Harmonizome 3.0

TANK-binding kinase 1

The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. The protein is also an important kinase for antiviral innate immunity response. [provided by RefSeq, Sep 2021]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term tbk1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From KEA Substrates of Kinases

substrates of the kinase TBK1 from the curated KEA Substrates of Kinases dataset.

From NURSA Protein-Protein Interactions

interacting proteins for TBK1 from the NURSA Protein-Protein Interactions dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for TBK1 from the Pathway Commons Protein-Protein Interactions dataset.

From PhosphoSitePlus Substrates of Kinases

substrates of the kinase TBK1 from the curated PhosphoSitePlus Substrates of Kinases dataset.

From Kinase Library Serine Threonine Kinome Atlas

substrates of the kinase TBK1 from the Kinase Library Serine Threonine Kinome Atlas dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the TBK1 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the TBK1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Tbk1/Ikki binding domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations

genes differentially expressed following the TBK1.DF gene perturbation from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.

From MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations

genes differentially expressed following the TBK1.DN.48HRS gene perturbation from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.

From NURSA Protein Complexes

proteins in the BL703 (TBK1) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From NURSA Protein Complexes

proteins in the BL702 (TBK1) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From NURSA Protein Complexes

proteins in the BL701 (TBK1) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From Reactome Pathways 2014

proteins participating in the Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon pathway from the Reactome Pathways dataset.

From Reactome Pathways 2024

proteins participating in the Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation pathway from the Reactome Pathways 2024 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the TBK1 PROTAC 3I drug from theDGIdb Drug Targets 2026 dataset.