the BL3200 (SIRT1) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From NURSA Protein Complexes

proteins in the BL3203 (SIRT1) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From Reactome Pathways 2014

proteins participating in the SIRT1 negatively regulates rRNA Expression pathway from the Reactome Pathways dataset.

From PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations

genes differentially expressed following the Perturb_16813_OE_HNF1A/FOXA3/PROX1/SIRT1/PGC1A/AMPK_SRP167105 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

From PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations

genes differentially expressed following the Perturb_16814_OE_HNF1A/FOXA3/PROX1/SIRT1/PGC1A/AMPK_SRP167105 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

From PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations

genes differentially expressed following the Perturb_16815_OE_HNF1A/FOXA3/PROX1/SIRT1/PGC1A/AMPK_SRP167105 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

From Reactome Pathways 2024

proteins participating in the SIRT1 negatively regulates rRNA expression pathway from the Reactome Pathways 2024 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the SIRT1 ACTIVATOR 3 drug from theDGIdb Drug Targets 2026 dataset.