Harmonizome 3.0

BCL2-associated agonist of cell death

The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL (B-cell lymphoma-extra large) and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform. [provided by RefSeq, Dec 2019]

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term bad in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for BAD from the Pathway Commons Protein-Protein Interactions dataset.

From Phosphosite Textmining Biological Term Annotations

proteins co-occuring with the biological term bad in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the BAD gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the BAD gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

From Biocarta Pathways

proteins participating in the regulation of bad phosphorylation pathway from the Biocarta Pathways dataset.

From Biocarta Pathways

proteins participating in the multiple antiapoptotic pathways from igf-1r signaling lead to bad phosphorylation pathway from the Biocarta Pathways dataset.

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the bad-bcl-xl complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the bad-bcl-2 complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

From CORUM Protein Complexes

proteins in the Bad-Gk-Wave1-Pkaca-Ppp1cc complex protein complex from the CORUM Protein Complexes dataset.

From CORUM Protein Complexes

proteins in the BAD-BCL2xL complex protein complex from the CORUM Protein Complexes dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Pro-apoptotic Bcl-2 protein, BAD protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From Reactome Pathways 2014

proteins participating in the Activation of BAD and translocation to mitochondria pathway from the Reactome Pathways dataset.

From DisGeNET Gene-Phenotype Associations

genes associated with the phenotype Prognosis Bad in GWAS and other genetic association datasets from the DisGeNET Gene-Phenotype Associations dataset.

From Reactome Pathways 2024

proteins participating in the Activation of BAD and translocation to mitochondria pathway from the Reactome Pathways 2024 dataset.

From COMPARTMENTS Curated Protein Localization Evidence Scores 2025

proteins localized to the BAD-BCL-2 complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.

From COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025

proteins co-occuring with the BAD-BCL-xl complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.

From COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025

proteins co-occuring with the BAD-BCL-2 complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.