Harmonizome 3.0

KDEL (Lys-Asp-Glu-Leu) containing 1 pseudogene 1

transfer RNA-Leu (AAG) 4-1

transfer RNA-Leu (TAG) 1-1

nuclear-encoded mitochondrial transfer RNA-Leu (TAA) 1-1

transfer RNA-Leu (AAG) 5-1

transfer RNA-Leu (CAG) 1-6

transfer RNA-Leu (CAG) 1-7

transfer RNA-Leu (CAG) 1-4

transfer RNA-Leu (CAG) 1-5

transfer RNA-Leu (CAG) 1-2

transfer RNA-Leu (CAG) 1-3

transfer RNA-Leu (CAG) 1-1

transfer RNA-Leu (TAA) 1-1

transfer RNA-Leu (CAA) 6-1

transfer RNA-Leu (TAA) 4-1

transfer RNA-Leu (CAA) 7-1

transfer RNA-Leu (TAG) 4-1

nuclear-encoded mitochondrial transfer RNA-Leu (TAA) 4-1

nuclear-encoded mitochondrial transfer RNA-Leu (TAA) 5-1

transfer RNA-Leu (AAG) 2-3

transfer RNA-Leu (AAG) 2-2

transfer RNA-Leu (AAG) 2-1

transfer RNA-Leu (AAG) 2-4

transfer RNA-Leu (AAG) 6-1

transfer RNA-Leu (CAA) 1-1

transfer RNA-Leu (CAA) 1-2

transfer RNA-Leu (CAA) 3-1

KDEL (Lys-Asp-Glu-Leu) containing 1

This gene encodes a protein product localized to the lumen of the endoplasmic reticulum. As a member of the endoplasmic reticulum protein family the encoded protein contains a Lys-Asp-Glu-Leu or KDEL motif located at the extreme C-terminus which prevents all endoplasmic reticulum resident proteins from being secreted. Proteins carrying this motif are bound by a receptor in the Golgi apparatus so that the receptor-ligand complex returns to the endoplasmic reticulum. A processed non-transcribed pseudogene located in an intron of a sodium transporter gene on chromosome 5 has been defined for this gene. This gene has multiple transcript variants which are predicted to encode distinct isoforms. [provided by RefSeq, Jan 2016]

KDEL (Lys-Asp-Glu-Leu) containing 2

Enables UDP-glucosyltransferase activity and UDP-xylosyltransferase activity. Involved in protein O-linked glycosylation via serine. Predicted to be located in endoplasmic reticulum lumen. Predicted to be active in endomembrane system. [provided by Alliance of Genome Resources, Mar 2025]

transfer RNA-Leu (CAA) 4-1

transfer RNA-Leu (TAG) 3-1

transfer RNA-Leu (AAG) 3-1

transfer RNA-Leu (CAA) 5-1

transfer RNA-Leu (CAG) 2-1

transfer RNA-Leu (CAG) 2-2

nuclear-encoded mitochondrial transfer RNA-Leu (TAA) 3-1

transfer RNA-Leu (TAG) 2-1

transfer RNA-Leu (CAG) 3-1

nuclear-encoded mitochondrial transfer RNA-Leu (TAA) 6-1

transfer RNA-Leu (TAA) 3-1

transfer RNA-Leu (AAG) 7-1

transfer RNA-Leu (AAG) 8-1

transfer RNA-Leu (TAA) 2-1

nuclear-encoded mitochondrial transfer RNA-Leu (TAA) 2-1

KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2

Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR2 was the second member of the family to be identified, and it encodes a protein which is 83% identical to the KDELR1 gene product. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3

This gene encodes a member of the KDEL endoplasmic reticulum protein retention receptor family. Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR3 was the third member of the family to be identified. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1

Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, which is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. The protein encoded by this gene was the first member of the family to be identified, and it encodes a protein structurally and functionally similar to the yeast ERD2 gene product. [provided by RefSeq, Jul 2008]

transfer RNA-Leu (TAA) 5-1

transfer RNA-Leu (AAG) 1-1

transfer RNA-Leu (AAG) 1-2

transfer RNA-Leu (AAG) 1-3

transfer RNA-Leu (CAA) 2-1

From DGIdb Drug Targets 2026

interacting proteins for the [LEU]ENKEPHALIN drug from theDGIdb Drug Targets 2026 dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical enkephalin-Leu, Ala(2)-melphalan methyl ester- from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical enkephalin, Ser(2), Leu(5), Thr(6)- from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical enkephalin-Leu, Ala(2)-Arg(6)- from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical Leu-Ser-Lys-Leu peptide from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical bombesin (6-14), Tpi(6)-Leu(13)-psi(CH2NH)-Leu(14)- from the curated CTD Gene-Chemical Interactions dataset.

From DrugBank Drug Targets

interacting proteins for the CBZ-LEU-LEU-TYR-CH2F drug from the curated DrugBank Drug Targets dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the Met-Met-Trp-Leu-Leu ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the [D-Tpi⁶ Leu¹³ ψ(CH₂NH)-Leu¹⁴]bombesin-(6-14) ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the fMet-Met-Trp-Leu-Leu ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From DGIdb Drug Targets 2026

interacting proteins for the FMET-MET-TRP-LEU-LEU drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the MET-MET-TRP-LEU-LEU drug from theDGIdb Drug Targets 2026 dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical Enkephalin, Ala(2)-MePhe(4)-Gly(5)- from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical Enkephalin, Leucine from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical Enkephalin, Leucine-2-Alanine from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical Enkephalin, D-Penicillamine (2,5)- from the curated CTD Gene-Chemical Interactions dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term enkephalin in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From GO Biological Process Annotations 2015

genes participating in the enkephalin processing biological process from the curated GO Biological Process Annotations 2015 dataset.

From GO Molecular Function Annotations 2015

genes performing the enkephalin receptor activity molecular function from the curated GO Molecular Function Annotations 2015 dataset.

From PANTHER Pathways

proteins participating in the Enkephalin release pathway from the PANTHER Pathways dataset.

From GO Biological Process Annotations 2023

genes participating in the enkephalin processing biological process from the curated GO Biological Process Annotations 2023 dataset.

From GO Molecular Function Annotations 2023

genes performing the G protein-coupled enkephalin receptor activity molecular function from the curated GO Molecular Function Annotations 2023 dataset.

From GO Biological Process Annotations 2025

genes participating in the enkephalin processing biological process from the curated GO Biological Process Annotations 2025 dataset.

From GO Molecular Function Annotations 2025

genes performing the G protein-coupled enkephalin receptor activity molecular function from the curated GO Molecular Function Annotations 2025 dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical LHRH, Leu(6)-des-Et-GlyNH2(10)- from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical bradykinin, Lys-Leu(8)-desArg(9)- from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical Phe-Leu boronic acid from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical neuropeptide Y, Leu(31)-Pro(34)- from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical vasoactive intestinal peptide, 4-chloro-Phe(6)-Leu(17)- from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical bradykinin, Leu(8)-des-Arg(9)- from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical cyclo(Trp-Asp-Pro-Val-Leu) from the curated CTD Gene-Chemical Interactions dataset.

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical cyclo(Gln-Trp-Phe-Gly-Leu-Met) from the curated CTD Gene-Chemical Interactions dataset.

From GAD Gene-Disease Associations

genes associated with the disease apolipoprotein e mutation [apolipoprotein e (delta149 leu)] in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term leu in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the fMet-Ile-Val-Ile-Leu ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the fMet-Leu-Phe-Glu ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the [Leu⁹ des-Arg¹⁰]kallidin ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the des-His¹-[Leu⁴-Glu⁹]glucagon-NH₂ ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the fMet-Leu-Phe ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the [Leu¹⁴ ψ 13-14)]bombesin ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the d[Leu⁴]AVP ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the [D-Arg¹ D-Trp^{7 9} Leu¹¹]substance P ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the [Leu³¹ Pro³⁴]NPY ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the [Leu³¹ Pro³⁴]NPY (pig) ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the [Leu³¹ Pro³⁴]PYY (pig) ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the [¹⁹Lys ²⁶Leu]-galparan ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the [Leu³¹ Pro³⁴]PYY (human) ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the fMet-Met-Tyr-Ala-Leu-Phe ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the [Lys¹⁵ Arg¹⁶ Leu²⁷]VIP-(1–7)/GRF-(8–27)-NH₂ ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the [Leu¹³]motilin (human) ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the [Leu⁸ des-Arg⁹]bradykinin ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the [Leu⁸]-phyllolitorin ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the [¹²⁵I][Leu³¹ Pro³⁴]NPY ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the i-Boc-Met-Leu-Phe ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the t-Boc-Met-Leu-Phe ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the fMet-Ile-Val-Thr-Leu-Phe ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the d[Leu⁴]LVP ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the [Phe³ Leu¹³]motilin (human) ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the [Lys⁵ Me-Leu⁹ Nle¹⁰]NKA-(4-10) ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the d[Leu⁴ Dap⁸]VP ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the fMet-Leu-Phe-Ile-Ile-Lys-FITC ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the Z-Arg-Leu-Val-Agly-Ile-Val-OMe ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the [D-Arg¹ D-Phe⁵ D-Trp^{7 9} Leu¹¹]substance P ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the [Ala¹¹ D-Leu¹⁵]orexin-B ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the Ac-Lys-[MeAla⁶ Leu⁸ des-Arg⁹]bradykinin ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the fMet-Ile-Phe-Leu ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the [Ac-D-2Nal¹ D4CPA² D-3Pal^{3 6} Leu⁸ D-Ala¹⁰]GnRH-II ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the [³H]Lys-[Leu⁸][des-Arg⁹]BK ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the [³H]fMet-Leu-Phe ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

From DeepCoverMOA Drug Mechanisms of Action

proteins with high or low expression in HMB-Val-Ser-Leu-VE relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

From DGIdb Drug Targets 2026

interacting proteins for the Z-ARG-LEU-VAL-AGLY-ILE-VAL-OME drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the FMET-ILE-PHE-LEU drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the FMET-ILE-VAL-ILE-LEU drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the FMET-ILE-VAL-THR-LEU-PHE drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the FMET-LEU-PHE drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the FMET-LEU-PHE-ILE-ILE drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the FMET-MET-TYR-ALA-LEU-PHE drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the I-BOC-MET-LEU-PHE drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the T-BOC-MET-LEU-PHE drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the [3H]FMET-LEU-PHE drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the [3H]LEU-N/OFQ drug from theDGIdb Drug Targets 2026 dataset.

From DGIdb Drug Targets 2026

interacting proteins for the MULTI-LEU (ML)-PEPTIDE drug from theDGIdb Drug Targets 2026 dataset.