Harmonizome 3.0

phosphatase and tensin homolog

This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of this gene is found on chromosome 9. Alternative splicing and the use of multiple translation start codons results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015]

PTEN induced putative kinase 1

This gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease. [provided by RefSeq, Jul 2008]

TPTE and PTEN homologous inositol lipid phosphatase pseudogene

From NURSA Protein Complexes

proteins in the BL2789 (PTEN) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From NURSA Protein Complexes

proteins in the a-PTEN (WG) (PTEN) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From Biocarta Pathways

proteins participating in the pten dependent cell cycle arrest and apoptosis pathway from the Biocarta Pathways dataset.

From ClinVar Gene-Phenotype Associations

genes associated with the PTEN hamartoma tumor syndrome phenotype from the curated ClinVar Gene-Phenotype Associations dataset.

From DEPOD Substrates of Phosphatases

substrates of the phosphatase PTEN from the curated DEPOD Substrates of Phosphatases dataset.

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term pten in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Bifunctional phosphatidylinositol trisphosphate phosphatase/dual specificity phosphatase PTEN protein domain from the InterPro Predicted Protein Domain Annotations dataset.

From MSigDB Cancer Gene Co-expression Modules

co-expressed genes for PTEN from the MSigDB Cancer Gene Co-expression Modules dataset.

From NURSA Protein Complexes

proteins in the BL798 (PTEN) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From NURSA Protein Complexes

proteins in the BL2790 (PTEN) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From NURSA Protein Complexes

proteins in the ABM-2052 (6H2.1) (PTEN) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From NURSA Protein Complexes

proteins in the BL2791 (PTEN) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From NURSA Protein Complexes

proteins in the BL2788 (PTEN) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

From NURSA Protein-Protein Interactions

interacting proteins for PTEN from the NURSA Protein-Protein Interactions dataset.

From OMIM Gene-Disease Associations

genes associated with the pten hamartoma tumor syndrome phenotype from the curated OMIM Gene-Disease Associations dataset.

From Pathway Commons Protein-Protein Interactions

interacting proteins for PTEN from the Pathway Commons Protein-Protein Interactions dataset.

From Phosphosite Textmining Biological Term Annotations

proteins co-occuring with the biological term pten in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.

From DisGeNET Gene-Disease Associations

genes associated with the disease Pten Hamartoma Tumor Syndrome in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

From DisGeNET Gene-Disease Associations

genes associated with the disease Pten Hamartoma Tumor Syndrome With Granular Cell Tumor in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

From LINCS L1000 CMAP CRISPR Knockout Consensus Signatures

genes differentially expressed following the PTEN gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

From PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations

genes differentially expressed following the Perturb_14127_KO_TP53/CDKN2A/PTEN/NF1_SRP258861 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

From PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations

genes differentially expressed following the Perturb_13825_KO|OE_Nf1/Pten/Efgr_SRP302970 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

From PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations

genes differentially expressed following the Perturb_6527_KO_Trp53/Nf1/Pten/Pot1a/Pot1b_SRP293265 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

From PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations

genes differentially expressed following the Perturb_6528_KO_Trp53/Nf1/Pten/Pot1a/Pot1b_SRP293265 gene perturbation from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

From Reactome Pathways 2024

proteins participating in the Competing endogenous RNAs (ceRNAs) regulate PTEN translation pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the PTEN Loss of Function in Cancer pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the PTEN Regulation pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Regulation of PTEN gene transcription pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Regulation of PTEN localization pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Regulation of PTEN mRNA translation pathway from the Reactome Pathways 2024 dataset.

From Reactome Pathways 2024

proteins participating in the Regulation of PTEN stability and activity pathway from the Reactome Pathways 2024 dataset.

From DISEASES Curated Gene-Disease Association Evidence Scores 2025

genes involed in the disease PTEN hamartoma tumor syndrome from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.

From DISEASES Text-mining Gene-Disease Association Evidence Scores 2025

genes co-occuring with the disease PTEN hamartoma tumor syndrome in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

From COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025

proteins co-occuring with the PTEN phosphatase complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.

From ClinVar Gene-Phenotype Associations 2025

genes associated with the PTEN hamartoma tumor syndrome phenotype from the curated ClinVar Gene-Phenotype Associations 2025 dataset.

From ClinVar Gene-Phenotype Associations 2025

genes associated with the PTEN hamartoma tumor syndromes phenotype from the curated ClinVar Gene-Phenotype Associations 2025 dataset.

From CM4AI KOLF21J CRISPRi Gene Perturbation Atlas

genes differentially expressed following the PTEN gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.